Burger's Medicinal Chemistry and Drug Discovery, 5th ed. Vol. 4. Therapeutic Agents Edited by Manfred E. Wolff (Technipharm Consultants). Wiley:  New York. 1997. vii + 656 pp. $225.00. ISBN 0-471-57559-3.

1998 ◽  
Vol 120 (13) ◽  
pp. 3273-3273
Author(s):  
Robert A. Faltynek
Keyword(s):  
New York ◽  
Drug Discovery ◽  
Medicinal Chemistry ◽  
Therapeutic Agents

scholarly journals The Impact of Microwave Irradiation Reaction in Medicinal Chemistry: A Review

2021 ◽  
Vol 37 (1) ◽  
pp. 01-24
Author(s):  
Ashutosh Pal ◽  
Krishnanka Shekhar Gayen
Keyword(s):  
Drug Discovery ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
Medicinal Chemistry ◽  
Rapid Evolution ◽  
Therapeutic Agents ◽  
Conventional Heating ◽  
Compound Libraries ◽  
The Impact ◽  
Better Than

The present review collects an update of the reactions in the area of medicinal chemistry using microwave irradiation. This review come up with an overview of most salient reactions performed under microwave irradiation in the field of drug discovery. Moreover, chemists are preferring to use this reaction rapidly in the academic as well as pharmaceutical laboratory during their drug discovery and making library of compounds. This reaction is much greener using less amount and readily recyclable solvents or sometimes reaction process without solvents and product become much cleaner, often yields are better than the conventional heating. Microwave irradiation is now very robust instrument used in company in the field of drug discovery, due to reduce the reaction time from hour to minute or even second and efficiently creation of compound libraries through combinatorial methodology associated with drug discovery so that new therapeutic agents bring to the market quicker. Hopefully, we will observe in the future the use of microwave irradiation drugs for the patients and this technology will utilize increase in number extensively in the field of medicinal chemistry. As this is an exceedingly rapid evolution area, this review offers significant expertise to the interested readers.

Analogue-based drug discovery: Contributions to medicinal chemistry principles and drug design strategies. Microtubule stabilizers as a case in point (Special Topic Article)

2012 ◽  
Vol 84 (7) ◽  
pp. 1479-1542 ◽  
Author(s):  
Mohammad H. El-Dakdouki ◽  
Paul W. Erhardt
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Medicinal Chemistry ◽  
Drug Distribution ◽  
Therapeutic Agents ◽  
Special Topic ◽  
Design Strategies ◽  
Basic Principles ◽  
Research Activities ◽  
Alternative Drug

The benefits of utilizing marketed drugs as starting points to discover new therapeutic agents have been well documented within the IUPAC series of books that bear the title Analogue-based Drug Discovery (ABDD). Not as clearly demonstrated, however, is that ABDD also contributes to the elaboration of new basic principles and alternative drug design strategies that are useful to the field of medicinal chemistry in general. After reviewing the ABDD programs that have evolved around the area of microtubule-stabilizing chemo-therapeutic agents, the present article delineates the associated research activities that additionally contributed to general strategies that can be useful for prodrug design, identifying pharmacophores, circumventing multidrug resistance (MDR), and achieving targeted drug distribution.

A Comprehensive Review on the Therapeutic Versatility of Imidazo [2,1-b]thiazoles

2020 ◽  
Vol 27 (40) ◽  
pp. 6864-6887 ◽  
Author(s):  
Mohd Adil Shareef ◽  
Irfan Khan ◽  
Bathini Nagendra Babu ◽  
Ahmed Kamal
Keyword(s):  
Literature Review ◽  
Medicinal Chemistry ◽  
Therapeutic Agents ◽  
Present Review ◽  
Thiazole Derivatives ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Derivatives Of

Background:: Imidazo[2,1-b]thiazole, a well-known fused five-membered hetrocycle is one of the most promising and versatile moieties in the area of medicinal chemistry. Derivatives of imidazo[2,1-b]thiazole have been investigated for the development of new derivatives that exhibit diverse pharmacological activities. This fused heterocycle is also a part of a number of therapeutic agents. Objective:: To review the extensive pharmacological activities of imidazo[2,1-b]thiazole derivatives and the new molecules developed between 2000-2018 and their usefulness. Method:: Thorough literature review of all relevant papers and patents was conducted. Conclusion:: The present review, covering a number of aspects, is expected to provide useful insights in the design of imidazo[2,1-b]thiazole-based compounds and would inspire the medicinal chemists for a comprehensive and target-oriented information to achieve a major breakthrough in the development of clinically viable candidates.

Trifluoromethyl Ethers and –Thioethers as Tools for Medicinal Chemistry and Drug Discovery

2014 ◽  
Vol 14 (7) ◽  
pp. 941-951 ◽  
Author(s):  
Gregory Landelle ◽  
Armen Panossian ◽  
Frederic Leroux
Keyword(s):  
Drug Discovery ◽  
Medicinal Chemistry
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