Diet Restriction Enhances Compensatory Liver Tissue Repair and Survival Following Administration of Lethal Dose of Thioacetamide

1998 ◽  
Vol 150 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Shashi K. Ramaiah ◽  
Madhusudan G. Soni ◽  
Thomas J. Bucci ◽  
Harihara M. Mehendale
Keyword(s):  
Liver Tissue ◽  
Tissue Repair ◽  
Lethal Dose ◽  
Diet Restriction

354 Growth arrest-specific protein 6 (GAS6) promotes liver tissue repair after an acute toxic injury

2006 ◽  
Vol 44 ◽  
pp. S135 ◽  
Author(s):  
F. Lafdil ◽  
V. Deveaux ◽  
M.N. Chobert ◽  
A. Brouillet ◽  
E.S. Zafrani ◽  
...  
Keyword(s):  
Liver Tissue ◽  
Tissue Repair ◽  
Growth Arrest ◽  
Specific Protein ◽  
Toxic Injury ◽  
Acute Toxic

Thromboxane A2 receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment

2012 ◽  
Vol 259 (1) ◽  
pp. 104-114 ◽  
Author(s):  
Tsutomu Minamino ◽  
Yoshiya Ito ◽  
Hirotoki Ohkubo ◽  
Kanako Hosono ◽  
Tatsunori Suzuki ◽  
...  
Keyword(s):  
Liver Tissue ◽  
Tissue Repair ◽  
Thromboxane A2 ◽  
Receptor Signaling ◽  
Thromboxane A2 Receptor ◽  
Macrophage Recruitment ◽  
Toxic Injury

Dose-Dependent Liver Tissue Repair After Chloroform plus Trichloroethylene Binary Mixture

2005 ◽  
Vol 96 (6) ◽  
pp. 436-444 ◽  
Author(s):  
Sathanandam S. Anand ◽  
Moiz M. Mumtaz ◽  
Harihara M. Mehendale
Keyword(s):  
Binary Mixture ◽  
Liver Tissue ◽  
Tissue Repair ◽  
Dose Dependent

Matrix metalloproteinase-10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair

2013 ◽  
Vol 34 (7) ◽  
pp. e257-e270 ◽  
Author(s):  
Oihane Garcia-Irigoyen ◽  
Simone Carotti ◽  
Maria U. Latasa ◽  
Iker Uriarte ◽  
Maite G. Fernández-Barrena ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Liver Tissue ◽  
Tissue Repair ◽  
Hepatic Injury

scholarly journals Evaluation of Median Lethal Dose and Subchronic Oral Toxicity Assessment of Ethanolic Leaf Extract of Phyllanthus amarus

2019 ◽  
pp. 1-8
Author(s):  
O. E. Adolor ◽  
I. Onyesom ◽  
A. O. Opajobi ◽  
J. C. Mordi
Keyword(s):  
Body Weight ◽  
Total Antioxidant Capacity ◽  
Liver Tissue ◽  
Leaf Extract ◽  
Lethal Dose ◽  
Phyllanthus Amarus ◽  
Oral Toxicity ◽  
Weight Group ◽  
Total Antioxidant ◽  
Ethanolic Leaf Extract

Aims: To determine the median lethal dose (LD50) of crude ethanolic leaf extract of Phyllanthus amarus and evaluate its sub-chronic oral toxicity in experimental mice (BALB/C strain). Study Design: One-factor, one-control, one-test group experimental design. Place and Duration of Study: Department of Medical Biochemistry, Delta State University, Abraka, Nigeria, between December, 2014 and November, 2015. Methodology: Crude ethanolic leaf extract of P. amarus was prepared as previously described and twenty (20) Swiss albino mice (BALB/C strain) were randomly and equally divided into two (2) groups and administered 2000 mg/kg body weight (Group A) and 5000 mg/kg body weight (Group B) of the prepared extract as single oral dose in line with the limit dose method of determining LD50. For the sub-chronic oral toxicity study, ten (10) mice were assigned into control (n=5) and experimental (n=5). The control animals were given placebo-normal saline, but the experimental mice were administered with nocebo – 300 mg/kg body weight of P. amarus crude ethanolic extract for twenty one (21) days. Thereafter, the animals in each group were sacrificed and then, serum and liver homogenate were obtained for the assay of total antioxidant capacity (TAC) and oxidative damage (Malondialdehyde-MDA) Using documented methods. Liver tissue was also processed for histopathological examination using H&E stain. Results: Data showed LD50 of the extract to be greater than 5000 mg/kg. Assessment of the herb’s sub-chronic oral toxicity indicates that the leaf extract significantly (P=.03) enhanced total antioxidant capacity (TAC) in both serum (Control: TAC = 0.10±0.03 mM, Experimental: TAC = 0.33±0.05 mM) and liver (Control: TAC = 0.12±0.09 mM, Experimental: TAC = 0.34±0.06 mM) but reduced (P = .01) the biomarker for liver tissue damage (Control: MDA = 41.89±3.36 µM, Experimental: MDA = 4.67±4.04 µM). In addition, hepatic cells were invigorated by P. amarus treatment as suggested by the histopathological features. Conclusion: Collectively, P. amarus crude ethanolic leaf extract possesses high degree of tolerance and hepatic tonic potential with no identifiable toxic or side effects.

Mesenchymal stromal cells isolated from human fetal liver release soluble factors with a potential role in liver tissue repair

2019 ◽  
Vol 105 ◽  
pp. 14-26 ◽  
Author(s):  
Cinzia Maria Chinnici ◽  
Giada Pietrosi ◽  
Gioacchin Iannolo ◽  
Giandomenico Amico ◽  
Nicola Cuscino ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Liver Tissue ◽  
Tissue Repair ◽  
Potential Role ◽  
Fetal Liver ◽  
Soluble Factors ◽  
Human Fetal Liver

Fr399 PROTEOMIC MARKERS OF LIVER TISSUE REPAIR AND REGENERATION ARE DYSREGULATED IN ALCOHOL-ASSOCIATED HEPATITIS

2021 ◽  
Vol 160 (6) ◽  
pp. S-311
Author(s):  
Josiah Hardesty ◽  
Le Zhang ◽  
Jon Jacobs ◽  
Jeffrey Warner ◽  
Dennis Warner ◽  
...  
Keyword(s):  
Liver Tissue ◽  
Tissue Repair ◽  
Tissue Repair And Regeneration
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