2.7.2.2 Purines and pyrimidines

2005 ◽  
pp. 284-297
Author(s):  
G. A. Jeffrey
Keyword(s):  
Purines And Pyrimidines

Purines and Pyrimidines: Metabolism, Function and Potential as therapeutic options in neurodegenerative diseases

2020 ◽  
Vol 21 ◽  
Author(s):  
Debanjan Kundu ◽  
Vikash Kumar Dubey
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurodegenerative Disorders ◽  
Protein Misfolding ◽  
Molecular Mechanisms ◽  
Treatment Regimens ◽  
Loss Of Balance ◽  
Current Scenario ◽  
Unexplored Area ◽  
Molecular Origin ◽  
Purines And Pyrimidines

Abstract:: Various neurodegenerative disorders have molecular origin but some common molecular mechanisms. In the current scenario, there are very few treatment regimens present for advanced neurodegenerative diseases. In this context, there is an urgent need for alternate options in the form of natural compounds with an ameliorating effect on patients. There have been individual scattered experiments trying to identify potential values of various intracellular metabolites. Purines and Pyrimidines, which are vital molecules governing various aspects of cellular biochemical reactions, have been long sought as crucial candidates for the same, but there are still many questions that go unanswered. Some critical functions of these molecules associated with neuromodulation activities have been identified. They are also known to play a role in foetal neurodevelopment, but there is a lacuna in understanding their mechanisms. In this review, we have tried to assemble and identify the importance of purines and pyrimidines, connecting them with the prevalence of neurodegenerative diseases. The leading cause of this class of diseases is protein misfolding and the formation of amyloids. A direct correlation between loss of balance in cellular homeostasis and amyloidosis is yet an unexplored area. This review aims at bringing the current literature available under one umbrella serving as a foundation for further extensive research in this field of drug development in neurodegenerative diseases.

The utilization of purines and pyrimidines by yeasts

1968 ◽  
Vol 14 (1) ◽  
pp. 79-86 ◽  
Author(s):  
T. A. LaRue ◽  
J. F. T. Spencer
Keyword(s):  
Nitrogen Sources ◽  
Purines And Pyrimidines

Purines and pyrimidines were tested singly as sole nitrogen sources for 123 species of yeast. The utilization of thymine was confined almost exclusively to the Lipomyces and Sporobolomyces. The utilization of purines and pyrimidines by Saccharomyces with reniform spores did not differ from that of other Saccharomyces species.

Effect of pH on polarity of purines and pyrimidines

1968 ◽  
Vol 22 (2) ◽  
pp. 345-348 ◽  
Author(s):  
C.E. Hedrick ◽  
Gary McDougall
Keyword(s):  
Effect Of Ph ◽  
Purines And Pyrimidines

All valence-electrons calculations on purines and pyrimidines

1968 ◽  
Vol 10 (3) ◽  
pp. 231-239 ◽  
Author(s):  
A. Pullman ◽  
E. Kochanski ◽  
M. Gilbert ◽  
A. Denis
Keyword(s):  
Valence Electrons ◽  
Purines And Pyrimidines

Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines

1997 ◽  
Vol 62 (9) ◽  
pp. 2861-2871 ◽  
Author(s):  
Yuris Maurinsh ◽  
Jan Schraml ◽  
Hans De Winter ◽  
Norbert Blaton ◽  
Oswald Peeters ◽  
...  
Keyword(s):  
Conformational Study ◽  
Purines And Pyrimidines
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