Safety Assessment of a Nematode-Resistant Tomato by a Simple, Short-term Rat Feeding Study

1996 ◽  
Vol 24 (1) ◽  
pp. 6-8
Author(s):  
Gilbert S. Stoewsand ◽  
Judy L. Anderson ◽  
Richard W. Robinson
Keyword(s):  
Safety Assessment ◽  
Short Term ◽  
Feeding Study

scholarly journals Safety Assessment of Food and Feed from GM Crops in Europe: Evaluating EFSA’s Alternative Framework for the Rat 90-day Feeding Study

2017 ◽  
Vol 65 (27) ◽  
pp. 5545-5560 ◽  
Author(s):  
Bonnie Hong ◽  
Yingzhou Du ◽  
Pushkor Mukerji ◽  
Jason M. Roper ◽  
Laura M. Appenzeller
Keyword(s):  
Safety Assessment ◽  
Gm Crops ◽  
Alternative Framework ◽  
Feeding Study ◽  
Food And Feed

Safety assessment of food-contact paper and board using a battery of short-term toxicity tests: European union BIOSAFEPAPER project

2005 ◽  
Vol 22 (10) ◽  
pp. 1032-1041 ◽  
Author(s):  
I. Severin ◽  
L. Dahbi ◽  
J. -C. Lhuguenot ◽  
M. A. Andersson ◽  
D. Hoornstra ◽  
...  
Keyword(s):  
European Union ◽  
Safety Assessment ◽  
Toxicity Tests ◽  
Short Term ◽  
Food Contact

Final Report on the Safety Assessment of Aldioxa

1993 ◽  
Vol 12 (3) ◽  
pp. 237-242
Keyword(s):  
Organic Compound ◽  
Guinea Pigs ◽  
Safety Assessment ◽  
Safety Data ◽  
Control Group ◽  
Final Report ◽  
Cosmetic Products ◽  
Feeding Study ◽  
Human Volunteers

Aldioxa is a heterocyclic organic compound used in cosmetic products as an astringent and skin conditioning agent. The oral LD50 for mice exceeds 23 mg/kg, and 8 g/kg for rats. All of the toxicologic parameters investigated in a 94-day subchronic feeding study in rats were similar in the test and the control group. No significant macroscopic adverse results were obtained in a three generation study in which rats were fed diets containing 10% Aldioxa. A suspension containing 25% Aldioxa was not a sensitizer when applied to the shaved backs of 3 male guinea pigs, nor when 10 animals were given intradermal injections of a 2% Aldioxa suspension on alternating days for a total of 10 applications and challenged after a 10-day nontreatment period. A hydrophilic unguent containing 4% Aldioxa was neither an irritant nor a sensitizer when evaluated on 200 human volunteers. The safety of Aldioxa has not been completely documented and substantiated. It cannot be concluded that this ingredient is safe for use in cosmetic products until the appropriate needed safety data cited in the report have been obtained and evaluated.

Final Report on the Safety Assessment of Cyclomethicone

1991 ◽  
Vol 10 (1) ◽  
pp. 9-19 ◽  
Keyword(s):  
Ames Test ◽  
Safety Assessment ◽  
Oral Feeding ◽  
Final Report ◽  
Histopathological Changes ◽  
Short Term ◽  
Local Skin ◽  
Reproductive Effects ◽  
Cosmetic Formulations ◽  
Gross Lesions

Cyclomethicone is a mixture of cyclic dimethylpolysiloxane compounds used primarily as an emollient and solvent in cosmetic formulations at concentrations from <0.1%to>50%. Cyclomethicone is not significantly absorbed through the skin. Small amounts of Cyclomethicone were absorbed by both humans and monkeys in oral feeding studies. The absorbed Cyclomethicone was detected in both the urine and expired air. Acute oral dose of Cyclomethicone to rats produced no deaths nor any gross lesions. Short-term dermal studies produced no behavioral, local skin, gross, nor histopathological changes. In subchronic inhalation studies in monkeys, no significant differences were found between exposed and unexposed animals. Undiluted Cyclomethicone applied to the intact and abraded skin of rabbits produced little or no irritation in two studies. Ocular studies indicated that Cyclomethicone produced only slight transient conjunctival irritation in washed and unwashed eyes. Cyclomethicone did not produce reproductive effects in rats. Cyclomethicone was not a mutagen when assayed in the Ames test. Cyclomethicone was neither irritating nor sensitizing to human skin in two clinical studies. On the basis of the available data, it is concluded that Cyclomethicone is safe as a cosmetic ingredient in present practices of use.

scholarly journals Short-term effects of the DASH diet in adults with moderate chronic kidney disease: a pilot feeding study

2016 ◽  
Vol 9 (4) ◽  
pp. 592-598 ◽  
Author(s):  
Crystal C. Tyson ◽  
Pao-Hwa Lin ◽  
Leonor Corsino ◽  
Bryan C. Batch ◽  
Jenifer Allen ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Short Term ◽  
Dash Diet ◽  
Feeding Study ◽  
Moderate Chronic Kidney Disease ◽  
Short Term Effects

New food from a potato somatic hybrid: nutritional equivalence and safety assessment by a feeding study on rats

2014 ◽  
Vol 95 (9) ◽  
pp. 1911-1917 ◽  
Author(s):  
Oumèma Nouri-Ellouz ◽  
Najiba Zeghal ◽  
Saloua Makni ◽  
Fatma Makni-Ayadi ◽  
Mouhanad Trigui ◽  
...  
Keyword(s):  
Somatic Hybrid ◽  
Safety Assessment ◽  
Feeding Study

scholarly journals The Carbon Isotope Ratio of Breath Is Elevated by Short and Long-Term Added Sugar and Animal Protein Intake in a Controlled Feeding Study

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1069-1069
Author(s):  
Diane O'Brien ◽  
Natasha Tasevska ◽  
Virag Sagi-Kiss ◽  
Susana A Palma-Duran ◽  
Brian Barrett ◽  
...  
Keyword(s):  
Carbon Isotope ◽  
Isotope Ratio ◽  
Carbon Isotope Ratio ◽  
Animal Protein ◽  
Sample Collection ◽  
Short Term ◽  
Added Sugar ◽  
Feeding Study ◽  
Short And Long Term

Abstract Objectives Objective biomarkers would help to clarify relationships between added sugar (AS) intake and chronic disease. A recent study identified the breath carbon isotope ratio (CIR) as a potential short-term AS biomarker. To further evaluate the biomarker potential of the breath CIR, we evaluate the effects of both short and longer-term intakes of AS in the context of normal dietary intake patterns, and also evaluate animal protein (AP), another dietary factor known to influence CIR. Methods We conducted a 15-d controlled feeding study of 100 adults (age 18–70, 55% women) in Phoenix, AZ. Participants were provided individualized diets that approximated habitual food intakes and recorded the time that all foods were consumed throughout each day. Three breath samples were collected on each of 3 nonconsecutive, randomly selected study days: one fasting sample, one “morning” sample (collected 10:00–14:00) and one “evening” sample (collected 14:00–20:00). We used a linear mixed model to evaluate the effects of AS and AP intake in each of 8 hours preceding collection of the breath sample (t1 = 0–1 hour prior, t2 = 1–2 hours prior, etc.). Besides daily intake, models also included 15-d mean AS and AP intake, as well as sex, age and BMI. Coefficients are presented as (β (SE), P). Results Mean (±SD) intakes of AS and AP in our study were 67 ± 34 and 73 ± 30 g/d, respectively. The breath CIR was increased by AS consumed 1–4 hours prior to sample collection (βt2 = 0.014 (0.005), P = 0.0025; βt3 = 0.0094 (0.004), P = 0.02; βt4 = 0.012 (0.005), P = 0.02) and AP consumed 3–6 hours prior to sample collection (βt4 = 0.012 (0.005), P = 0.03; βt5 = 0.0092 (0.004), P = 0.03; βt6 = 0.010 (0.006), P = 0.09). In addition, the breath CIR increased with higher 15-d intakes of both AS and AP (βAS = 0.012 (0.003), P &lt; 0.0001 and βAP = 0.014 (0.004), P = 0.0003, respectively). Conclusions Both short-term and longer-term intakes of AS and AP increased the breath CIR. Short-term AS intake had a more rapid effect on the breath CIR than short-term AP intake, although effects were of similar size. Furthermore, the size of short-term effects were similar to the size of long-term effects. Thus, breath CIR is influenced by both short and long-term intakes of AS and AP and could have potential for evaluating dietary patterns. Funding Sources This work was funded by NIH U01 CA197902.

scholarly journals Safety assessment of genetically modified milk containing human beta-defensin-3 on rats by a 90-day feeding study

2017 ◽  
Vol 100 ◽  
pp. 34-41 ◽  
Author(s):  
Xin Chen ◽  
Ming-Qing Gao ◽  
Dong Liang ◽  
Songna Yin ◽  
Kezhen Yao ◽  
...  
Keyword(s):  
Safety Assessment ◽  
Genetically Modified ◽  
Feeding Study
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