scholarly journals Bovine Herpesvirus 1 Glycoprotein G Is Required for Prevention of Apoptosis and Efficient Viral Growth in Rabbit Kidney Cells

Virology ◽  
2001 ◽  
Vol 279 (2) ◽  
pp. 488-498 ◽  
Author(s):  
Kazuo Nakamichi ◽  
Daisuke Kuroki ◽  
Yasunobu Matsumoto ◽  
Haruki Otsuka
Keyword(s):  
Bovine Herpesvirus ◽  
Rabbit Kidney ◽  
Kidney Cells ◽  
Bovine Herpesvirus 1 ◽  
Viral Growth ◽  
Glycoprotein G ◽  
Herpesvirus 1

Bovine herpesvirus 1 glycoprotein G is required for viral growth by cell-to-cell infection

2000 ◽  
Vol 68 (2) ◽  
pp. 175-181 ◽  
Author(s):  
Kazuo Nakamichi ◽  
Kentaro Ohara ◽  
Daisuke Kuroki ◽  
Haruki Otsuka
Keyword(s):  
Bovine Herpesvirus ◽  
Cell Infection ◽  
Bovine Herpesvirus 1 ◽  
Viral Growth ◽  
Glycoprotein G ◽  
Herpesvirus 1

scholarly journals The Multiple Chemokine-Binding Bovine Herpesvirus 1 Glycoprotein G (BHV1gG) Inhibits Polymorphonuclear Cell but Not Monocyte Migration into Inflammatory Sites

2013 ◽  
Vol 19 (1) ◽  
pp. 276-285 ◽  
Author(s):  
Zheng Liu ◽  
Ramalingam Bethunaickan ◽  
Ranjit Sahu ◽  
Max Brenner ◽  
Teresina Laragione ◽  
...  
Keyword(s):  
Bovine Herpesvirus ◽  
Polymorphonuclear Cell ◽  
Bovine Herpesvirus 1 ◽  
Monocyte Migration ◽  
Glycoprotein G ◽  
Herpesvirus 1

scholarly journals The Class II Membrane Glycoprotein G of Bovine Respiratory Syncytial Virus, Expressed from a Synthetic Open Reading Frame, Is Incorporated into Virions of Recombinant Bovine Herpesvirus 1

1998 ◽  
Vol 72 (5) ◽  
pp. 3804-3811 ◽  
Author(s):  
Gisela Kühnle ◽  
Astrid Heinze ◽  
Jutta Schmitt ◽  
Katrin Giesow ◽  
Geraldine Taylor ◽  
...  
Keyword(s):  
Bovine Herpesvirus ◽  
Class Ii ◽  
Open Reading Frame ◽  
Membrane Glycoprotein ◽  
Bovine Herpesvirus 1 ◽  
Reading Frame ◽  
Glycoprotein G ◽  
Infected Cells ◽  
Herpesvirus 1 ◽  
Syncytial Virus

ABSTRACT The bovine herpesvirus 1 (BHV-1) recombinants BHV-1/eGori and BHV-1/eGsyn were isolated after insertion of expression cassettes which contained either a genomic RNA-derived cDNA fragment (BHV-1/eGori) or a modified, chemically synthesized open reading frame (ORF) (BHV-1/eGsyn), which both encode the attachment glycoprotein G of bovine respiratory syncytial virus (BRSV), a class II membrane glycoprotein. Northern blot analyses and nuclear runoff transcription experiments indicated that transcripts encompassing the authentic BRSV G ORF were unstable in the nucleus of BHV-1/eGori-infected cells. In contrast, high levels of BRSV G RNA were detected in BHV-1/eGsyn-infected cells. Immunoblots showed that the BHV-1/eGsyn-expressed BRSV G glycoprotein contains N- and O-linked carbohydrates and that it is incorporated into the membrane of infected cells and into the envelope of BHV-1/eGsyn virions. The latter was also demonstrated by neutralization of BHV-1/eGsyn infectivity by monoclonal antibodies or polyclonal anti-BRSV G antisera and complement. Our results show that expression of the BRSV G glycoprotein by BHV-1 was dependent on the modification of the BRSV G ORF and indicate that incorporation of class II membrane glycoproteins into BHV-1 virions does not necessarily require BHV-1-specific signals. This raises the possibility of targeting heterologous polypeptides to the viral envelope, which might enable the construction of BHV-1 recombinants with new biological properties and the development of improved BHV-1-based live and inactivated vector vaccines.

scholarly journals A bovine herpesvirus 1 pUL51 deletion mutant shows impaired viral growth in vitro and reduced virulence in rabbits

Oncotarget ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 12235-12253 ◽  
Author(s):  
Sohail Raza ◽  
Mingliang Deng ◽  
Farzana Shahin ◽  
Kui Yang ◽  
Changmin Hu ◽  
...  
Keyword(s):  
Deletion Mutant ◽  
Bovine Herpesvirus ◽  
Bovine Herpesvirus 1 ◽  
Viral Growth ◽  
Herpesvirus 1
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