scholarly journals Direct gating of ion channels by cyclic nucleotides in visual and olfactory cells in vertebrates. Physiological functions of cyclic nucleotides in the absense of protein phosphorylation.

1988 ◽  
Vol 28 (3) ◽  
pp. 152-155
Author(s):  
TAKAO SHINOZAWA
Keyword(s):  
Ion Channels ◽  
Protein Phosphorylation ◽  
Cyclic Nucleotides ◽  
Physiological Functions ◽  
Olfactory Cells

scholarly journals Fluorophore‐Labeled Cyclic Nucleotides as Potent Agonists of Cyclic Nucleotide‐Regulated Ion Channels

ChemBioChem ◽  
2020 ◽  
Vol 21 (16) ◽  
pp. 2311-2320
Author(s):  
Marco Lelle ◽  
Maik Otte ◽  
Michele Bonus ◽  
Holger Gohlke ◽  
Klaus Benndorf
Keyword(s):  
Ion Channels ◽  
Cyclic Nucleotides ◽  
Cyclic Nucleotide

scholarly journals Common evolutionary origins of mechanosensitive ion channels in Archaea, Bacteria and cell-walled Eukarya

Archaea ◽  
2002 ◽  
Vol 1 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Anna Kloda ◽  
Boris Martinac
Keyword(s):  
Ion Channels ◽  
Lipid Bilayer ◽  
Sequence Homology ◽  
Eukaryotic Cell ◽  
Physiological Functions ◽  
Ancestral Origin ◽  
Gating Mechanisms ◽  
Evolutionary Origins ◽  
Osmotic Challenge ◽  
Small Conductance

The ubiquity of mechanosensitive (MS) channels triggered a search for their functional homologs in Archaea. Archaeal MS channels were found to share a common ancestral origin with bacterial MS channels of large and small conductance, and sequence homology with several proteins that most likely function as MS ion channels in prokaryotic and eukaryotic cell-walled organisms. Although bacterial and archaeal MS channels differ in conductive and mechanosensitive properties, they share similar gating mechanisms triggered by mechanical force transmitted via the lipid bilayer. In this review, we suggest that MS channels of Archaea can bridge the evolutionary gap between bacterial and eukaryotic MS channels, and that MS channels of Bacteria, Archaea and cell-walled Eukarya may serve similar physiological functions and may have evolved to protect the fragile cellular membranes in these organisms from excessive dilation and rupture upon osmotic challenge.

scholarly journals ACTH, cyclic nucleotides, and brain protein phosphorylation in vitro

1976 ◽  
Vol 1 (6) ◽  
pp. 669-677 ◽  
Author(s):  
H. Zwiers ◽  
H. D. Veldhuis ◽  
P. Schotman ◽  
W. H. Gispen
Keyword(s):  
Protein Phosphorylation ◽  
Cyclic Nucleotides ◽  
Brain Protein
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