The Nitration Product 5-Nitro-γ-tocopherol Is Increased in the Alzheimer Brain

Nitric Oxide ◽  
2002 ◽  
Vol 6 (2) ◽  
pp. 221-227 ◽  
Author(s):  
Kelly S. Williamson ◽  
S. Prasad Gabbita ◽  
Shenyun Mou ◽  
Melinda West ◽  
Quentin N. Pye ◽  
...  
Keyword(s):  
Alzheimer Brain ◽  
Nitration Product

Synthesis and Tautomerism of Curcumin Derivatives and Related Compounds

2015 ◽  
Vol 68 (2) ◽  
pp. 224 ◽  
Author(s):  
Hiroyasu Taguchi ◽  
Daijiro Yanagisawa ◽  
Shigehiro Morikawa ◽  
Koichi Hirao ◽  
Nobuaki Shirai ◽  
...  
Keyword(s):  
Parent Compound ◽  
Amyloid Plaques ◽  
Enol Form ◽  
19F Nmr ◽  
Enolic Form ◽  
Curcumin Derivatives ◽  
Alkyl Groups ◽  
Alzheimer Brain ◽  
Hydrolysis Of ◽  
Related Compounds

1,7-Bis(4′-hydroxy-3′-trifluoromethoxyphenyl)-1,6-heptadiene-3,5-dione (2a), related to curcumin, and thirteen 4-substituted derivatives were prepared and their keto/enol ratio in DMSO[D6] was determined by 19F NMR because the enolic form of these related curcumins had been shown to bind to amyloid plaques in the Alzheimer brain. The parent compound and the 4-ethoxycarbonyl derivative were almost 100 % in the enolic form that contains a conjugated hepta-1,4,6-trien-3-on-5-ol backbone. Enolisation decreased to varying amounts in the derivatives that had 4-substituted alkyl groups. Attempts to prepare the 4-hydroxypropyl derivative by hydrolysis of O-methoxymethyl 2m or O-tetrahydropyranyloxy 2n protected derivatives led to cyclised products. A related pyrimidine compound 6b that mimicked a fixed enol form was also prepared.

Formation and Structure of a Novel Nitration Product of δ -Tocopherol

2013 ◽  
Vol 10 (1) ◽  
pp. 165-168 ◽  
Author(s):  
Stefan Bohmdorfer ◽  
Anjan Patel ◽  
Lars Gille ◽  
Thomas Netscher ◽  
Kurt Mereiter ◽  
...  
Keyword(s):  
Nitration Product

scholarly journals Structural Confirmation of the Nitration Product of the 1(2H)-Phthalazinone as the 2-Nitro-1(2H)-phthalazinone.

1992 ◽  
Vol 40 (12) ◽  
pp. 3327-3329 ◽  
Author(s):  
Shigeru ITO ◽  
Kentaro YAMAGUCHI ◽  
Yasuo KOMODA
Keyword(s):  
Nitration Product

Medium-sized cyclophanes, part 59:1 Nitration of [3.3]- and [3.3.3]metacyclophanes — Through-space electronic interactions between two or three benzene rings

2002 ◽  
Vol 80 (2) ◽  
pp. 207-215 ◽  
Author(s):  
Takehiko Yamato ◽  
Koji Tsuchihashi ◽  
Noriko Nakamura ◽  
Mai Hirahara ◽  
Hirohisa Tsuzuki
Keyword(s):  
Acetic Anhydride ◽  
Electronic Interaction ◽  
Reaction Conditions ◽  
Tert Butyl ◽  
Mixed Acid ◽  
Butyl Group ◽  
Tert Butyl Group ◽  
Starting Compound ◽  
Nitration Product ◽  
Fuming Nitric Acid

The two tert-butyl groups of anti-6,15-di-tert-butyl-9,18-dimethoxy[3.3]metacyclophane (anti-4) are both ipso-nitrated even under mild reaction conditions such as copper(II) nitrate in an acetic anhydride solution because of the decreased deactivation of the second aromatic ring by the introduced nitro group. On the other hand, anti-5,13-di-tert-butyl-8,16-dimethoxy[2.2]metacyclophane (anti-1) undergoes replacement of only one tert-butyl group under the same reaction conditions. The higher yields of the twofold ipso-nitration product anti-7 were obtained in nitration of anti-4 with fuming nitric acid or mixed acid (HNO3–H2SO4). Thus, the number of ipso-nitrations at the tert-butyl groups of anti-4 was strongly affected by the reactivity of the nitration reagent. Nitration of the corresponding syn-conformer syn-4 with copper(II) nitrate in an acetic anhydride solution, however, led only to the recovery of the starting compound. The presently developed procedure was further applied to the direct removal of the tert-butyl group by electrophilic substitution of the larger-sized ring macrocyclic metacyclophanes, cone- and partial-cone-tri-tert-butyl[3.3.3]metacyclophanes 11.Key words: [3n]metacyclophanes, conformation, ipso-nitration, through-space electronic interaction, crystal structure.

Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain

1986 ◽  
Vol 71 (2) ◽  
pp. 229-234 ◽  
Author(s):  
David M. Armstrong ◽  
Gordon Bruce ◽  
Louis B. Hersh ◽  
Robert D. Terry
Keyword(s):  
Choline Acetyltransferase ◽  
Neuritic Plaques ◽  
Alzheimer Brain

scholarly journals Stereotaxic injection of fibrillar PHF from Alzheimer brain induces propagation of argyrophilic grains constituted of murine tau in mouse brains

2016 ◽  
Vol 8 ◽  
Author(s):  
Houben Sarah ◽  
Audouard Emilie ◽  
Masaracchia Caterina ◽  
Yilmaz Zehra ◽  
Suain Valérie ◽  
...  
Keyword(s):  
Stereotaxic Injection ◽  
Alzheimer Brain ◽  
Argyrophilic Grains

Protease “Clipsin” activity and β-amyloid precursor protein degradation by Alzheimer brain

1993 ◽  
Vol 21 (3) ◽  
pp. 241S-241S
Author(s):  
GARY C. STRATMANN ◽  
MARIE-THERESE WEBSTER ◽  
GURINDER BHOGAL ◽  
PAUL T. FRANCIS ◽  
DAVID M. BOWEN
Keyword(s):  
Amyloid Precursor Protein ◽  
Protein Degradation ◽  
Precursor Protein ◽  
Alzheimer Brain ◽  
Β Amyloid
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