scholarly journals Regional Diversification of Influenza Activity in Poland During the 2015/16 Epidemic Season

2017 ◽  
pp. 1-6 ◽  
Author(s):  
K. Szymański ◽  
D. Kowalczyk ◽  
K. Cieślak ◽  
L. B. Brydak
Keyword(s):  
Epidemic Season ◽  
Influenza Activity ◽  
Regional Diversification

Preliminary results of the epidemic season 2015–2016. Influenza and SARS in the Russian Federation

2016 ◽  
Vol 18 (3) ◽  
pp. 8-11 ◽  
Author(s):  
A.Yu. Popova ◽  
◽  
E.B. Ezhlova ◽  
A.A. Melnikova ◽  
N.V. Frolova ◽  
...  
Keyword(s):  
Russian Federation ◽  
Epidemic Season ◽  
Preliminary Results ◽  
The Russian Federation

Refining the Analysis of Regional Diversification for Income-Producing Real Estate

1987 ◽  
Vol 2 (2) ◽  
pp. 85-95 ◽  
Author(s):  
David Hartzell ◽  
David Shulman ◽  
Charles Wurtzebach
Keyword(s):  
Real Estate ◽  
Regional Diversification

scholarly journals Differential Influence of Age on the Relationship between Genetic Mismatch and A(H1N1)pdm09 Vaccine Effectiveness

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 619
Author(s):  
Lirong Cao ◽  
Shi Zhao ◽  
Jingzhi Lou ◽  
Hong Zheng ◽  
Renee W. Y. Chan ◽  
...  
Keyword(s):  
Age Groups ◽  
The Elderly ◽  
Vaccine Effectiveness ◽  
Amino Acid Mutation ◽  
Epidemic Season ◽  
Vaccine Component ◽  
Linear Relationships ◽  
The Difference ◽  
Middle Aged Adults ◽  
The Relationship

Assessment of influenza vaccine effectiveness (VE) and identification of relevant influencing factors are the current priorities for optimizing vaccines to reduce the impacts of influenza. To date, how the difference between epidemic strains and vaccine strains at genetic scale affects age-specific vaccine performance remains ambiguous. This study investigated the association between genetic mismatch on hemagglutinin and neuraminidase genes and A(H1N1)pdm09 VE in different age groups with a novel computational approach. We found significant linear relationships between VE and genetic mismatch in children, young adults, and middle-aged adults. In the children’s group, each 3-key amino acid mutation was associated with an average of 10% decrease in vaccine effectiveness in a given epidemic season, and genetic mismatch exerted no influence on VE for the elderly group. We demonstrated that present vaccines were most effective for children, while protection for the elderly was reduced and indifferent to vaccine component updates. Modeling such relationships is practical to inform timely evaluation of VE in different groups of populations during mass vaccination and may inform age-specific vaccination regimens.

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