Recording Activity-Dependent Release of BDNF from Hippocampal Neurons

2018 ◽  
pp. 119-129 ◽  
Author(s):  
Tanja Brigadski ◽  
Petra Lichtenecker ◽  
Volkmar Lessmann
Keyword(s):  
Hippocampal Neurons ◽  
Activity Dependent

scholarly journals Regulation of intrinsic excitability in hippocampal neurons by activity-dependent modulation of the KV2.1 potassium channel

Channels ◽  
2009 ◽  
Vol 3 (1) ◽  
pp. 46-56 ◽  
Author(s):  
Durga P. Mohapatra ◽  
Hiroaki Misonou ◽  
Pan Sheng-Jun ◽  
Joshua E. Held ◽  
D. James Surmeier ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Hippocampal Neurons ◽  
Intrinsic Excitability ◽  
Activity Dependent

Activity-dependent release of tissue plasminogen activator from the dendritic spines of hippocampal neurons revealed by live-cell imaging

2006 ◽  
Vol 66 (6) ◽  
pp. 564-577 ◽  
Author(s):  
Janis E. Lochner ◽  
Leah S. Honigman ◽  
Wilmon F. Grant ◽  
Sarah K. Gessford ◽  
Alexis B. Hansen ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Dendritic Spines ◽  
Hippocampal Neurons ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Live Cell ◽  
Tissue Plasminogen ◽  
Activity Dependent

scholarly journals Activity-Dependent Facilitation of CaV1.3 Calcium Channels Promotes KCa3.1 Activation in Hippocampal Neurons

2017 ◽  
Vol 37 (46) ◽  
pp. 11255-11270 ◽  
Author(s):  
Giriraj Sahu ◽  
Hadhimulya Asmara ◽  
Fang-Xiong Zhang ◽  
Gerald W. Zamponi ◽  
Ray W. Turner
Keyword(s):  
Calcium Channels ◽  
Hippocampal Neurons ◽  
Activity Dependent

scholarly journals Iron handling in hippocampal neurons: activity-dependent iron entry and mitochondria-mediated neurotoxicity

Aging Cell ◽  
2011 ◽  
Vol 10 (1) ◽  
pp. 172-183 ◽  
Author(s):  
Ilaria Pelizzoni ◽  
Romina Macco ◽  
Marco Francesco Morini ◽  
Daniele Zacchetti ◽  
Fabio Grohovaz ◽  
...  
Keyword(s):  
Hippocampal Neurons ◽  
Activity Dependent

scholarly journals Systematic identification of 3′-UTR regulatory elements in activity-dependent mRNA stability in hippocampal neurons

2014 ◽  
Vol 369 (1652) ◽  
pp. 20130509 ◽  
Author(s):  
Jonathan E. Cohen ◽  
Philip R. Lee ◽  
R. Douglas Fields
Keyword(s):  
Neuronal Activity ◽  
Mrna Stability ◽  
Hippocampal Neurons ◽  
Transcriptional Control ◽  
Regulatory Elements ◽  
Memory Storage ◽  
Long Term Memory ◽  
Synaptic Connections ◽  
Activity Dependent

Ongoing neuronal activity during development and plasticity acts to refine synaptic connections and contributes to the induction of plasticity and ultimately long-term memory storage. Activity-dependent, post-transcriptional control of mRNAs occurs through transport to axonal and dendritic compartments, local translation and mRNA stability. We have identified a mechanism that contributes to activity-dependent regulation of mRNA stability during synaptic plasticity in rat hippocampal neurons. In this study, we demonstrate rapid, post-transcriptional control over process-enriched mRNAs by neuronal activity. Systematic analysis of the 3′-UTRs of destabilized transcripts, identifies enrichment in sequence motifs corresponding to microRNA (miRNA)-binding sites. The miRNAs that were identified, miR-326-3p/miR-330-5p, miR-485-5p, miR-666-3p and miR-761 are predicted to regulate networks of genes important in plasticity and development. We find that these miRNAs are developmentally regulated in the hippocampus, many increasing by postnatal day 14. We further find that miR-485-5p controls NGF-induced neurite outgrowth in PC12 cells, tau expression and axonal development in hippocampal neurons. miRNAs can function at the synapse to rapidly control and affect short- and long-term changes at the synapse. These processes likely occur during refinement of synaptic connections and contribute to the induction of plasticity and learning and memory.

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