scholarly journals Ultrasound Probe Tracking for Real-Time Ultrasound/MRI Overlay and Visualization of Brain Shift

Author(s):  
David G. Gobbi ◽  
Roch M. Comeau ◽  
Terry M. Peters
Neurosurgery ◽  
2019 ◽  
Vol 66 (Supplement_1) ◽  
Author(s):  
Steve Sungwon Cho ◽  
Ashwin G Ramayya ◽  
Clare W Teng ◽  
Steven Brem ◽  
Sunil Singhal ◽  
...  

Abstract INTRODUCTION Neuronavigation allows neurosurgeons to localize intracranial structures in 3D space and has been shown to have positive impacts on patient survival in neuro-oncology surgery. However, its major limitation is the intraoperative brain-shift phenomenon, in which the brain moves during surgery due to physical, surgical, and/or biological factors, invalidating the preoperative registration and leading to inaccuracies in the cranium. One reliable way to account for brain-shift intraoperatively may be to use tumor-targeting near-infrared fluorophores, such as ICG accumulating in neoplastic tissue (ie, Second-Window ICG), which offers real-time visualization of tumors through normal cortex and dura. METHODS Patients undergoing craniotomy for primary resection of intracranial tumors were enrolled under an ongoing clinical trial investigating the efficacy of SWIG. For this analysis, retrospective data were collected on patients in whom neuronavigation was used to plan the craniotomy in such a way as to place the tumor in the center of the craniotomy (ie, parasagittal tumors, skull-base tumors, and large/asymmetrical tumors were excluded). During surgery, near-infrared imaging was performed before and after durotomy to localize the gross tumor. Image analysis was performed to measure the deviation between the craniotomy center and the center of the tumor as seen with near-infrared fluorescence. RESULTS A total of 63 patients (24 high-grade-gliomas, 12 meningiomas, 25 metastases, 2 others) were included in this preliminary analysis. Neuronavigation demonstrated a median deviation of 22.4% (range 7.7%-44.4%) relative to craniotomy size. Patient position was a significant predictor of neuronavigation inaccuracy, with the prone position having significantly higher inaccuracy (28.5 ± 8.8%) compared to the supine (19.3 ± 9.2%, P-value = .015) or the lateral (17.9 ± 6.6%, P-value = .012) positions. Additionally, the neuronavigation device used and postgraduate training level of the residents performing the registration trended towards significance on multivariate analysis. In contrast, near-infrared fluorescence perfectly delineated the tumor in all cases. CONCLUSION We demonstrate that near-infrared fluorescence imaging offers more accurate localization of intracranial tumors compared to frameless neuronavigation. Near-infrared imaging could potentially be used to adjust neuronavigation registrations intraoperatively to enhance accuracy. Further prospective studies with distance measurements could better explore this potential benefit of intraoperative near-infrared imaging.


2020 ◽  
Author(s):  
Heiying Jin ◽  
Chunxia Zhang

AbstractObjectiveTo describe a new dynamic echodefecography(EDF) using BK ultrasound 8838 transducer and compare its testing results with X-ray defecography.MethodThe BK 8838 ultrasound probe is used to evaluate the static 3D scan, dynamic 3D scan and dynamic 2D scan of pelvic floor and compare its testing results with X-ray defecography and defined its value to evaluate the pelvic floor disease.ResultsFifty-seven patients were studied (24 male and 33 female). Forty seven patients were diagnosed as anismus by EDF and 46 patients were diagnosed as anismus by X-ray defecography. Sixteen patients were diagnosed as rectocele by X-ray defecography, among which eight were classified as mild(6-15mm), 4 as moderate(16-30mm) and 4 as severe(over 30mm).Fourteen patients with constipation and 2 patients with anal pain were diagnosed as intussusception by EDF, but only 3 patients were diagnosed as intussusception by X-ray defecography. Two patients with constipation were diagnosed as perineal descent by EDF and none by X-ray defecography. Two patients were diagnosed as enterocele by EDF as well as X-ray defecography.ConclusionThe EDF established by BK 8838 ultrasound probe can show clear anatomy and real time movement of pelvic floor muscle. The EDF is more sensitive to the diagnosis of intussusception, perineal descent(PD) and anal spincter defect than X-ray defecograpgy. For anismus,rectocele and enterocele,the diagnosis results are comparable between EDF and X ray defecography. Further study is needed to determine its clinical values to evaluate the pelvic disease.


2021 ◽  
Author(s):  
Parastoo Farnia ◽  
Bahador Makkiabadi ◽  
Meysam Alimohammadi ◽  
Ebrahim Najafzadeh ◽  
Maryam Basij ◽  
...  

Brain shift is an important obstacle for the application of image guidance during neurosurgical interventions. There has been a growing interest in intra-operative imaging systems to update the image-guided surgery systems with real-time data. However, due to the innate limitations of the current imaging modalities, accurate and real-time brain shift compensation remains as a challenging problem. In this study, application of the intra-operative photoacoustic (PA) imaging and registration of the intra-operative PA images with pre-operative brain MR images is proposed to compensate brain deformation during surgery. Finding a satisfactory multimodal image registration method is a challenging problem due to complicated and unpredictable nature of brain deformation. In this study, the co-sparse analysis model is proposed for PA-MR image registration which can capture the interdependency of two modalities. The proposed algorithm works based on the minimization of mapping transform by using a pair of analysis operators. These operators are learned by the alternating direction method of multipliers. The method was evaluated using experimental phantom and ex-vivo data obtained from mouse brain. The results of phantom data show about 60% and 63% improvement in root mean square error (RMSE) and target registration error (TRE) in comparison with commonly used normalized mutual information registration method. In addition, the results of mouse brain and phantom data shown more accurate performance for PA versus ultrasound imaging for brain shift calculation. Finally, by using the proposed registration method, the intra-operative PA images could become a promising tool when the brain shift invalidated pre-operative MRI.


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