Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective

2018 ◽  
pp. 319-341 ◽  
Author(s):  
Andrew R. Bogdan ◽  
Michael G. Organ
Keyword(s):  
Drug Discovery ◽  
Medicinal Chemistry ◽  
Flow Chemistry

Flow chemistry as a tool to access novel chemical space for drug discovery

2020 ◽  
Vol 12 (17) ◽  
pp. 1547-1563
Author(s):  
Enol López ◽  
María Lourdes Linares ◽  
Jesús Alcázar
Keyword(s):  
Drug Discovery ◽  
Medicinal Chemistry ◽  
Chemical Space ◽  
Flow Chemistry ◽  
Bioactive Molecules ◽  
Complex Molecules ◽  
Cycle Times

This perspective scrutinizes flow chemistry as a useful tool for medicinal chemists to expand the current chemical capabilities in drug discovery. This technology has demonstrated his value not only for the traditional reactions used in Pharma for the last 20 years, but also for bringing back to the lab underused chemistries to access novel chemical space. The combination with other technologies, such as photochemistry and electrochemistry, is opening new avenues for reactivity that will smoothen the access to complex molecules. The introduction of all these technologies in automated platforms will improve the productivity of medicinal chemistry labs reducing the cycle times to get novel and differentiated bioactive molecules, accelerating discovery cycle times.

scholarly journals Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3242 ◽  
Author(s):  
Marco Colella ◽  
Leonardo Degennaro ◽  
Renzo Luisi
Keyword(s):  
Drug Discovery ◽  
Continuous Flow ◽  
Medicinal Chemistry ◽  
Flow Chemistry ◽  
Modern Synthesis ◽  
Indole Derivatives ◽  
Flow Synthesis

Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis. In this review, the role of flow technology in the preparation of indole derivatives is showcased. Selected examples have been described with the aim to provide readers with an overview on the tactics and technologies used for targeting indole scaffolds.

Trifluoromethyl Ethers and –Thioethers as Tools for Medicinal Chemistry and Drug Discovery

2014 ◽  
Vol 14 (7) ◽  
pp. 941-951 ◽  
Author(s):  
Gregory Landelle ◽  
Armen Panossian ◽  
Frederic Leroux
Keyword(s):  
Drug Discovery ◽  
Medicinal Chemistry

scholarly journals John Macor is Awarded the 2020 IUPAC-Richter Prize

2020 ◽  
Vol 42 (2) ◽  
pp. 25-25
Keyword(s):  
Drug Discovery ◽  
Medicinal Chemistry

Abstract The 2020 IUPAC-Richter Prize in Medicinal Chemistry has been awarded to John Macor, PhD, Global Head Integrated Drug Discovery, Sanofi.

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