Pharmacologic Modification of Tumor Blood Flow and Interstitial Fluid Pressure in a Human Tumor Xenograft: Network Analysis and Mechanistic Interpretation

1995 ◽  
Vol 50 (3) ◽  
pp. 429-443 ◽  
Author(s):  
Robert A. Zlotecki ◽  
Laurence T. Baxter ◽  
Yves Boucher ◽  
Rakesh K. Jain
Keyword(s):  
Blood Flow ◽  
Network Analysis ◽  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Human Tumor ◽  
Interstitial Fluid Pressure ◽  
Tumor Xenograft ◽  
Human Tumor Xenograft ◽  
Tumor Blood Flow

Intestinal capillary filtration in acute and chronic portal hypertension

1988 ◽  
Vol 254 (3) ◽  
pp. G339-G345 ◽  
Author(s):  
R. J. Korthuis ◽  
D. A. Kinden ◽  
G. E. Brimer ◽  
K. A. Slattery ◽  
P. Stogsdill ◽  
...  
Keyword(s):  
Blood Flow ◽  
Portal Hypertension ◽  
Capillary Pressure ◽  
Vascular Resistance ◽  
Interstitial Fluid ◽  
Venous Pressure ◽  
Fluid Pressure ◽  
Lymph Flow ◽  
Interstitial Fluid Pressure ◽  
Capillary Filtration

The impact of acute and chronic portal hypertension on the dynamics of intestinal microvascular fluid exchange was examined in anesthetized, fasted, sham-operated control rats with normal portal pressures (CON), during acute elevations in portal pressure (APH) in control rats, and in rats in which chronic portal hypertension (CPH) was produced by calibrated stenosis of the portal vein 10 days prior to the experiments. Although intestinal blood flow and vascular resistance were not altered by APH in control rats, CPH was associated with an increased intestinal blood flow and reduced intestinal vascular resistance when compared with CON and APH. Intestinal capillary pressure and lymph flow were elevated in APH and CPH relative to control values. However, the increase in both variables was greater in CPH. The capillary filtration coefficient was elevated only in CPH. The transcapillary oncotic pressure gradient was not altered by APH or CPH. Interstitial fluid pressure was increased from -1.1 mmHg in CON to 3.9 mmHg during APH and to 5.0 mmHg in CPH. The results of this study indicate that chronic elevations in portal venous pressure produce larger increments in intestinal capillary pressure and filtration rate than do acute elevations in portal venous pressure of the same magnitude. However, the potential edemagenic effects of elevated capillary pressure in both acute and chronic portal hypertension are opposed by increases in lymph flow and interstitial fluid pressure.

Hemodynamics and interstitial fluid pressure in the rat tail

1984 ◽  
Vol 247 (1) ◽  
pp. H80-H87 ◽  
Author(s):  
K. Aukland ◽  
H. Wiig
Keyword(s):  
Blood Flow ◽  
Plasma Volume ◽  
Volume Expansion ◽  
Interstitial Fluid ◽  
Cuff Pressure ◽  
Subcutaneous Tissue ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Venous Stasis ◽  
Plasma Volume Expansion

Blood flow in the rat was measured during pentobarbital anesthesia by plethysmographic and thermometric techniques. Tail arterial and venous pressures (Pa and Pv) were measured by glass micropipettes and interstitial fluid pressure (PIF) by wick-in-needle technique. Large pressure gradients were measured along the tail, Pa decreasing and Pv increasing toward the tip. In the vasoconstricted tail, distal arterial and venous pressures (Pad and Pvd, respectively, 10 cm from the tail root) were 55 and 11% of aortic pressure (PA), while PIF was 0-2 mmHg. Plasma volume expansion increased blood flow by a factor of 10 to 35. Pad rose to 74% and Pvd to 20% of PA. PIF increased to 15 mmHg, in parallel with Pv. Venous stasis (cuff pressure 14.7 mmHg) increased PIF and Pv by 3.5 and 9 mmHg, respectively, while tail volume increased by 0.4 to 1.2%. In conclusion, the large flow increase induced by plasma volume expansion depends strongly on dilation of the tail artery, with two- to threefold increase in internal radius. Simultaneously the tail veins relax and expand. Subcutaneous tissue is compressed between the expanding vessels and the tight skin, and PIF increases almost sufficiently to prevent a rise in net capillary filtration pressure. This immediate edema-preventing mechanism is less efficient during venous stasis, which presumably does not induce "active" dilation of the tail vessels. Similar mechanisms probably exist in other "encapsulated" tissues.

scholarly journals Radiocurability Is Associated with Interstitial Fluid Pressure in Human Tumor Xenografts

Neoplasia ◽  
2009 ◽  
Vol 11 (11) ◽  
pp. 1243-1251 ◽  
Author(s):  
Einar K. Rofstad ◽  
Jon-Vidar Gaustad ◽  
Kjetil G. Brurberg ◽  
Berit Mathiesen ◽  
Kanthi Galappathi ◽  
...  
Keyword(s):  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Human Tumor ◽  
Interstitial Fluid Pressure ◽  
Human Tumor Xenografts ◽  
Tumor Xenografts

Intestinal microvascular exchange during lipid absorption

1988 ◽  
Vol 255 (5) ◽  
pp. G690-G695 ◽  
Author(s):  
D. N. Granger ◽  
R. J. Korthuis ◽  
P. R. Kvietys ◽  
P. Tso
Keyword(s):  
Blood Flow ◽  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Glucose Absorption ◽  
Lymph Flow ◽  
Interstitial Fluid Pressure ◽  
Lipid Absorption ◽  
Oncotic Pressure ◽  
Lymphatic Fluid ◽  
Flow Capillary

The forces and membrane coefficients governing transcapillary and lymphatic fluid fluxes were measured in the cat jejunum before and during perfusion of the gut lumen with oleic acid (5 mM) solubilized with taurocholic acid (10 mM). Net transmucosal fluid flux, lymph flow, capillary pressure (Pc), blood flow, capillary filtration coefficient (Kf,c), and lymph and plasma oncotic pressures were measured under absorptive and nonabsorptive conditions. Interstitial fluid pressure was calculated for the two conditions from measured parameters. Stimulation of lipid absorption resulted in a fivefold increase in lymph flow, a threefold increase in Kf,c, a doubling of blood flow, a 2.5 mmHg increase in Pc, and a 1.0 mmHg reduction in interstitial (lymph) oncotic pressure. Lipid absorption was associated with a 3.6 mmHg increase in interstitial fluid pressure. During lipid absorption, approximately 35% of the absorbed fluid is removed from the mucosal interstitium by lymphatics while capillaries remove the remaining 65%. The results of this study indicate that the effects of lipid absorption on microvascular and lymphatic fluid dynamics are quantitatively different than those produced by glucose absorption. These differences can be largely explained by lipid absorption-induced increases in blood flow and microvascular permeability.

scholarly journals Investigating low-velocity fluid flow in tumours using convection-MRI

2017 ◽  
Author(s):  
Simon Walker-Samuel ◽  
Thomas A. Roberts ◽  
Rajiv Ramasawmy ◽  
Jake Burrell ◽  
S. Peter Johnson ◽  
...  
Keyword(s):  
Fluid Flow ◽  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Tumor Xenograft ◽  
Low Velocity ◽  
Targeting Therapy ◽  
Vascular Flow ◽  
Velocity Flow ◽  
Magnetic Resonance Imaging Mri

AbstractSeveral distinct fluid flow phenemena occur in solid tumours, including intravascular blood flow and interstitial convection. To probe low-velocity flow in tumors resulting from raised interstitial fluid pressure, we have developed a novel magnetic resonance imaging (MRI) technique named convection-MRI. It uses a phase-contrast acquisition with a dual-inversion vascular nulling preparation to separate intra- and extra-vascular flow. Here, we report the results of experiments in flow phantoms, numerical simulations and tumor xenograft models to investigate the technical feasibility of convection-MRI. We report a good correlation between estimates of effective fluid pressure from convection-MRI with gold-standard, invasive measurements of interstitial fluid pressure in mouse models of human colorectal carcinoma and show that convection-MRI can provide insights into the growth and response to vascular-targeting therapy in colorectal cancers.

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