Long-Term Exposure to Ambient Air Pollution in Childhood-Adolescence and Lung Function in Adulthood

2018 ◽  
pp. 19-26 ◽  
Author(s):  
A. Dubrowski ◽  
K. Kliś ◽  
M. Żurawiecka ◽  
K. Dereń ◽  
M. Barszcz ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Ambient Air ◽  
Ambient Air Pollution

Long-Term Effects of Ambient Air Pollution on Lung Function

Epidemiology ◽  
2008 ◽  
Vol 19 (5) ◽  
pp. 690-701 ◽  
Author(s):  
Thomas Götschi ◽  
Joachim Heinrich ◽  
Jordi Sunyer ◽  
Nino Künzli
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Long Term Effects

scholarly journals Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis

2014 ◽  
Vol 45 (1) ◽  
pp. 38-50 ◽  
Author(s):  
Martin Adam ◽  
Tamara Schikowski ◽  
Anne Elie Carsin ◽  
Yutong Cai ◽  
Benedicte Jacquemin ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Meta Analysis ◽  
Ambient Air ◽  
Coarse Fraction ◽  
Forced Expiratory Volume ◽  
Ambient Air Pollution ◽  
Longitudinal Change ◽  
Pollution Effects

The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE).Residential exposure to nitrogen oxides (NO2, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis.We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m−3 increase in NO2 exposure was associated with lower levels of FEV1 (−14.0 mL, 95% CI −25.8 to −2.1) and FVC (−14.9 mL, 95% CI −28.7 to −1.1). An increase of 10 μg·m−3 in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (−44.6 mL, 95% CI −85.4 to −3.8) and FVC (−59.0 mL, 95% CI −112.3 to −5.6). The associations were particularly strong in obese persons.This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.

scholarly journals Association Between Long-term Exposure to Ambient Air Pollution and Change in Quantitatively Assessed Emphysema and Lung Function

JAMA ◽  
2019 ◽  
Vol 322 (6) ◽  
pp. 546 ◽  
Author(s):  
Meng Wang ◽  
Carrie Pistenmaa Aaron ◽  
Jaime Madrigano ◽  
Eric A. Hoffman ◽  
Elsa Angelini ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Ambient Air ◽  
Ambient Air Pollution

scholarly journals Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study

2016 ◽  
Vol 49 (1) ◽  
pp. 1600206 ◽  
Author(s):  
Meriem Benmerad ◽  
Rémy Slama ◽  
Karine Botturi ◽  
Johanna Claustre ◽  
Antoine Roux ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Lung Transplantation ◽  
Air Pollutants ◽  
Chronic Exposure ◽  
Ambient Air ◽  
Forced Expiratory Volume ◽  
Ambient Air Pollution ◽  
Lung Transplant Recipients

An irreversible loss in lung function limits the long-term success in lung transplantation. We evaluated the role of chronic exposure to ambient air pollution on lung function levels in lung transplant recipients (LTRs).The lung function of 520 LTRs from the Cohort in Lung Transplantation (COLT) study was measured every 6 months. The levels of air pollutants (nitrogen dioxide (NO2), particulate matter with an aerodynamic cut-off diameter of x µm (PMx) and ozone (O3)) at the patients' home address were averaged in the 12 months before each spirometry test. The effects of air pollutants on forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in % predicted were estimated using mixed linear regressions. We assessed the effect modification of macrolide antibiotics in this relationship.Increased 12-month levels of pollutants were associated with lower levels of FVC % pred (−2.56%, 95% CI −3.86–−1.25 for 5 µg·m−3of PM10; −0.75%, 95% CI −1.38–−0.12 for 2 µg·m−3of PM2.5and −2.58%, 95% CI −4.63–−0.53 for 10 µg·m−3of NO2). In patients not taking macrolides, the deleterious association between PM and FVC tended to be stronger and PM10was associated with lower FEV1.Our study suggests a deleterious effect of chronic exposure to air pollutants on lung function levels in LTRs, which might be modified with macrolides.

scholarly journals Long-term exposure to PM10 and NO2 in relation to lung function and imaging phenotypes in a COPD cohort

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Sung Ok Kwon ◽  
Seok Ho Hong ◽  
Young-Ji Han ◽  
So Hyeon Bak ◽  
Junghyun Kim ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Quantitative Imaging ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Linear Regression Models ◽  
Wall Area ◽  
Study Participants ◽  
Area Percent

Abstract Background Ambient air pollution can contribute to the development and exacerbation of COPD. However, the influence of air pollution on objective COPD phenotypes, especially from imaging, is not well studied. We investigated the influence of long-term exposure to air pollution on lung function and quantitative imaging measurements in a Korean cohort of participants with and without COPD diagnosis. Methods Study participants (N = 457 including 296 COPD cases) were obtained from the COPD in Dusty Areas (CODA) cohort. Annual average concentrations of particulate matter less than or equal to 10 μm in diameter (PM10) and nitrogen dioxide (NO2) were estimated at the participants’ residential addresses using a spatial air pollution prediction model. All the participants underwent volumetric computerized tomography (CT) and spirometry measurements and completed survey questionnaires. We examined the associations of PM10 and NO2 with FVC, FEV1, emphysema index, and wall area percent, using linear regression models adjusting for age, gender, education, smoking, height, weight, and COPD medication. Results The age of study participants averaged 71.7 years. An interquartile range difference in annual PM10 exposure of 4.4 μg/m3 was associated with 0.13 L lower FVC (95% confidence interval (CI), − 0.22- -0.05, p = 0.003). Emphysema index (mean = 6.36) was higher by 1.13 (95% CI, 0.25–2.02, p = 0.012) and wall area percent (mean = 68.8) was higher by 1.04 (95% CI, 0.27–1.80, p = 0.008). Associations with imaging phenotypes  were not observed with NO2. Conclusions Long-term exposure to PM10 correlated with both lung function and COPD-relevant imaging phenotypes in a Korean cohort.

scholarly journals Systemic Inflammation (C-Reactive Protein) in Older Chinese Adults Is Associated with Long-Term Exposure to Ambient Air Pollution

2021 ◽  
Vol 18 (6) ◽  
pp. 3258
Author(s):  
Mona Elbarbary ◽  
Artem Oganesyan ◽  
Trenton Honda ◽  
Geoffrey Morgan ◽  
Yuming Guo ◽  
...  
Keyword(s):  
Air Pollution ◽  
Systemic Inflammation ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Chinese Adults ◽  
Reactive Protein ◽  
Hs Crp ◽  
Older Chinese ◽  
Older Chinese Adults

There is an established association between air pollution and cardiovascular disease (CVD), which is likely to be mediated by systemic inflammation. The present study evaluated links between long-term exposure to ambient air pollution and high-sensitivity C reactive protein (hs-CRP) in an older Chinese adult cohort (n = 7915) enrolled in the World Health Organization (WHO) study on global aging and adult health (SAGE) China Wave 1 in 2008–2010. Multilevel linear and logistic regression models were used to assess the associations of particulate matter (PM) and nitrogen dioxide (NO2) on log-transformed hs-CRP levels and odds ratios of CVD risk derived from CRP levels adjusted for confounders. A satellite-based spatial statistical model was applied to estimate the average community exposure to outdoor air pollutants (PM with an aerodynamic diameter of 10 μm or less (PM10), 2.5 μm or less (PM2.5), and 1 μm or less (PM1) and NO2) for each participant of the study. hs-CRP levels were drawn from dried blood spots of each participant. Each 10 μg/m3 increment in PM10, PM2.5, PM1, and NO2 was associated with 12.8% (95% confidence interval; (CI): 9.1, 16.6), 15.7% (95% CI: 10.9, 20.8), 10.2% (95% CI: 7.3, 13.2), and 11.8% (95% CI: 7.9, 15.8) higher serum levels of hs-CRP, respectively. Our findings suggest that air pollution may be an important factor in increasing systemic inflammation in older Chinese adults.

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