scholarly journals Regulation of intrinsic excitability in hippocampal neurons by activity-dependent modulation of the KV2.1 potassium channel

Channels ◽  
2009 ◽  
Vol 3 (1) ◽  
pp. 46-56 ◽  
Author(s):  
Durga P. Mohapatra ◽  
Hiroaki Misonou ◽  
Pan Sheng-Jun ◽  
Joshua E. Held ◽  
D. James Surmeier ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Hippocampal Neurons ◽  
Intrinsic Excitability ◽  
Activity Dependent

scholarly journals Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs

2021 ◽  
Vol 17 (9) ◽  
pp. e1009378
Author(s):  
Adrienn Szabó ◽  
Katalin Schlett ◽  
Attila Szücs
Keyword(s):  
Hippocampal Neurons ◽  
Intrinsic Excitability ◽  
High Yield ◽  
Kinetic Properties ◽  
Dynamic Clamp ◽  
Synaptic Inputs ◽  
Proportional Relationship ◽  
Activity Dependent ◽  
K Currents ◽  
Synaptic Responses

Activity-dependent regulation of intrinsic excitability has been shown to greatly contribute to the overall plasticity of neuronal circuits. Such neuroadaptations are commonly investigated in patch clamp experiments using current step stimulation and the resulting input-output functions are analyzed to quantify alterations in intrinsic excitability. However, it is rarely addressed, how such changes translate to the function of neurons when they operate under natural synaptic inputs. Still, it is reasonable to expect that a strong correlation and near proportional relationship exist between static firing responses and those evoked by synaptic drive. We challenge this view by performing a high-yield electrophysiological analysis of cultured mouse hippocampal neurons using both standard protocols and simulated synaptic inputs via dynamic clamp. We find that under these conditions the neurons exhibit vastly different firing responses with surprisingly weak correlation between static and dynamic firing intensities. These contrasting responses are regulated by two intrinsic K-currents mediated by Kv1 and Kir channels, respectively. Pharmacological manipulation of the K-currents produces differential regulation of the firing output of neurons. Static firing responses are greatly increased in stuttering type neurons under blocking their Kv1 channels, while the synaptic responses of the same neurons are less affected. Pharmacological blocking of Kir-channels in delayed firing type neurons, on the other hand, exhibit the opposite effects. Our subsequent computational model simulations confirm the findings in the electrophysiological experiments and also show that adaptive changes in the kinetic properties of such currents can even produce paradoxical regulation of the firing output.

Activity-dependent release of tissue plasminogen activator from the dendritic spines of hippocampal neurons revealed by live-cell imaging

2006 ◽  
Vol 66 (6) ◽  
pp. 564-577 ◽  
Author(s):  
Janis E. Lochner ◽  
Leah S. Honigman ◽  
Wilmon F. Grant ◽  
Sarah K. Gessford ◽  
Alexis B. Hansen ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Dendritic Spines ◽  
Hippocampal Neurons ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Live Cell ◽  
Tissue Plasminogen ◽  
Activity Dependent

scholarly journals Protective actions of potassium channel openers on ischemia-induced amnesia and apoptosis of hippocampal neurons in mice

1997 ◽  
Vol 73 ◽  
pp. 270
Author(s):  
Kaoru Nakao ◽  
Shogo Tokuyama ◽  
Hisanori Kawashima ◽  
Masakatsu Takahashi ◽  
Hiroshi Ueda
Keyword(s):  
Potassium Channel ◽  
Hippocampal Neurons ◽  
Potassium Channel Openers ◽  
Protective Actions

scholarly journals Activity-Dependent Facilitation of CaV1.3 Calcium Channels Promotes KCa3.1 Activation in Hippocampal Neurons

2017 ◽  
Vol 37 (46) ◽  
pp. 11255-11270 ◽  
Author(s):  
Giriraj Sahu ◽  
Hadhimulya Asmara ◽  
Fang-Xiong Zhang ◽  
Gerald W. Zamponi ◽  
Ray W. Turner
Keyword(s):  
Calcium Channels ◽  
Hippocampal Neurons ◽  
Activity Dependent

scholarly journals Iron handling in hippocampal neurons: activity-dependent iron entry and mitochondria-mediated neurotoxicity

Aging Cell ◽  
2011 ◽  
Vol 10 (1) ◽  
pp. 172-183 ◽  
Author(s):  
Ilaria Pelizzoni ◽  
Romina Macco ◽  
Marco Francesco Morini ◽  
Daniele Zacchetti ◽  
Fabio Grohovaz ◽  
...  
Keyword(s):  
Hippocampal Neurons ◽  
Activity Dependent
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