Regulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides

2016 ◽  
pp. 123-133 ◽  
Author(s):  
Bryan VanSchouwen ◽  
Giuseppe Melacini
Keyword(s):  
Ion Channels ◽  
Cyclic Nucleotides

scholarly journals Fluorophore‐Labeled Cyclic Nucleotides as Potent Agonists of Cyclic Nucleotide‐Regulated Ion Channels

ChemBioChem ◽  
2020 ◽  
Vol 21 (16) ◽  
pp. 2311-2320
Author(s):  
Marco Lelle ◽  
Maik Otte ◽  
Michele Bonus ◽  
Holger Gohlke ◽  
Klaus Benndorf
Keyword(s):  
Ion Channels ◽  
Cyclic Nucleotides ◽  
Cyclic Nucleotide

scholarly journals Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides

2015 ◽  
Vol 291 (1) ◽  
pp. 371-381 ◽  
Author(s):  
Hannah A. DeBerg ◽  
Peter S. Brzovic ◽  
Galen E. Flynn ◽  
William N. Zagotta ◽  
Stefan Stoll
Keyword(s):  
Ion Channels ◽  
Cyclic Nucleotides ◽  
Allosteric Regulation

Sensory Receptors

The Neuron ◽  
2015 ◽  
pp. 295-326
Author(s):  
Irwin B. Levitan ◽  
Leonard K. Kaczmarek
Keyword(s):  
Plasma Membrane ◽  
Ion Channels ◽  
Hair Cells ◽  
Cyclic Nucleotides ◽  
Second Messengers ◽  
External Stimulus ◽  
Sensory Cells ◽  
Taste Receptors ◽  
Sensory Receptors ◽  
External Stimuli

Sensory cells have evolved pathways that allow ion channels to be regulated by external stimuli such as movement, light, or chemicals. In some cases, such as in photoreceptors and olfactory and taste receptors, the means by which the external stimulus is transduced is reasonably well understood. Such cells appear to handle information in ways similar to those used by neurons that deal with information coming from a presynaptic pathway, by altering the levels of second messengers such as cyclic nucleotides, which then open or close ion channels in the plasma membrane. In contrast, in mechanoreceptors, which include touch receptors and hair cells of the cochlea that are required for hearing, movement is directly linked to the gating of ion channels.

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