NMR Microscopy

Author(s):  
Paul T. Callaghan
Keyword(s):  
Author(s):  
M.J. Hennessy ◽  
E. Kwok

Much progress in nuclear magnetic resonance microscope has been made in the last few years as a result of improved instrumentation and techniques being made available through basic research in magnetic resonance imaging (MRI) technologies for medicine. Nuclear magnetic resonance (NMR) was first observed in the hydrogen nucleus in water by Bloch, Purcell and Pound over 40 years ago. Today, in medicine, virtually all commercial MRI scans are made of water bound in tissue. This is also true for NMR microscopy, which has focussed mainly on biological applications. The reason water is the favored molecule for NMR is because water is,the most abundant molecule in biology. It is also the most NMR sensitive having the largest nuclear magnetic moment and having reasonable room temperature relaxation times (from 10 ms to 3 sec). The contrast seen in magnetic resonance images is due mostly to distribution of water relaxation times in sample which are extremely sensitive to the local environment.


2005 ◽  
Vol 16 (6) ◽  
pp. 511-514 ◽  
Author(s):  
S. C. Grant ◽  
S. Celper ◽  
I. Gauffin-Holmberg ◽  
N. E. Simpson ◽  
S. J. Blackband ◽  
...  
Keyword(s):  

PROTOPLASMA ◽  
1993 ◽  
Vol 173 (3-4) ◽  
pp. 170-176 ◽  
Author(s):  
Y. Xia ◽  
V. Sarafis ◽  
E. O. Campbell ◽  
P. T. Callaghan

1993 ◽  
Vol 11 (2) ◽  
pp. 259-268 ◽  
Author(s):  
M. Gussoni ◽  
F. Greco ◽  
R. Consonni ◽  
H. Molinari ◽  
G. Zannoni ◽  
...  

2012 ◽  
Vol 221 ◽  
pp. 11-18 ◽  
Author(s):  
Stefan Henning ◽  
Daniel Edelhoff ◽  
Benedikt Ernst ◽  
Sabine Leick ◽  
Heinz Rehage ◽  
...  

2006 ◽  
Vol 128 (43) ◽  
pp. 14192-14199 ◽  
Author(s):  
Kirk W. Feindel ◽  
Steven H. Bergens ◽  
Roderick E. Wasylishen

1999 ◽  
Vol 15 (2) ◽  
pp. 99-102 ◽  
Author(s):  
M Szayna ◽  
R Voelkel

ChemPhysChem ◽  
2006 ◽  
Vol 7 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Kirk W. Feindel ◽  
Steven H. Bergens ◽  
Roderick E. Wasylishen

Recent advances in NMR microscopy based on fundamental physical parameters and experimental factors are discussed. We consider fundamental resolution limits due to molecular diffusion and the experimental system bandwidth, as well as practical resolution limits arising from poor signal-to-noise ratio due to small imaging voxel size and finite line broadening due to signal attenuation brought about by diffusion. Several microscopic imaging pulse sequences are presented and applied to elucidating cellular imaging problems such as the cell lineage patterns in Xenopus laevis embryos. Experimental results obtained with 7.0 T NMR microscopy system are presented.


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