The Blood–Brain Barrier: An Introduction to Its Structure and Function

2013 ◽  
pp. 1-20 ◽  
Author(s):  
Anne Mahringer ◽  
Melanie Ott ◽  
Gert Fricker
Keyword(s):  
Blood Brain Barrier ◽  
Structure And Function ◽  
Brain Barrier ◽  
Blood Brain ◽  
And Function

Structure and function of the blood–brain barrier

2010 ◽  
Vol 37 (1) ◽  
pp. 13-25 ◽  
Author(s):  
N. Joan Abbott ◽  
Adjanie A.K. Patabendige ◽  
Diana E.M. Dolman ◽  
Siti R. Yusof ◽  
David J. Begley
Keyword(s):  
Blood Brain Barrier ◽  
Structure And Function ◽  
Brain Barrier ◽  
Blood Brain ◽  
And Function

Overview of the Structure and Function of the Blood-Brain Barrier in vivo

2001 ◽  
pp. 1-7 ◽  
Author(s):  
Joseph D. Fenstermacher ◽  
Tavarekere Nagaraja ◽  
Kenneth R. Davies
Keyword(s):  
Blood Brain Barrier ◽  
Structure And Function ◽  
Brain Barrier ◽  
Blood Brain ◽  
And Function

Breaking Bad: the Structure and Function of the Blood-Brain Barrier in Epilepsy

2017 ◽  
Vol 19 (4) ◽  
pp. 973-988 ◽  
Author(s):  
Hadas Han ◽  
Aniv Mann ◽  
Dana Ekstein ◽  
Sara Eyal
Keyword(s):  
Blood Brain Barrier ◽  
Structure And Function ◽  
Brain Barrier ◽  
Breaking Bad ◽  
Blood Brain ◽  
And Function

scholarly journals Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Song Ih Ahn ◽  
Yoshitaka J. Sei ◽  
Hyun-Ji Park ◽  
Jinhwan Kim ◽  
Yujung Ryu ◽  
...  
Keyword(s):  
Animal Models ◽  
Blood Brain Barrier ◽  
Neurological Diseases ◽  
Structure And Function ◽  
Brain Barrier ◽  
Cellular Interactions ◽  
Gene Expressions ◽  
Blood Brain ◽  
And Function

AbstractChallenges in drug development of neurological diseases remain mainly ascribed to the blood–brain barrier (BBB). Despite the valuable contribution of animal models to drug discovery, it remains difficult to conduct mechanistic studies on the barrier function and interactions with drugs at molecular and cellular levels. Here we present a microphysiological platform that recapitulates the key structure and function of the human BBB and enables 3D mapping of nanoparticle distributions in the vascular and perivascular regions. We demonstrate on-chip mimicry of the BBB structure and function by cellular interactions, key gene expressions, low permeability, and 3D astrocytic network with reduced reactive gliosis and polarized aquaporin-4 (AQP4) distribution. Moreover, our model precisely captures 3D nanoparticle distributions at cellular levels and demonstrates the distinct cellular uptakes and BBB penetrations through receptor-mediated transcytosis. Our BBB platform may present a complementary in vitro model to animal models for prescreening drug candidates for the treatment of neurological diseases.

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