New Evidence for Transmitter Role of VIP in The Airways: Impaired Relaxation by a Catalytic Antibody

2002 ◽  
Vol 15 (2) ◽  
pp. 121-127 ◽  
Author(s):  
H.I. Berisha ◽  
M. Bratut ◽  
Yogesh Bangale ◽  
G. Colasurdo ◽  
S. Paul ◽  
...  
Keyword(s):  
Catalytic Antibody ◽  
New Evidence

New Evidence on the Role of the Media in Corporate Social Responsibility

2016 ◽  
Vol 154 (4) ◽  
pp. 1051-1079 ◽  
Author(s):  
Sadok El Ghoul ◽  
Omrane Guedhami ◽  
Robert Nash ◽  
Ajay Patel
Keyword(s):  
Corporate Social Responsibility ◽  
Social Responsibility ◽  
The Media ◽  
Corporate Social ◽  
New Evidence

Abnormalities of the HPA axis in affective disorders: clinical subtypes and potential treatments

2006 ◽  
Vol 18 (5) ◽  
pp. 193-209 ◽  
Author(s):  
Richard J. Porter ◽  
Peter Gallagher
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairment ◽  
Hpa Axis ◽  
Affective Disorders ◽  
Psychotic Depression ◽  
Review Of The Literature ◽  
Hpa Axis Dysregulation ◽  
New Evidence ◽  
The Brain

Background:New evidence is emerging regarding abnormalities of hypothalamic-pituitary-adrenal (HPA) axis function in subtypes of affective disorders. Adverse effects of HPA axis dysregulation may include dysfunction of monoaminergic transmitter systems, cognitive impairment and peripheral effects. Newer treatments specifically targeting the HPA axis are being developed.Objective:To review these developments focusing particularly on the glucocorticoid receptor (GR) antagonist mifepristone.Method:A selective review of the literature.Results:The function of GRs is increasingly being defined. The role of corticotrophin-releasing hormone (CRH) and dehydroepiandrosterone (DHEA) in the brain is also increasingly understood. HPA axis function is particularly likely to be abnormal in psychotic depression and bipolar disorder, and it is in these conditions that trials of the GR antagonist mifepristone are being focused. CRH antagonists and DHEA are also being investigated as potential treatments.Conclusion:Initial studies of mifepristone and other HPA-axis-targeting agents in psychotic depression and bipolar disorder are encouraging and confirmatory studies are awaited.

Cellular Samurai: katanin and the severing of microtubules

2000 ◽  
Vol 113 (16) ◽  
pp. 2821-2827 ◽  
Author(s):  
L. Quarmby
Keyword(s):  
Epithelial Cells ◽  
Essential Role ◽  
Aaa Atpase ◽  
C Elegans ◽  
Microtubule Severing ◽  
Biochemical Studies ◽  
New Evidence

Recent biochemical studies of the AAA ATPase, katanin, provide a foundation for understanding how microtubules might be severed along their length. These in vitro studies are complemented by a series of recent reports of direct in vivo observation of microtubule breakage, which indicate that the in vitro phenomenon of catalysed microtubule severing is likely to be physiological. There is also new evidence that microtubule severing by katanin is important for the production of non-centrosomal microtubules in cells such as neurons and epithelial cells. Although it has been difficult to establish the role of katanin in mitosis, new genetic evidence indicates that a katanin-like protein, MEI-1, plays an essential role in meiosis in C. elegans. Finally, new proteins involved in the severing of axonemal microtubules have been discovered in the deflagellation system of Chlamydomonas.

The role of systemic corticosteroids in severe asthma and new evidence in their management and tapering

2021 ◽  
Author(s):  
Francesco Menzella ◽  
Giulia Ghidoni ◽  
Matteo Fontana ◽  
Silvia Capobelli ◽  
Francesco Livrieri ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Systemic Corticosteroids ◽  
New Evidence
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