Mechanisms of JP-8 Jet Fuel Toxicity. I. Induction of Apoptosis in Rat Lung Epithelial Cells

2001 ◽  
Vol 171 (2) ◽  
pp. 94-106 ◽  
Author(s):  
Bogdan A. Stoica ◽  
A.Hamid Boulares ◽  
Dean S. Rosenthal ◽  
Sudha Iyer ◽  
Ivan D.G. Hamilton ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Jet Fuel ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Lung Epithelial ◽  
Induction Of Apoptosis

Induction of apoptosis in rat lung epithelial cells by multiwalled carbon nanotubes

2009 ◽  
Vol 23 (5) ◽  
pp. 333-344 ◽  
Author(s):  
Prabakaran Ravichandran ◽  
Adaikkappan Periyakaruppan ◽  
Bindu Sadanandan ◽  
Vani Ramesh ◽  
Joseph C. Hall ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Epithelial Cells ◽  
Multiwalled Carbon Nanotubes ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Multiwalled Carbon ◽  
Lung Epithelial ◽  
Induction Of Apoptosis

Induction of Apoptosis in Rat Lung Epithelial Cells by Multiwalled Carbon Nanotubes

2013 ◽  
Vol 27 (5) ◽  
pp. 286-286 ◽  
Author(s):  
Prabakaran Ravichandran ◽  
Adaikkappan Periyakaruppan ◽  
Bindu Sadanandan ◽  
Vani Ramesh ◽  
Joseph C. Hall ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Epithelial Cells ◽  
Multiwalled Carbon Nanotubes ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Multiwalled Carbon ◽  
Lung Epithelial ◽  
Induction Of Apoptosis

Ultrafine carbon particles induce apoptosis and proliferation in rat lung epithelial cells via specific signaling pathways both using EGF-R

2006 ◽  
Vol 291 (4) ◽  
pp. L725-L733 ◽  
Author(s):  
Ulrich Sydlik ◽  
Katrin Bierhals ◽  
Maria Soufi ◽  
Josef Abel ◽  
Roel P. F. Schins ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Signaling Pathways ◽  
Ultrafine Particles ◽  
Membrane Receptors ◽  
Lung Epithelial Cells ◽  
Signaling Cascades ◽  
Rat Lung ◽  
End Points ◽  
Lung Epithelial ◽  
Induction Of Apoptosis

Apoptosis and proliferation are important causes of adverse health effects induced by inhaled ultrafine particles. The molecular mechanisms of particle cell interactions mediating these end points are therefore a major topic of current particle toxicology and molecular preventive medicine. Initial studies revealed that ultrafine particles induce apoptosis and proliferation in parallel in rat lung epithelial cells, dependent on time and dosage. With these end points, two antagonistic reactions seem to be induced by the same extracellular stimulus. It was therefore investigated whether proliferation is induced directly by the particles or as a compensation of particle-caused cell death. Experimental conditions excluding compensatory proliferation demonstrated that both end points are induced independently by specific signaling pathways. Events eliciting signaling cascades leading to apoptosis and proliferation were studied with specific inhibitors of membrane receptors. Epidermal growth factor receptor (EGF-R) kinase activity was identified as essential for apoptosis as well as for proliferation. As ultrafine particle-induced proliferation alone was dependent on the activation of β1-integrins, these membrane receptors are suggested to mediate the specificity of EGF-R signaling concerning the decision as to whether apoptosis or proliferation is triggered. Accordingly, MAP kinase signaling downstream of EGF-R showed comparable specificity with regard to receptor-dependent induction of apoptosis and proliferation. As key mediators of signaling cascades, the activation of extracellular signal-regulated kinases 1 and 2 proved to be specific for proliferation in a β1-integrin-dependent manner, whereas phosphorylation of c-Jun NH2-terminal kinases 1 and 2 was correlated with the induction of apoptosis.

Characterization of cadmium-induced apoptosis in rat lung epithelial cells: evidence for the participation of oxidant stress

Toxicology ◽  
1999 ◽  
Vol 133 (1) ◽  
pp. 43-58 ◽  
Author(s):  
B.A. Hart ◽  
C.H. Lee ◽  
G.S. Shukla ◽  
A. Shukla ◽  
M. Osier ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Oxidant Stress ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Lung Epithelial ◽  
Induced Apoptosis

Growth of distal fetal rat lung epithelial cells in a defined serum-free medium

1991 ◽  
Vol 27 (8) ◽  
pp. 625-632 ◽  
Author(s):  
D. Jassal ◽  
R. N. N. Han ◽  
I. Caniggia ◽  
M. Post ◽  
A. K. Tanswell
Keyword(s):  
Epithelial Cells ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Serum Free Medium ◽  
Free Medium ◽  
Serum Free ◽  
Fetal Rat ◽  
Lung Epithelial ◽  
Fetal Rat Lung

scholarly journals Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells

2004 ◽  
Vol 5 (1) ◽  
pp. 11 ◽  
Author(s):  
Jin Hyuk Choi ◽  
Jun Sung Kim ◽  
Young Chul Kim ◽  
Yoon Shin Kim ◽  
Nam Hyun Chung ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Comparative Study ◽  
Lung Epithelial Cells ◽  
Rat Lung ◽  
Lung Epithelial ◽  
Pm2.5 And Pm10
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