Neurotrophic factor for central cholinergic neurones is present in both normal and Alzheimer brain tissue

1986 ◽  
Vol 69 (3-4) ◽  
pp. 341-342 ◽  
Author(s):  
C. K. Atterwill ◽  
D. M. Bowen
Keyword(s):  
Brain Tissue ◽  
Neurotrophic Factor ◽  
Alzheimer Brain ◽  
Cholinergic Neurones

A mitochondrial DNA deletion in normally aging and in Alzheimer brain tissue

Neuroreport ◽  
1993 ◽  
Vol 4 (6) ◽  
pp. 799-802 ◽  
Author(s):  
Barbara J. Blanchard ◽  
Theresa Park ◽  
William J. Fripp ◽  
Leonard S. Lerman ◽  
Vernon M. Ingram
Keyword(s):  
Mitochondrial Dna ◽  
Brain Tissue ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion ◽  
Alzheimer Brain

scholarly journals Immune System Response in Alzheimer's Disease

1989 ◽  
Vol 16 (S4) ◽  
pp. 516-527 ◽  
Author(s):  
P.L. McGeer ◽  
H. Akiyama ◽  
S. Itagaki ◽  
E.G. McGeer
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Immune System ◽  
Brain Tissue ◽  
Senile Plaques ◽  
Class Ii ◽  
Dystrophic Neurites ◽  
Reactive Microglia ◽  
Alzheimer Brain ◽  
Alternative Complement

ABSTRACT:Involvement of the immune system in the pathogenesis of Alzheimer's disease was demonstrated in two ways: by the attachment of complement proteins to diseased tissue, and by the activation of cells associated with the immune system. Alzheimer brain tissue was stained immunohistochemically by antibodies to components of the classical, but not the alternative, complement pathway. Antibodies to Clq, C3d, and C4d stained senile plaques, dystrophic neurites, neuropil threads and some tangled neurons. Antibodies to a neoantigenic site on the C5b-9 membrane attack complex stained dystrophic neurites and many tangled neurons, but not senile plaques. Antibodies to Factor P and fraction Bb of Factor B, which are specific for the alternative complement pathway, did not stain Alzheimer brain tissue. The cellular immune response was evaluated by the presence of reactive microglia and by the infiltration of small numbers of T-cells into diseased brain tissue. Reactive microglia were identified by antibodies to HLA-DR, a class II major histocompatibility complex glycoprotein, and by enhanced staining with antibodies to leukocyte common antigen and the FC7RI and FcyRII receptors. T-cells were identified by antibodies to leukocyte common antigen, as well as the CD4 and CD8 surface proteins. Double immunostaining with antibodies to GFAP and MHC class I or class II antigens established that astrocytes, which are GFAP positive, do not express MHC antigens in Alzheimer's disease. Endothelial cells express MHC class I antigens while reactive microglia and some leukocytes express class II antigen.

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1997 ◽  
Vol 3 (4) ◽  
pp. 325-337 ◽  
Author(s):  
Marcia B. Podlisny ◽  
Martin Citron ◽  
Patricia Amarante ◽  
Robin Sherrington ◽  
Weiming Xia ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Alzheimer Brain

Localization and Expression of cdc2 and cdk4 in Alzheimer Brain Tissue

1999 ◽  
Vol 10 (3) ◽  
pp. 192-198 ◽  
Author(s):  
Y. Tsujioka ◽  
M. Takahashi ◽  
Y. Tsuboi ◽  
T. Yamamoto ◽  
T. Yamada
Keyword(s):  
Brain Tissue ◽  
Alzheimer Brain

Cell model for the identification and characterization of prion-like components from Alzheimer brain tissue

2018 ◽  
Vol 497 (3) ◽  
pp. 857-862
Author(s):  
Daniel Markx ◽  
Cornelia Loos ◽  
Stephanie Claus ◽  
Christian Haupt ◽  
Christian Mawrin ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Cell Model ◽  
Alzheimer Brain ◽  
Identification And Characterization

Amplification of Herpes simplex type 1 and Human Herpes type 5 viral DNA from formalin-fixed Alzheimer brain tissue

2005 ◽  
Vol 390 (1) ◽  
pp. 37-41 ◽  
Author(s):  
John D. Rodriguez ◽  
Donald Royall ◽  
Luke T. Daum ◽  
Kathleen Kagan-Hallet ◽  
James P. Chambers
Keyword(s):  
Herpes Simplex ◽  
Brain Tissue ◽  
Herpes Simplex Type ◽  
Human Herpes ◽  
Viral Dna ◽  
Alzheimer Brain ◽  
Formalin Fixed

scholarly journals Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue

PLoS ONE ◽  
2017 ◽  
Vol 12 (12) ◽  
pp. e0189513 ◽  
Author(s):  
Mohamed R. Elnagar ◽  
Anne Byriel Walls ◽  
Gouda K. Helal ◽  
Farid M. Hamada ◽  
Morten Skøtt Thomsen ◽  
...  
Keyword(s):  
Complex Formation ◽  
Brain Tissue ◽  
Α7 Nachr ◽  
Alzheimer Brain

Distribution of clusterin in Alzheimer brain tissue

1992 ◽  
Vol 579 (2) ◽  
pp. 337-341 ◽  
Author(s):  
P.L. McGeer ◽  
T. Kawamata ◽  
D.G. Walker
Keyword(s):  
Brain Tissue ◽  
Alzheimer Brain
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