Circulation of Influenza Virus in the 2015/2016 Epidemic Season in Poland: Serological Evaluation of Anti-hemagglutinin Antibodies

2018 ◽  
pp. 77-82 ◽  
Author(s):  
D. Kowalczyk ◽  
K. Szymański ◽  
K. Cieślak ◽  
E. Hallmann-Szelińska ◽  
L. B. Brydak
Keyword(s):  
Influenza Virus ◽  
Epidemic Season

scholarly journals Seasonal pattern of influenza and the association with meteorological factors based on wavelet analysis in Jinan City, Eastern China, 2013–2016

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e8626 ◽  
Author(s):  
Wei Su ◽  
Ti Liu ◽  
Xingyi Geng ◽  
Guoliang Yang
Keyword(s):  
Influenza Virus ◽  
Influencing Factors ◽  
Atmospheric Pressure ◽  
Meteorological Factors ◽  
Wavelet Coherence ◽  
Coherence Analysis ◽  
Climate Factors ◽  
Epidemic Season ◽  
Wavelet Coherence Analysis ◽  
Influenza Seasonality

Background Influenza is a disease under surveillance worldwide with different seasonal patterns in temperate and tropical regions. Previous studies have conducted modeling of influenza seasonality using climate variables. This study aimed to identify potential meteorological factors that are associated with influenza seasonality in Jinan, China. Methods Data from three influenza sentinel hospitals and respective climate factors (average temperature, relatively humidity (RH), absolute humidity (AH), sunshine duration, accumulated rainfall and speed of wind), from 2013 to 2016, were collected. Statistical and wavelet analyses were used to explore the epidemiological characteristics of influenza virus and its potential association with climate factors. Results The dynamic of influenza was characterized by annual cycle, with remarkable winter epidemic peaks from December to February. Spearman’s correlation and wavelet coherence analysis illuminated that temperature, AH and atmospheric pressure were main influencing factors. Multiple wavelet coherence analysis showed that temperature and atmospheric pressure might be the main influencing factors of influenza virus A(H3N2) and influenza virus B, whereas temperature and AH might best shape the seasonality of influenza virus A(H1N1)pdm09. During the epidemic season, the prevalence of influenza virus lagged behind the change of temperature by 1–8 weeks and atmospheric pressure by 0.5–3 weeks for different influenza viruses. Conclusion Climate factors were significantly associated with influenza seasonality in Jinan during the influenza epidemic season and the optional time for influenza vaccination is before November. These finding should be considered in influenza planning of control and prevention.

scholarly journals DRIFT OF INFLUENA A(H3N2) VIRUS: BIOLOGICAL, ANTIGENIC AND GENETIC PROPERTIES IN EPIDEMIC SEASON 2016-2017 IN RUSSIA AND COUNTRIES OF THE NOTHERN HEMYSPHERE

2018 ◽  
Vol 63 (2) ◽  
pp. 61-68 ◽  
Author(s):  
D. K. Lvov ◽  
E. I. Burtseva ◽  
E. S. Kirillova ◽  
L. V. Kolobukhina ◽  
E. A. Mukasheva ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Northern Hemisphere ◽  
Influenza A ◽  
H3n2 Virus ◽  
Research Centre ◽  
Federal State ◽  
Influenza B Virus ◽  
Influenza B ◽  
Epidemic Season ◽  
B Virus

The article presents the features of the influenza virus circulation for the period from October 2016 to May 2017 in some territories of Russia collaborating with the D.I. Ivanovsky Institute of Virology, Federal State Budgetary Institution “N.F. Gamaleya Federal Research Centre for Epidemiology and Microbiology”, Ministry of Health of the Russian Federation. One of the 2016-2017 season’s peculiarities in Russia and countries of the Northern hemisphere was the earlier start of an increase in ARD morbidity with peak indexes reached towards the end of December 2016 - January 2017. First, influenza A(H3N2) virus was predominant; then, it was followed by influenza B virus activity observed until the end of the season. The indexes of morbidity were higher than in the previous season, while the rates of hospitalization and mortality were lower, lethal cases being detected in persons 65 years old and older. Epidemic strains of influenza A(H3N2) virus belonged to 3c.2a genetic group, reference strain A/Hong Hong/4408/2014, and its subgroup 3c.2a1, reference A/Bolzano/7/2016, that are antigenically similar. Strains of influenza B virus were antigenically similar to the B/Brisbane/60/2008 vaccine virus. Strains were sensitive to oseltamivir and zanamivir. The share participation of non-influenza ARI viruses was similar to preliminary epidemic seasons. WHO has issued recommendations for influenza virus vaccines composition for 2017-2018 for the Northern hemisphere.

scholarly journals Development of live vaccine based on the Enterococcus faecium L3 vector for prevention influenza infections

2021 ◽  
Author(s):  
Yulia Desheva ◽  
Galina Leontieva ◽  
Tatiana Kramskaya ◽  
Tatiana Gupalova ◽  
Olga Kopteva ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Enterococcus Faecium ◽  
Influenza Infection ◽  
Probiotic Strain ◽  
Recombinant Vaccines ◽  
Local Immunity ◽  
Epidemic Season ◽  
The Third ◽  
Genes Encoding ◽  
Influenza Virus Neuraminidase

Abstract Probiotic microorganisms are currently considered as a promising platform for the development of recombinant vaccines expressing foreign antigens. In this study we generated and evaluated the live mucosal recombinant vaccine by integrating genes encoding influenza virus neuraminidase (NA) of N2 subtype into the DNA of the probiotic strain Enterococcus faecium L3 (L3). We confirmed NA expression in the pili of L3 using immune electron microscopy. Mice were fed with a probiotic vaccine containing the NA gene (L3-NA) or pure L3. Oral administration of L3-NA caused detectable increase of virus-specific serum IgG and local IgA after the third feeding. A the same time, single spleen cell suspensions were stimulated with whole A(H1N1)pdm09 virus followed by flow cytometry. In mice received L3-NA, the content of cytotoxic T-lymphocytes was more pronounced compared to mice receiving pure L3. Immunization with L3-NA increased the survival rate by 34% when the mice were infected using A(H1N1)pdm09 influenza virus after the third feeding. After S. pneumonia post-influenza infection, the L3-NA immunized mice were 50% more protected from lethality in comparison with L3 fed mice. Thus, a live probiotic vaccine candidate based on L3 induced the formation of systemic and local immunity and provide protection against complicated influenza. The approach based on a probiotic vaccine expressing viral epitopes can allow repeated immunization during epidemic season.

scholarly journals The Efficacy of Kampo Medicine as a Prophylactic Way to Influenza Virus Type A Infection in an Epidemic Season of 2004/05

2007 ◽  
Vol 58 (5) ◽  
pp. 847-852 ◽  
Author(s):  
Hisayuki HIRAIWA ◽  
Yoko OHTA ◽  
Rika HIRAIWA ◽  
Sachiko KANATSU ◽  
Yasushi HIROSE ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Type ◽  
Type A ◽  
Kampo Medicine ◽  
Epidemic Season

scholarly journals Molecular Epidemiology of A/H3N2 and A/H1N1 Influenza Virus during a Single Epidemic Season in the United States

2008 ◽  
Vol 4 (8) ◽  
pp. e1000133 ◽  
Author(s):  
Martha I. Nelson ◽  
Laurel Edelman ◽  
David J. Spiro ◽  
Alex R. Boyne ◽  
Jayati Bera ◽  
...  
Keyword(s):  
United States ◽  
Influenza Virus ◽  
Molecular Epidemiology ◽  
H1n1 Influenza ◽  
The United States ◽  
H1n1 Influenza Virus ◽  
Epidemic Season

scholarly journals DETECTION OF INFLUENZA VIRUS AND PATHOGENS OF ACUTE RESPIRATORY VIRAL INFECTIONS IN POPULATION OF KAZAKHSTAN DURING 2018-2019 EPIDEMIC SEASON

2019 ◽  
Author(s):  
N. G. Klivleyeva ◽  
N. S. Ongarbayeva ◽  
A. M. Baimukhametova ◽  
N. T. Saktaganov ◽  
G. V. Lukmanova ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Respiratory Syncytial Virus ◽  
Influenza A ◽  
Viral Infections ◽  
Influenza Viruses ◽  
Clinical Samples ◽  
Type B ◽  
Epidemic Season ◽  
Parainfluenza Viruses ◽  
Syncytial Virus

Influenza and other acute respiratory viral infections are the most common contemporary infectious diseases resulting in prominent harm to human health and great economic damage. At least five groups of viruses including more than 300 subtypes are currently referred to ARVI pathogens. Such infectious agents are characterized by variability resulting in their altered antigenic characteristics, increased contagiousness, "evasion from immune response and resistance to antivirals. Relevance of influenza and other ARVIs is also accounted for by rapid development of bacteria-associated respiratory diseases. Continuous variability of influenza viruses and emergence of new ARVI pathogens pose a serious threat. In recent years, a simultaneous circulation of subtype A (H1N1) and A (H3N2) influenza viruses with a predominance of a pandemic strain as well as type B viruses have been observed. Among the causative agents of non-influenza ARVIs, respiratory syncytial virus, rhino- and adenoviruses, and I/III parainfluenza viruses are recorded most often. Here we present the data of virology and serological examination of clinical samples collected during the 2018 – 2019 epidemic season in the Republic of Kazakhstan. For this, 2794 clinical samples (2530 nasopharyngeal swabs and 264 blood serums) were collected from patients diagnosed with ARVI, ARI, bronchitis, and pneumonia. Analysis of nasopharyngeal swabs for detection of influenza by RT-PCR demonstrated that mixed etiology influenza viruses with predominance of A/H1N1pdm virus circulated in Kazakhstan. The genetic fingerprints of influenza virus were found in 511 swabs (20.20% of total examined samples). Influenza A virus RNA was detected in 508 biological samples: A/H1N1 – in 289, A/H3N2 – in 209, and unidentified virus subtype in 10 samples. Type B influenza virus was detected in 3 samples. Study of 264 serum samples by HAI assay and ELISA showed emergence of antibodies against influenza A/H1N1, A/H3N2, and B viruses in residents from various regions of Kazakhstan that indirectly confirmed co-circulation of these viruses. 42 influenza virus strains were isolated in chicken embryos, from which 28 were assigned to A/H1N1pdm virus, 13 to A/H3N2 virus, and one isolate was identified as influenza B virus. Laboratory diagnostics of clinical samples for ARVIs established that among identified non-influenza agents respiratory syncytial virus dominated, while rhinoviruses and adenoviruses were less common. Metapneumoviruses, bocaviruses, coronaviruses, and type I parainfluenza viruses were detected in few cases. Comparison of study data with those obtained after examining circulation of influenza viruses during the 2017 – 2018 epidemic season showed that in 2018 – 2019 in Kazakhstan similar to the previous epidemic season, influenza A and B viruses continued to circulate, with prevalence of A/H1N1pdm virus. Identification of non-influenza viruses causing respiratory infections in 2018 – 2019 showed predominance of respiratory syncytial virus, which correlated with data on the 2017 – 2018 epidemic season.

scholarly journals Influenza and Influenza-Like Illnesses in Poland in the Epidemic Season 2010/2011 According to the SENTINEL Influenza Surveillance System

2013 ◽  
Vol 62 (1) ◽  
pp. 51-58
Author(s):  
MAGDALENA ROMANOWSKA ◽  
ILONA STEFAŃSKA ◽  
LIDIA B. BRYDAK
Keyword(s):  
Influenza Virus ◽  
Surveillance System ◽  
Influenza A ◽  
Influenza Surveillance ◽  
Influenza B ◽  
Influenza Like Illness ◽  
Epidemic Season ◽  
Specimen Collection ◽  
Analyze Data ◽  
Virus Influenza

The aim of this study was to analyze data collected by the SENTINEL influenza surveillance system in Poland in the first post-pandemic season 2010/2011. The results include weeks 35/2010-17/2011. Physicians registered weekly number of influenza-like illnesses and collected specimens. Laboratory tests were done using PCR and/or real-time PCR or immunofluorescence. Laboratories also isolated the influenza virus. Influenza-like illness incidence amounted to 2802.7/100000. Weekly incidence ranged from 11.3/100000 to 232/100000. The most affected group was children 0-4 years. Influenza-like illness peak occurred between weeks 02/2011 and 11/2011. Influenza infections were confirmed in 34.9% of specimens. More cases were caused by influenza A, including A(H1N1)pdm09 than influenza B (59.9% vs. 40.1%). The isolated strains were similar to A/California/7/2009 or B/Brisbane/60/2008. Season 2010/2011 in Poland did not differ from the rest of Europe. Further improvement is necessary, especially in the area of specimen collection at the beginning of an epidemic season and carrying out the isolation of the influenza virus.

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