Pharmacokinetics and Pharmacodynamics of Drugs in Obese Pediatric Patients: How to Map Uncharted Clinical Territories

2019 ◽  
pp. 231-255
Author(s):  
Elke H. J. Krekels ◽  
Catherijne A. J. Knibbe
Keyword(s):  
Pediatric Patients ◽  
Pharmacokinetics And Pharmacodynamics

Pharmacokinetics and Pharmacodynamics of Bumetanide in Critically Ill Pediatric Patients

1998 ◽  
Vol 38 (11) ◽  
pp. 994-1002 ◽  
Author(s):  
James D. Marshall ◽  
Thomas G. Wells ◽  
Lynda Letzig ◽  
Gregory L. Kearns
Keyword(s):  
Critically Ill ◽  
Pediatric Patients ◽  
Pharmacokinetics And Pharmacodynamics

scholarly journals Key Potentially Inappropriate Drugs in Pediatrics: The KIDs List

2020 ◽  
Vol 25 (3) ◽  
pp. 175-191 ◽  
Author(s):  
Rachel S. Meyers ◽  
Jennifer Thackray ◽  
Kelly L. Matson ◽  
Christopher McPherson ◽  
Lisa Lubsch ◽  
...  
Keyword(s):  
English Language ◽  
Pediatric Patients ◽  
Adverse Drug Events ◽  
Product Information ◽  
Case Reports ◽  
Standard Of Care ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Inappropriate Drugs ◽  
Drug Classes ◽  
Pubmed Search

OBJECTIVES The safe use of medications in pediatric patients requires practitioners to consider the unique pharmacokinetics and pharmacodynamics of drugs prescribed in this age group. In an effort to create a standard of care for the safe use of medications in this population, a list of drugs that are potentially inappropriate for use in pediatric patients has been developed and titled the “KIDs List.” METHODS A panel of 7 pediatric pharmacists from the Pediatric Pharmacy Association were recruited to evaluate primary, secondary, and tertiary literature; FDA Pediatric Safety Communications; the Lexicomp electronic database; and product information for drugs that should be considered potentially inappropriate for use in pediatric patients. Information was rated using predefined criteria. A PubMed search was conducted using the following terms: adverse drug events OR adverse drug reactions. The search was limited to humans; age <18 years; case reports, observational studies, or clinical trials; and English language. No date range was used. Results were used to create an evidence-based list of candidate drugs that was then peer-reviewed and subjected to a 30-day public comment period prior to being finalized. RESULTS A PubMed search yielded 4049 unique titles, of which 210 were deemed relevant for full review. Practitioner recommendations highlighted an additional 77 drugs. FDA Pediatric Safety Communications and the Lexicomp database yielded 22 and 619 drugs, respectively. After critical analysis, peer review, and public review the final KIDs List contains 67 drugs and/or drug classes and 10 excipients. CONCLUSIONS This extensive effort led to compilation of the first list of drugs that are potentially inappropriate for prescribing in all or in a select subgroup of pediatric patients. If avoidance is not clinically possible, the drug should be used with caution and accompanied by appropriate monitoring.

scholarly journals PHARMACOKINETICS AND PHARMACODYNAMICS OF MILRINONE LACTATE IN PEDIATRIC PATIENTS WITH SEPTIC SHOCK. † 288

1996 ◽  
Vol 39 ◽  
pp. 50-50
Author(s):  
Christine A Lindsay ◽  
Phil Barton ◽  
Stephen Lawless ◽  
Louann Kitchen ◽  
Amy Zorka ◽  
...  
Keyword(s):  
Septic Shock ◽  
Pediatric Patients ◽  
Pharmacokinetics And Pharmacodynamics

Linezolid dosage in pediatric patients based on pharmacokinetics and pharmacodynamics

2015 ◽  
Vol 21 (1) ◽  
pp. 70-73 ◽  
Author(s):  
Kazuaki Matsumoto ◽  
Akari Shigemi ◽  
Ayumi Takeshita ◽  
Erika Watanabe ◽  
Yuta Yokoyama ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Pharmacokinetics And Pharmacodynamics

Pharmacokinetics and pharmacodynamics of canagliflozin in pediatric patients with type 2 diabetes

2017 ◽  
Vol 19 (4) ◽  
pp. 649-655 ◽  
Author(s):  
William V Tamborlane ◽  
David Polidori ◽  
Domenick Argenti ◽  
Nicholas A Di Prospero
Keyword(s):  
Type 2 Diabetes ◽  
Pediatric Patients ◽  
Pharmacokinetics And Pharmacodynamics

Prediction of Pharmacokinetics and Pharmacodynamics of Doripenem in Pediatric Patients

2015 ◽  
Vol 104 (9) ◽  
pp. 3194-3198 ◽  
Author(s):  
Yumiko Matsuo ◽  
Toru Ishibashi ◽  
Kenji Shimamura ◽  
Toshihiro Wajima
Keyword(s):  
Pediatric Patients ◽  
Pharmacokinetics And Pharmacodynamics
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