Roles of Oxidative Stress and Glutathione Depletion in JP-8 Jet Fuel-Induced Apoptosis in Rat Lung Epithelial Cells

2002 ◽  
Vol 180 (2) ◽  
pp. 92-99 ◽  
Author(s):  
A.Hamid Boulares ◽  
Francisco J. Contreras ◽  
Luis A. Espinoza ◽  
Mark E. Smulson
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Jet Fuel ◽  
Lung Epithelial Cells ◽  
Glutathione Depletion ◽  
Rat Lung ◽  
Lung Epithelial ◽  
Induced Apoptosis

Characterization of cadmium-induced apoptosis in rat lung epithelial cells: evidence for the participation of oxidant stress

Toxicology ◽  
1999 ◽  
Vol 133 (1) ◽  
pp. 43-58 ◽  
Author(s):  
B.A. Hart ◽  
C.H. Lee ◽  
G.S. Shukla ◽  
A. Shukla ◽  
M. Osier ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Oxidant Stress ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Lung Epithelial ◽  
Induced Apoptosis

A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference

2010 ◽  
Vol 24 (1) ◽  
pp. 310-318 ◽  
Author(s):  
William E. Wixted ◽  
Chris Kitson ◽  
Jayne C. Colebrook ◽  
Emma J. Roberts ◽  
Steven M. Fox ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rna Interference ◽  
Epithelial Cells ◽  
Human Lung ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Novel Targets ◽  
Induced Apoptosis ◽  
Human Lung Epithelial Cells

scholarly journals Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells

2004 ◽  
Vol 5 (1) ◽  
pp. 11 ◽  
Author(s):  
Jin Hyuk Choi ◽  
Jun Sung Kim ◽  
Young Chul Kim ◽  
Yoon Shin Kim ◽  
Nam Hyun Chung ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Comparative Study ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Lung Epithelial ◽  
Pm2.5 And Pm10

Mechanisms of JP-8 Jet Fuel Toxicity. I. Induction of Apoptosis in Rat Lung Epithelial Cells

2001 ◽  
Vol 171 (2) ◽  
pp. 94-106 ◽  
Author(s):  
Bogdan A. Stoica ◽  
A.Hamid Boulares ◽  
Dean S. Rosenthal ◽  
Sudha Iyer ◽  
Ivan D.G. Hamilton ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Jet Fuel ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Lung Epithelial ◽  
Induction Of Apoptosis

Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas/FasL pathway

2006 ◽  
Vol 290 (4) ◽  
pp. L790-L796 ◽  
Author(s):  
Shulamit B. Wallach-Dayan ◽  
Gabriel Izbicki ◽  
Pazit Y. Cohen ◽  
Regina Gerstl-Golan ◽  
Alan Fine ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Lung Epithelial Cells ◽  
Mouse Lung ◽  
Caspase 8 ◽  
Caspase 9 ◽  
Lung Epithelial ◽  
Induced Apoptosis

Epithelial cells are considered to be a main target of bleomycin-induced lung injury, which leads to fibrosis in vivo. We studied the characteristics of in vitro bleomycin-induced apoptosis in a mouse lung epithelial (MLE) cell line. Bleomycin caused an increase of reactive oxygen species (ROS) resulting in oxidative stress, mitochondrial leakage, and apoptosis. These were associated with elevated caspase-8 and resultant caspase-9 activity and with upregulation of Fas expression. Glutathione and inhibitors of caspase-8 or caspase-9, but not of FasL, inhibited these effects, suggesting their dependence on ROS, caspase-8 and -9, in a Fas/FasL-independent pathway. However, postbleomycin-exposed MLE cells were more sensitive to Fas-mediated apoptosis. These results demonstrate that the initial bleomycin-induced oxidative stress causes a direct apoptotic effect in lung epithelial cells involving a regulatory role of caspase-8 on caspase-9. Fas represents an amplification mechanism, and not a direct trigger of bleomycin-induced epithelial cell apoptosis.

scholarly journals Single-Walled Carbon Nanotubes Induces Oxidative Stress in Rat Lung Epithelial Cells

2007 ◽  
Vol 7 (7) ◽  
pp. 2466-2472 ◽  
Author(s):  
Chidananda S. Sharma ◽  
Shubhashish Sarkar ◽  
Adaikkappan Periyakaruppan ◽  
Johnny Barr ◽  
Kimberly Wise ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carbon Nanotubes ◽  
Epithelial Cells ◽  
Single Walled Carbon Nanotubes ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Single Walled Carbon ◽  
Lung Epithelial ◽  
Walled Carbon Nanotubes
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