Multicompartmental Hollow-Fiber-Based Bioreactors for Dynamic Three-Dimensional Perfusion Culture

2016 ◽  
pp. 1-19 ◽  
Author(s):  
Eva Schmelzer ◽  
Jörg C. Gerlach
Keyword(s):  
Hollow Fiber ◽  
Three Dimensional ◽  
Perfusion Culture

Evaluation of the mass transfer rate using computer simulation in a three-dimensional interwoven hollow fiber-type bioartificial liver

2018 ◽  
Vol 40 (11-12) ◽  
pp. 1567-1578 ◽  
Author(s):  
Ryoichi Sakiyama ◽  
Hiroyuki Hamada ◽  
Brandon Blau ◽  
Nora Freyer ◽  
Katrin Zeilinger ◽  
...  
Keyword(s):  
Mass Transfer ◽  
Computer Simulation ◽  
Hollow Fiber ◽  
Transfer Rate ◽  
Fiber Type ◽  
Mass Transfer Rate ◽  
Three Dimensional ◽  
Bioartificial Liver

scholarly journals Computation of Global and Local Mass Transfer in Hollow Fiber Membrane Modules

2020 ◽  
Vol 12 (6) ◽  
pp. 2207
Author(s):  
Benjamin Lukitsch ◽  
Paul Ecker ◽  
Martin Elenkov ◽  
Christoph Janeczek ◽  
Bahram Haddadi ◽  
...  
Keyword(s):  
Mass Transfer ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Three Dimensional ◽  
Co2 Removal ◽  
Fiber Membrane ◽  
Separation Processes ◽  
Flexible Tool ◽  
Species Transport ◽  
Flow Simulations

Computational fluid dynamics (CFD) provides a flexible tool for investigation of separation processes within membrane hollow fiber modules. By enabling a three-dimensional and time dependent description of the corresponding transport phenomena, very detailed information about mass transfer or geometrical influences can be provided. The high level of detail comes with high computational costs, especially since species transport simulations must discretize and resolve steep gradients in the concentration polarization layer at the membrane. In contrast, flow simulations are not required to resolve these gradients. Hence, there is a large gap in the scale and complexity of computationally feasible geometries when comparing flow and species transport simulations. A method, which tries to cover the mentioned gap, is presented in the present article. It allows upscaling of the findings of species transport simulations, conducted for reduced geometries, on the geometrical scales of flow simulations. Consequently, total transmembrane transport of complete modules can be numerically predicted. The upscaling method does not require any empirical correlation to incorporate geometrical characteristics but solely depends on results acquired by CFD flow simulations. In the scope of this research, the proposed method is explained, conducted, and validated. This is done by the example of CO2 removal in a prototype hollow fiber membrane oxygenator.

Steady three-dimensional flows past hollow fiber membrane arrays – cross flow arrangement

2018 ◽  
Vol 96 (12) ◽  
pp. 1272-1287 ◽  
Author(s):  
Mustafa Usta ◽  
Michael Morabito ◽  
Mohammed Alrehili ◽  
Alaa Hakim ◽  
Alparslan Oztekin
Keyword(s):  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Flow Behavior ◽  
Membrane Surface ◽  
Three Dimensional ◽  
Cross Flow ◽  
Coefficient Of Performance ◽  
Fiber Membrane ◽  
Cfd Simulations ◽  
Flow Configuration

Hollow fiber membrane (HFM) modules are among the most common separation devices employed in membrane separation applications. Three-dimensional steady-state computational fluid dynamics (CFD) simulations are carried out to study flow past hollow fiber membrane banks (HFMB). The current study investigates the effects of flow behavior on membrane performance during binary mixture separations. Carbon dioxide (CO2) removal from methane (CH4) is examined for various arrangements of HFMs in staggered and inline configurations. The common HFM module arrangement is the axial flow configuration. However, this work focuses on the radial cross-flow configuration. The HFM surface is a functional boundary where the suction rate and concentration of each species are coupled and are functions of the local partial pressures, the permeability, and the selectivity of the HFM. CFD simulations employed the turbulent k–ω shear stress transport (SST) model to study HFM performance for Reynolds numbers, 200 ≤ Re ≤ 1000. The efficiency of the inline and staggered arrangements in the separation module is evaluated by the coefficient of performance and the rate of mass flow per unit area of CO2 passing across the membrane surface. This work demonstrates that the module with staggered arrangement outperforms the module with the inline arrangement.

High Cell-Density Culture System of Hepatocytes Entrapped in a Three-Dimensional Hollow Fiber Module with Collagen Gel

1995 ◽  
Vol 19 (2) ◽  
pp. 191-193 ◽  
Author(s):  
Kazuyoshi Takeshita ◽  
Haruaki Ishibashi ◽  
Masayuki Suzuki ◽  
Takumi Yamamoto ◽  
Toshihiro Akaike ◽  
...  
Keyword(s):  
Cell Density ◽  
Hollow Fiber ◽  
Culture System ◽  
High Cell Density ◽  
Three Dimensional ◽  
Collagen Gel ◽  
High Cell Density Culture ◽  
High Cell
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