scholarly journals Differential Influence of Age on the Relationship between Genetic Mismatch and A(H1N1)pdm09 Vaccine Effectiveness

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 619
Author(s):  
Lirong Cao ◽  
Shi Zhao ◽  
Jingzhi Lou ◽  
Hong Zheng ◽  
Renee W. Y. Chan ◽  
...  
Keyword(s):  
Age Groups ◽  
The Elderly ◽  
Vaccine Effectiveness ◽  
Amino Acid Mutation ◽  
Epidemic Season ◽  
Vaccine Component ◽  
Linear Relationships ◽  
The Difference ◽  
Middle Aged Adults ◽  
The Relationship

Assessment of influenza vaccine effectiveness (VE) and identification of relevant influencing factors are the current priorities for optimizing vaccines to reduce the impacts of influenza. To date, how the difference between epidemic strains and vaccine strains at genetic scale affects age-specific vaccine performance remains ambiguous. This study investigated the association between genetic mismatch on hemagglutinin and neuraminidase genes and A(H1N1)pdm09 VE in different age groups with a novel computational approach. We found significant linear relationships between VE and genetic mismatch in children, young adults, and middle-aged adults. In the children’s group, each 3-key amino acid mutation was associated with an average of 10% decrease in vaccine effectiveness in a given epidemic season, and genetic mismatch exerted no influence on VE for the elderly group. We demonstrated that present vaccines were most effective for children, while protection for the elderly was reduced and indifferent to vaccine component updates. Modeling such relationships is practical to inform timely evaluation of VE in different groups of populations during mass vaccination and may inform age-specific vaccination regimens.

Relationship between the Differences of Odor Detection Threshold Values Measured by Different Methods and some of the Physicochemical Properties

2013 ◽  
Vol 807-809 ◽  
pp. 451-455 ◽  
Author(s):  
Di Fang ◽  
Jie Min Liu ◽  
Qin Yi
Keyword(s):  
Physicochemical Properties ◽  
Functional Group ◽  
Saturated Vapor ◽  
Detection Threshold ◽  
Threshold Values ◽  
Odor Detection ◽  
Linear Relationships ◽  
Odor Detection Threshold ◽  
The Difference ◽  
The Relationship

The amount of sample can enter the nasal cavity depends on the physiochemical characteristics such as distribution, volatility and solubility. It can be suspected that the difference of odor detection threshold (ODT) measured by different methods is related to the physicochemical properties of compounds. To investigate the relationship between ODT differences and the physicochemical properties of compounds, ODT values of four series of organic compounds were measured by triangle odor bag method and gas chromatography and olfactometry method; the results were compared and the absolute differences were calculated. Relationship between ODT differences and the type of functional group and some of the physicochemical properties of compounds was analyzed. The results showed the type of functional group had significant effect on the differences. Certain linear relationships between the logarithmic value of differences and the logarithmic values of saturated vapor pressure and molecular weight were observed.

Measurement error-filtered machine learning in digital soil mapping

2021 ◽  
Author(s):  
Stephan van der Westhuizen ◽  
Gerard Heuvelink ◽  
David Hofmeyr
Keyword(s):  
Machine Learning ◽  
Measurement Error ◽  
Soil Property ◽  
Soil Mapping ◽  
Digital Soil Mapping ◽  
Simulation Studies ◽  
True Value ◽  
Linear Relationships ◽  
The Difference ◽  
The Relationship

<p>Digital soil mapping (DSM) may be defined as the use of a statistical model to quantify the relationship between a certain observed soil property at various geographic locations, and a collection of environmental covariates, and then using this relationship to predict the soil property at locations where the property was not measured. It is also important to quantify the uncertainty with regards to prediction of these soil maps. An important source of uncertainty in DSM is measurement error which is considered as the difference between a measured and true value of a soil property.</p><p>The use of machine learning (ML) models such as random forests (RF) has become a popular trend in DSM. This is because ML models tend to be capable of accommodating highly non-linear relationships between the soil property and covariates. However, it is not clear how to incorporate measurement error into ML models. In this presentation we will discuss how to incorporate measurement error into some popular ML models, starting with incorporating weights into the objective function of ML models that implicitly assume a Gaussian error. We will discuss the effect that these modifications have on prediction accuracy, with reference to simulation studies.</p>

scholarly journals Assessment of functional capacity in elderly residents of an outlying area in the hinterland of Bahia/Northeast Brazil

2010 ◽  
Vol 68 (1) ◽  
pp. 39-43 ◽  
Author(s):  
Gilson de Vasconcelos Torres ◽  
Luciana Araújo dos Reis ◽  
Luana Araújo dos Reis
Keyword(s):  
Activities Of Daily Living ◽  
Functional Capacity ◽  
Daily Living ◽  
Age Groups ◽  
The Elderly ◽  
Cross Sectional ◽  
Instrumental Activities ◽  
Significant Difference ◽  
The Difference ◽  
Outlying Area

OBJECTIVE: To assess the functional capacity and to determine the difference between the means of functional capacity (basic and instrumental activities of daily living) and the age groups of elderly residents in an outlying area in the hinterland of Bahia/Northeast of Brazil. METHOD: Analytical study with cross-sectional design and a sample of 150 elderly individuals enrolled in four Health Units in the municipality of Jequié, Bahia, Brazil. The instrument consisted of sociodemographic and health data, the Barthel Index and the Lawton scale. RESULTS: In all, 78.00% of the elderly were classified as dependent in the basic activities and 65.33% in the instrumental activities of daily living. Using the Kruskal-Wallis test, we found a statistically significant difference between the means of instrumental activities and the age groups (p=0.011). CONCLUSION: An elevated number of elderly were classified as dependent in terms of functional capacity and increased age is related to greater impairment in the execution of instrumental activities of daily living.

scholarly journals Barriers and Motivators of Physical Activity Participation in Middle-Aged and Older Adults—A Systematic Review

2019 ◽  
Vol 27 (6) ◽  
pp. 929-944 ◽  
Author(s):  
Karl Spiteri ◽  
David Broom ◽  
Amira Hassan Bekhet ◽  
John Xerri de Caro ◽  
Bob Laventure ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Social Influences ◽  
Age Groups ◽  
Middle Aged ◽  
Quantitative Studies ◽  
The Difference ◽  
Middle Aged Adults ◽  
Health Promotion Interventions ◽  
Barriers And Motivators

Identifying the difference in the barriers and motivators between middle-aged and older adults could contribute toward the development of age-specific health promotion interventions. The aim of this review was to synthesize the literature on the barriers and motivators for physical activity in middle-aged (50–64 years) and older (65–70 years) adults. This review examined qualitative and quantitative studies using the theoretical domain framework as the guiding theory. The search generated 9,400 results from seven databases, and 55 articles meeting the inclusion criteria were included. The results indicate that the barriers are comparable across the two age groups, with environmental factors and resources being the most commonly identified barriers. In older adults, social influences, reinforcement, and assistance in managing change were the most identified motivators. In middle-aged adults, goal-setting, the belief that an activity will be beneficial, and social influences were identified as the most important motivators. These findings can be used by professionals to encourage engagement with and adherence to physical activity.

scholarly journals Relationship between Maximum Tongue Pressure Value and Age, Occlusal Status, or Body Mass Index among the Community-Dwelling Elderly

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 623
Author(s):  
Hiroki Suzuki ◽  
Yasunori Ayukawa ◽  
Yoko Ueno ◽  
Ikiru Atsuta ◽  
Akio Jinnouchi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
The Elderly ◽  
Community Dwelling ◽  
Tongue Pressure ◽  
Term Care ◽  
Younger Age ◽  
The Difference ◽  
The Relationship

Background and objectives: In an aging society, the maintenance of the oral function of the elderly is of importance for the delay or prevention of frailty and long-term care. In the present study, we focused on the maximum tongue pressure (MTP) value and analyzed the relationship between MTP and age, occlusal status, or body mass index (BMI). Materials and Methods: This one-center observatory study was conducted using a cohort consisting of 205 community-dwelling outpatients over 65 years old. The MTP values of all subjects were measured using a commercially available tongue pressure measurement device and statistically analyzed. In addition, the correlation between MTP value and BMI was analyzed. Results: The MTP value decreased with age, especially in subjects classified as Eichner B and C. The difference in occlusal status did not show any statistically significant influence on MTP value. The correlation between BMI and MTP value was indicated in the tested groups other than an age of 65–74 and Eichner A groups. Conclusions: Although MTP value decreased with age, the difference in occlusal status did not have an impact on MTP value. The correlation between BMI and MTP value was not shown in the youngest group or a group with sufficient occlusal units. The results presented in the present study may imply that, even if MTP is low, younger age and/or better occlusal status compensate for the inferior MTP value in the cohort studied.

scholarly journals Age-Related Changes in the 25-Hydroxyvitamin D Versus Parathyroid Hormone Relationship Suggest a Different Reason Why Older Adults Require More Vitamin D

2003 ◽  
Vol 88 (1) ◽  
pp. 185-191 ◽  
Author(s):  
Reinhold Vieth ◽  
Yasmin Ladak ◽  
Paul G. Walfish
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Age Groups ◽  
The Elderly ◽  
Age Group ◽  
Hydroxyvitamin D ◽  
Age Related ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Vitamin D requirements are thought to vary with age, but there is little comparative evidence for this. One goal in establishing a vitamin D requirement is to avoid secondary hyperparathyroidism. We studied 1741 euthyroid, thyroid clinic outpatients without evidence of calcium abnormalities, ranging in age from 19 to 97 yr, whose serum and urine had been analyzed for calcium, vitamin D, and parathyroid status. We found no effect of age on the 25-hydroxyvitamin D [25(OH)D] concentration associated with specific vitamin D intakes, and there was no relationship between 25(OH)D and 1,25hydroxyvitamin D [1,25(OH)2D]. In every age group, serum 1,25(OH)2D declined with increasing creatinine (P < 0.001). What changed with age included creatinine, which correlated with 25(OH)D (r = 0.146, P < 0.001) only in the youngest age group (19–50 yr) but not in the older age groups (P > 0.1). Creatinine did not correlate with PTH in the youngest age group, but the relationship became significant as age increased (e.g. for the elderly, r = 0.365, P < 0.001). Linear regression of log PTH vs. log 25(OH)D agreed with the natural shape of the relationship observed with scatterplot smoothing, and this showed no plateau in PTH as 25(OH)D increased. We compared PTH concentrations among age groups, based on 20 nmol/liter increments in 25(OH)D. Mean PTH in adults older than 70 yr was consistently higher than in adults younger than 50 yr (P < 0.05 by ANOVA and Dunnett’s t test). PTH levels of the elderly who had 25(OH)D concentrations greater than 100 nmol/liter matched PTH of younger adults having 25(OH)D concentrations near 70 nmol/liter. This study shows that all age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism. Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function.

Humoral immunity to respiratory syncytial virus in young and elderly adults

2009 ◽  
Vol 137 (12) ◽  
pp. 1684-1686 ◽  
Author(s):  
C. TERROSI ◽  
G. Di GENOVA ◽  
B. MARTORELLI ◽  
M. VALENTINI ◽  
M. G. CUSI
Keyword(s):  
Respiratory Syncytial Virus ◽  
Neutralizing Antibodies ◽  
Serum Antibody ◽  
Age Groups ◽  
The Elderly ◽  
Elderly Subjects ◽  
Rsv Infection ◽  
Syncytial Virus ◽  
Relationship Of ◽  
The Relationship

SUMMARYRespiratory syncytial virus (RSV) has been demonstrated to cause substantial disease in elderly and immunocompromised subjects. The relationship of serum antibody to RSV infection and the risk of infection in elderly subjects is controversial, thus we evaluated the presence of neutralizing antibodies to RSV in healthy people of different age groups and the correlation with viral protection. Baseline blood samples from 197 subjects aged 20–80 years were analysed for the presence of anti-RSV antibodies either by indirect immunofluorescence and microneutralization test. The percentage of people who had neutralizing antibodies to RSV was significantly higher (P=0·001) in the youngest group (92·51%) compared to the frail group (36·21%). The RSV antibody level tends to wane in some older people; this factor could determine proneness to RSV re-infections in the elderly who are at a greater risk of developing severe respiratory disease.

scholarly journals Contestation of Perspectives Toward Suicide in The Film Monsieur Lazhar (2011) by Philippe Falardeau

2021 ◽  
Vol 5 (1) ◽  
pp. 1
Author(s):  
Tesya Imanisa Setiadi ◽  
Wening Udasmoro ◽  
Hayatul Cholsy
Keyword(s):  
Causes Of Death ◽  
Age Groups ◽  
Young Age ◽  
Age Group ◽  
Adult Age ◽  
Personal Experiences ◽  
The Difference ◽  
Relationship Of ◽  
The Relationship ◽  
Keywords Suicide

Abstract. Suicide is one of the causes of death that occurs in a global scope but always causes divisive perspectives in various circles of society. For most people, suicide is a taboo topic, but not for other groups. The film Monsieur Lazhar (2011) is a film that shows the different perspectives between different age groups, namely the adult age group and the young age group, on a suicide that occurred at an elementary school in Montreal, Canada. This study aims at determining the different perspectives of the two different parties on suicide and the reasons for these differences in views. Pierre Bourdieu’s Champ de Force theory is the lens used in this research. The difference in perspective is influenced by the disposition system which Bourdieu calls the habitus. Habitus operates in a realm (champ). In the film, the domain in question is school. Meanwhile, Durkheim’s theory of suicide was chosen to determine the relationship of social problems to suicide. The method used in this research is content analysis. The data used are the chronological text of the scenes and the transcript of the conversations from the film. From the research, it was found that the school, which is the adult age group, has a counter and stigmatic view of suicide, reinforced by perceptions of psychological problems and social taboos. Meanwhile, students, who are in the young age group, tend to view suicide as a problem related to personal aspects and personal experiences so that they do not have a judgmental attitude like the school. Keywords : Suicide, Contestation, Realm, Perspective, Habitus

scholarly journals The specificity of the relationship of interpersonal relationship and self-relationship of the elderly

2019 ◽  
pp. 57-61
Author(s):  
Dmitriy V. Ganin
Keyword(s):  
Elderly People ◽  
Interpersonal Relationships ◽  
Interpersonal Relations ◽  
Interpersonal Relationship ◽  
Age Groups ◽  
The Elderly ◽  
Age Group ◽  
Relationship Of ◽  
Inclusion Control ◽  
The Relationship

This article discusses the results of an empirical, comprehensive study of interpersonal relationships and self-relation of older people. Special attention is paid tointerpersonal needs. The author notes, in the age group of elderly people, the presence of all kinds of interpersonal needs, inclusion, control, affect. This is not observed in the middle and senile age groups. The age interrelation between interpersonal relations and self-attitude of elderly people is found out. The study found correlations characteristic of the age group of the elderly and other age groups, namely: the similarity of the correlations of the elderly and middle-aged and elderly and senile. The most important need characteristic of older persons as the need for "inclusion"was also identified.

scholarly journals SPENDING PATTERNS ON MILLENNIAL GENERATION IN SURABAYA

2021 ◽  
Vol 2 (1) ◽  
pp. 20-26
Author(s):  
Mariana Ing Malelak ◽  
Nathania Mirabel Halim
Keyword(s):  
Significant Relationship ◽  
Millennial Generation ◽  
Age Groups ◽  
T Test ◽  
Spending Patterns ◽  
Analysis Technique ◽  
Significant Difference ◽  
The Difference ◽  
The Relationship ◽  
Two Age Groups

This study aims to examine spending patterns in the millennial generation in Surabaya. Respondents of this study were the millennial generation who were divided into two age groups, namely 21-28 years old, who were referred to as junior millennials, and those aged 29-36 years who were referred to as senior millennials. The analysis technique used is a crosstab to examine the relationship between age and spending pattern of the millennial generation and an independent-sample t-test to test the difference between the spending pattern of the junior millennials and senior millennials. This study showed a significant relationship between age and spending pattern on the millennial generation, and there is a significant difference between the spending pattern of the junior millennials and senior millennials.

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