Fabrication Protocol for Thermoplastic Microfluidic Devices: Nanoliter Volume Bioreactors for Cell Culturing

2021 ◽  
Author(s):  
Elif Gencturk ◽  
Senol Mutlu ◽  
Kutlu O. Ulgen
Keyword(s):  
Microfluidic Devices ◽  
Cell Culturing

Robust chemical bonding of PMMA microfluidic devices to porous PETE membranes for reliable cytotoxicity testing of drugs

Lab on a Chip ◽  
2019 ◽  
Vol 19 (21) ◽  
pp. 3706-3713 ◽  
Author(s):  
Thao Nguyen ◽  
Su Hyun Jung ◽  
Min Seok Lee ◽  
Tae-Eun Park ◽  
Suk-kyun Ahn ◽  
...  
Keyword(s):  
Chemical Bonding ◽  
Microfluidic Devices ◽  
Lipophilic Drugs ◽  
Cytotoxicity Testing ◽  
Cell Culturing

A GLYMO-based method enables robust fabrication of PMMA–PETE cell-culturing microfluidic devices, which permits more precise cytotoxicity response to lipophilic drugs.

Modelling neuroendocrine tumours using 3 dimensional cell culturing

2020 ◽  
Author(s):  
Lilla Krokker ◽  
Borbála Szabó ◽  
Kinga Németh ◽  
Balázs Sarkadi ◽  
Katalin Mészáros ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
3 Dimensional ◽  
Cell Culturing ◽  
Dimensional Cell

Review of Microfluidic Devices for On-Chip Chemical Sensing

2016 ◽  
Vol 136 (6) ◽  
pp. 244-249
Author(s):  
Takahiro Watanabe ◽  
Fumihiro Sassa ◽  
Yoshitaka Yoshizumi ◽  
Hiroaki Suzuki
Keyword(s):  
Chemical Sensing ◽  
Microfluidic Devices ◽  
On Chip

Production of O/W Emulsions Containing Astaxanthin by Microfluidic Devices

2020 ◽  
Vol 15 (1) ◽  
pp. 63-68
Author(s):  
Yu. V. Ulianova ◽  
A. M. Popov ◽  
N. P. Babichenko ◽  
K. V. Gorin ◽  
Ya. E. Sergeeva
Keyword(s):  
Microfluidic Devices

scholarly journals A Numerical Study of Sub-Millisecond Integrated Mix-and-Inject Microfluidic Devices for Sample Delivery at Synchrotron and XFELs

2021 ◽  
Vol 11 (8) ◽  
pp. 3404
Author(s):  
Majid Hejazian ◽  
Eugeniu Balaur ◽  
Brian Abbey
Keyword(s):  
Molecular Dynamics ◽  
Flow Rate ◽  
Numerical Study ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Liquid Jets ◽  
Mixing Efficiency ◽  
X Ray Diffraction ◽  
Cross Sectional ◽  
Time Required

Microfluidic devices which integrate both rapid mixing and liquid jetting for sample delivery are an emerging solution for studying molecular dynamics via X-ray diffraction. Here we use finite element modelling to investigate the efficiency and time-resolution achievable using microfluidic mixers within the parameter range required for producing stable liquid jets. Three-dimensional simulations, validated by experimental data, are used to determine the velocity and concentration distribution within these devices. The results show that by adopting a serpentine geometry, it is possible to induce chaotic mixing, which effectively reduces the time required to achieve a homogeneous mixture for sample delivery. Further, we investigate the effect of flow rate and the mixer microchannel size on the mixing efficiency and minimum time required for complete mixing of the two solutions whilst maintaining a stable jet. In general, we find that the smaller the cross-sectional area of the mixer microchannel, the shorter the time needed to achieve homogeneous mixing for a given flow rate. The results of these simulations will form the basis for optimised designs enabling the study of molecular dynamics occurring on millisecond timescales using integrated mix-and-inject microfluidic devices.

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