Skin Stem Cells, Their Niche and Tissue Engineering Approach for Skin Regeneration

2019 ◽  
pp. 107-126 ◽  
Author(s):  
Nur Kübra Çankirili ◽  
Ozlem Altundag ◽  
Betül Çelebi-Saltik
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Skin Regeneration ◽  
Engineering Approach ◽  
Tissue Engineering Approach

scholarly journals A Tissue Engineering Approach for Periodontal Regeneration Based on a Biodegradable Double-Layer Scaffold and Adipose-Derived Stem Cells

2014 ◽  
Vol 20 (17-18) ◽  
pp. 2483-2492 ◽  
Author(s):  
João F. Requicha ◽  
Carlos A. Viegas ◽  
Fernando Muñoz ◽  
Jorge M. Azevedo ◽  
Isabel B. Leonor ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Double Layer ◽  
Periodontal Regeneration ◽  
Adipose Derived Stem Cells ◽  
Engineering Approach ◽  
Tissue Engineering Approach

Tissue Engineering Approach to the Treatment of Bone Tumors: Three Cases of Cultured Bone Grafts Derived From Patients' Mesenchymal Stem Cells

2006 ◽  
Vol 30 (2) ◽  
pp. 115-118 ◽  
Author(s):  
Toru Morishita ◽  
Kanya Honoki ◽  
Hajime Ohgushi ◽  
Noriko Kotobuki ◽  
Asako Matsushima ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Tumors ◽  
Bone Grafts ◽  
Engineering Approach ◽  
Tissue Engineering Approach

A Patient-Inspired Ex Vivo Liver Tissue Engineering Approach with Autologous Mesenchymal Stem Cells and Hepatogenic Serum

2016 ◽  
Vol 5 (9) ◽  
pp. 1058-1070 ◽  
Author(s):  
Dillip K. Bishi ◽  
Santosh Mathapati ◽  
Jayarama R. Venugopal ◽  
Soma Guhathakurta ◽  
Kotturathu M. Cherian ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Tissue ◽  
Ex Vivo ◽  
Engineering Approach ◽  
Liver Tissue Engineering ◽  
Tissue Engineering Approach ◽  
Autologous Mesenchymal Stem Cells

TISSUE ENGINEERING APPROACH TO OSTEOCHONDRAL REPAIR AND REGENERATION

2004 ◽  
Vol 04 (04) ◽  
pp. 463-483 ◽  
Author(s):  
J. C. H. GOH ◽  
X. X. SHAO ◽  
D. W. HUTMACHER ◽  
E. H. LEE
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Clinical Medicine ◽  
Osteochondral Lesions ◽  
Fused Deposition ◽  
Engineering Approach ◽  
Osteochondral Scaffold ◽  
Osteochondral Repair ◽  
Tissue Engineering Approach

Repair of osteochondral lesions remains difficult in current clinical medicine. This is due to the lack of self-reparatory capacity in adult cartilage to respond to injuries. Furthermore, current surgical based treatment is unable to achieve long-term satisfactory results. Cell therapies combined with scaffolds has become a promising tissue engineering approach for osteochondral regeneration. This article briefly outlines the approaches and limitations in osteochondral tissue engineering from three key aspects, namely: (1) Cells and Cell Source; (2) Biomaterials and Scaffold design and fabrication; and (3) Mechanical and Biochemical Stimulus. Current optimal candidate cells for tissue engineering include bone marrow and adipose tissue derived mesenchymal stem cells. As for scaffolds, the structural design and biomaterials used should support cell growth and the organization of new functional tissue formation. Using Fused Deposition Modeling (FDM) technique, the authors developed a novel polycaprolactone osteochondral scaffold which was shown to have the ability to recruit mesenchymal stem cells and the potential for repairing defects in vivo. The article also discussed mechanical and biological stimulus for enhancing in vitro growth of tissue-engineered constructs. The final challenge is the integration of the tissue-engineered tissues into a living system as a functional device.

scholarly journals Hard Dental Tissues Regeneration—Approaches and Challenges

Materials ◽  
2021 ◽  
Vol 14 (10) ◽  
pp. 2558
Author(s):  
Mihaela Olaru ◽  
Liliana Sachelarie ◽  
Gabriela Calin
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Stem Cell ◽  
Growth Factors ◽  
Present Review ◽  
Modern Concept ◽  
Dental Tissues ◽  
Tissue Engineering Approach ◽  
Hard Dental Tissues ◽  
Review Reports

With the development of the modern concept of tissue engineering approach and the discovery of the potential of stem cells in dentistry, the regeneration of hard dental tissues has become a reality and a priority of modern dentistry. The present review reports the recent advances on stem-cell based regeneration strategies for hard dental tissues and analyze the feasibility of stem cells and of growth factors in scaffolds-based or scaffold-free approaches in inducing the regeneration of either the whole tooth or only of its component structures.

scholarly journals The Arteriovenous Loop: Engineering of Axially Vascularized Tissue

2018 ◽  
Vol 59 (3-4) ◽  
pp. 286-299 ◽  
Author(s):  
Annika Weigand ◽  
Raymund E. Horch ◽  
Anja M. Boos ◽  
Justus P. Beier ◽  
Andreas Arkudas
Keyword(s):  
Tissue Engineering ◽  
Large Scale ◽  
Treatment Options ◽  
Current Treatment ◽  
Loop Model ◽  
Engineering Approach ◽  
In Vivo Tissue Engineering ◽  
Tissue Engineering Approach ◽  
Tissue Defects

Background: Most of the current treatment options for large-scale tissue defects represent a serious burden for the patients, are often not satisfying, and can be associated with significant side effects. Although major achievements have already been made in the field of tissue engineering, the clinical translation in case of extensive tissue defects is only in its early stages. The main challenge and reason for the failure of most tissue engineering approaches is the missing vascularization within large-scale transplants. Summary: The arteriovenous (AV) loop model is an in vivo tissue engineering strategy for generating axially vascularized tissues using the own body as a bioreactor. A superficial artery and vein are anastomosed to create an AV loop. This AV loop is placed into an implantation chamber for prevascularization of the chamber inside, e.g., a scaffold, cells, and growth factors. Subsequently, the generated tissue can be transplanted with its vascular axis into the defect site and anastomosed to the local vasculature. Since the blood supply of the growing tissue is based on the AV loop, it will be immediately perfused with blood in the recipient site leading to optimal healing conditions even in the case of poorly vascularized defects. Using this tissue engineering approach, a multitude of different axially vascularized tissues could be generated, such as bone, skeletal or heart muscle, or lymphatic tissues. Upscaling from the small animal AV loop model into a preclinical large animal model could pave the way for the first successful attempt in clinical application. Key Messages: The AV loop model is a powerful tool for the generation of different axially vascularized replacement tissues. Due to minimal donor site morbidity and the possibility to generate patient-specific tissues variable in type and size, this in vivo tissue engineering approach can be considered as a promising alternative therapy to current treatment options of large-scale defects.

Sign in / Sign up

Export Citation Format

Share Document