Electrospinning of Biocompatible Polymers and Their Potentials in Biomedical Applications

2011 ◽  
pp. 213-239 ◽  
Author(s):  
Pitt Supaphol ◽  
Orawan Suwantong ◽  
Pakakrong Sangsanoh ◽  
Sowmya Srinivasan ◽  
Rangasamy Jayakumar ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Biocompatible Polymers

Biocompatible Polymers and their Potential Biomedical Applications: A Review

2019 ◽  
Vol 25 (34) ◽  
pp. 3608-3619 ◽  
Author(s):  
Uzma Arif ◽  
Sajjad Haider ◽  
Adnan Haider ◽  
Naeem Khan ◽  
Abdulaziz A. Alghyamah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Biomedical Applications ◽  
Living System ◽  
Health Condition ◽  
The Body ◽  
Biocompatible Polymers ◽  
Nano Technology ◽  
Artificial Grafts ◽  
Immunological Reactions

Background: Biocompatible polymers are gaining great interest in the field of biomedical applications. The term biocompatibility refers to the suitability of a polymer to body and body fluids exposure. Biocompatible polymers are both synthetic (man-made) and natural and aid in the close vicinity of a living system or work in intimacy with living cells. These are used to gauge, treat, boost, or substitute any tissue, organ or function of the body. A biocompatible polymer improves body functions without altering its normal functioning and triggering allergies or other side effects. It encompasses advances in tissue culture, tissue scaffolds, implantation, artificial grafts, wound fabrication, controlled drug delivery, bone filler material, etc. Objectives: This review provides an insight into the remarkable contribution made by some well-known biopolymers such as polylactic-co-glycolic acid, poly(ε-caprolactone) (PCL), polyLactic Acid, poly(3- hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), Chitosan and Cellulose in the therapeutic measure for many biomedical applications. Methods: : Various techniques and methods have made biopolymers more significant in the biomedical fields such as augmentation (replaced petroleum based polymers), film processing, injection modeling, blow molding techniques, controlled / implantable drug delivery devices, biological grafting, nano technology, tissue engineering etc. Results: The fore mentioned techniques and other advanced techniques have resulted in improved biocompatibility, nontoxicity, renewability, mild processing conditions, health condition, reduced immunological reactions and minimized side effects that would occur if synthetic polymers are used in a host cell. Conclusion: Biopolymers have brought effective and attainable targets in pharmaceutics and therapeutics. There are huge numbers of biopolymers reported in the literature that has been used effectively and extensively.

scholarly journals Chemistry Routes for Copolymer Synthesis Containing PEG for Targeting, Imaging, and Drug Delivery Purposes

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 327 ◽  
Author(s):  
Kamil Rahme ◽  
Nazih Dagher
Keyword(s):  
Biomedical Applications ◽  
Near Infrared ◽  
Blood Stream ◽  
Biocompatible Polymers ◽  
Low Molecular Weight ◽  
Blood Components ◽  
Vast Number ◽  
Macrophage Phagocytosis ◽  
Sterical Hindrance

Polyethylene glycol (PEG) is one of the most frequently used polymers for coating nanocarriers to enhance their biocompatibility, hydrophilicity, stability, and biodegradability. PEG is now considered to be among the best biocompatible polymers. It offers sterical hindrance against other nanoparticles and blood components such as opsonin, preventing their macrophage phagocytosis and resulting in a prolonged circulation time in blood stream, consequently a ‘stealth character’ in vivo. Therefore, PEG has a very promising future for the development of current therapeutics and biomedical applications. Moreover, the vast number of molecules that PEG can conjugate with might enhance its ability to have an optimistic perspective for the future. This review will present an update on the chemistry used in the modern conjugation methods for a variety of PEG conjugates, such methods include, but are not limited to, the synthesis of targeting PEG conjugates (i.e., Peptides, Folate, Biotin, Mannose etc.), imaging PEG conjugates (i.e., Coumarin, Near Infrared dyes etc.) and delivery PEG conjugates (i.e., doxorubicin, paclitaxel, and other hydrophobic low molecular weight drugs). Furthermore, the type of nanoparticles carrying those conjugates, along with their biomedical uses, will be briefly discussed.

Nanofibres and their Influence on Cells for Tissue Regeneration

2005 ◽  
Vol 58 (10) ◽  
pp. 704 ◽  
Author(s):  
Yanping Karen Wang ◽  
Thomas Yong ◽  
Seeram Ramakrishna
Keyword(s):  
Phase Separation ◽  
Cell Growth ◽  
Tissue Regeneration ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Synthetic Polymer ◽  
Biocompatible Polymers ◽  
Mechanical Methods ◽  
The Matrix ◽  
Cell Growth And Proliferation

Synthetic polymer and biopolymer nanofibres can be fabricated through self-assembly, phase separation, electrospinning, and mechanical methods. These novel functional biocompatible polymers are very promising for a variety of future biomedical applications. There are many characteristics of nanofibres that would potentially influence cell growth and proliferation. As such, many studies have been carried out to elucidate the cell–nanofibre interaction with the purpose of optimizing the matrix for cell growth and tissue regeneration. In this Review, we present current literatures and our research on the interactions between cells and nanofibres, and the potentials of nanofibre scaffolds for biomedical applications.

scholarly journals Poly(vinyl alcohol): Physical Approaches to Designing Biomaterials for Biomedical Applications

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Shathani Nkhwa ◽  
Kristo Fernando Lauriaga ◽  
Evren Kemal ◽  
Sanjukta Deb
Keyword(s):  
Vinyl Alcohol ◽  
Biomedical Applications ◽  
Physical And Mechanical Properties ◽  
Poly Vinyl Alcohol ◽  
Biocompatible Polymers ◽  
Chemical Crosslinking ◽  
Biocompatible Polymer ◽  
Physical Methods ◽  
Physically Crosslinked ◽  
Physical Crosslinking

Poly(vinyl alcohol) is a non-toxic, biosynthetic polymer and biocompatible polymer that has the ability to form hydrogels either via chemical or physical crosslinking. Whilst chemical crosslinking provides greater control on the properties of the resultant hydrogel, physically crosslinked hydrogels or blends with other biocompatible polymers are more suited for biomedical applications. In this paper we report a systematic study on the effect of varying concentrations of PVA, physical methods of crosslinking, and PVA-gelatin and PVA-PVP blends on the physical and mechanical properties of the hydrogels.

scholarly journals Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 486 ◽  
Author(s):  
Amalia Mira ◽  
Carlos Sainz-Urruela ◽  
Helena Codina ◽  
Stuart I. Jenkins ◽  
Juan Carlos Rodriguez-Diaz ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Chemical Structure ◽  
Nanoparticle Synthesis ◽  
Chemical Properties ◽  
Biocompatible Polymers ◽  
Therapeutic Drug ◽  
Methyl Vinyl ◽  
Solvent Displacement ◽  
Methyl Vinyl Ether ◽  
Derivatives Of

Recent advances in the field of nanotechnology such as nanoencapsulation offer new biomedical applications, potentially increasing the scope and efficacy of therapeutic drug delivery. In addition, the discovery and development of novel biocompatible polymers increases the versatility of these encapsulating nanostructures, enabling chemical properties of the cargo and vehicle to be adapted to specific physiological requirements. Here, we evaluate the capacity of various polymeric nanostructures to encapsulate various antibiotics of different classes, with differing chemical structure. Polymers were sourced from two separate derivatives of poly(methyl vinyl ether-alt-maleic anhydride) (PMVE/MA): an acid (PMVE/MA-Ac) and a monoethyl ester (PMVE/MA-Es). Nanoencapsulation of antibiotics was attempted through electrospinning, and nanoparticle synthesis through solvent displacement, for both polymers. Solvent incompatibilities prevented the nanoencapsulation of amikacin, neomycin and ciprofloxacin in PMVE/MA-Es nanofibers. However, all compounds were successfully loaded into PMVE/MA-Es nanoparticles. Encapsulation efficiencies in nanofibers reached approximately 100% in all compatible systems; however, efficiencies varied substantially in nanoparticles systems, depending on the tested compound (14%–69%). Finally, it was confirmed that both these encapsulation processes did not alter the antimicrobial activity of any tested antibiotic against Staphylococcus aureus and Escherichia coli, supporting the viability of these approaches for nanoscale delivery of antibiotics.

Potential of Cell Surface Engineering with Biocompatible Polymers for Biomedical Applications

Langmuir ◽  
2020 ◽  
Vol 36 (41) ◽  
pp. 12088-12106 ◽  
Author(s):  
Yuji Teramura ◽  
Kristina Nilsson Ekdahl ◽  
Karin Fromell ◽  
Bo Nilsson ◽  
Kazuhiko Ishihara
Keyword(s):  
Cell Surface ◽  
Biomedical Applications ◽  
Surface Engineering ◽  
Biocompatible Polymers ◽  
Cell Surface Engineering

Preparation and characterization of bioactive and breathable polyvinyl alcohol nanowebs using a combinational approach

TAPPI Journal ◽  
2016 ◽  
Vol 15 (10) ◽  
pp. 655-662 ◽  
Author(s):  
UDAY TURAGA ◽  
VINITKUMAR SINGH ◽  
ANNA GIBSON ◽  
SHAHRIMA MAHARUBIN ◽  
CAROL KORZENIEWSKI ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Antimicrobial Properties ◽  
Vapor Transport ◽  
Biocompatible Polymers ◽  
Textile Materials ◽  
Moisture Vapor ◽  
Materials Used

Electrospun polyvinyl alcohol (PVA) nanowebs treated with a mixture of honey and polyhexamethylene biguanides (PHMBs, commercially available as Reputex 20) were prepared and characterized to evaluate their applicability in wound dressing applications. Fourier transform infrared spectroscopy was used to confirm the incorporation of functional moieties from honey and Reputex 20 into electrospun PVA nanowebs. Functionalized PVA nanowebs were characterized by evaluating their antimicrobial properties, moisture vapor transport characteristics (breathability), and tensile properties. PVA nanowebs treated with a mixture of honey and PHMBs have shown good antimicrobial activity. Additionally, functionalized PVA nanowebs have shown adequate breathability characteristics, a much needed attribute in textile materials used in wound dressing applications. Nanowebs fabricated from biocompatible polymers such as PVA, and functionalized in a combinational fashion, could be used in many different biomedical applications, including wound healing bandages and cell or tissue culture scaffolds.

Functionalized Antimicrobial Electrospun Poly (vinyl alcohol) Nanowebs

2016 ◽  
Vol 11 (2) ◽  
pp. 155892501601100 ◽  
Author(s):  
Uday Turaga ◽  
Vinitkumar Singh ◽  
Anna Gibson ◽  
Shahrima Maharubin ◽  
Carol Korzeniewski ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Vinyl Alcohol ◽  
Biomedical Applications ◽  
Antimicrobial Properties ◽  
Poly Vinyl Alcohol ◽  
Biocompatible Polymers ◽  
Gram Negative Bacteria ◽  
Gram Negative

Electrospun poly (vinyl alcohol) [PVA] nanowebs functionalized with a commercially available microbiocidal solution Reputex™ 20 were prepared. The active ingredient of Reputex™ 20 is polyhexamethylene biguanides, a safe antiseptic. Fourier Transform Infrared spectroscopy confirmed the functionalization of PVA nanowebs. Functionalized nanowebs were characterized by evaluating their antimicrobial properties, breathability characteristics and tensile properties. Functionalized nanowebs demonstrated significant antimicrobial activity against both Gram positive and Gram negative bacteria. Nanowebs developed from biocompatible polymers like PVA, and functionalized with safe antiseptics, could find many biomedical applications such as wound bandages.

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