Selective inhibition of TNF-αinduced cell adhesion molecule gene expression by tanapox virus

1998 ◽  
Vol 25 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Mini Paulose ◽  
Brydon L Bennett ◽  
Anthony M Manning ◽  
Karim Essani
Keyword(s):  
Gene Expression ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Selective Inhibition ◽  
Tanapox Virus ◽  
Adhesion Molecule Gene

scholarly journals Modulation of Chemokine- and Adhesion-Molecule Gene Expression and Recruitment of Neutrophil Granulocytes in Rat and Mouse Liver after a Single Gadolinium Chloride or Zymosan Treatment

2018 ◽  
Vol 19 (12) ◽  
pp. 3891 ◽  
Author(s):  
Shakil Ahmad ◽  
Giuliano Ramadori ◽  
Federico Moriconi
Keyword(s):  
Gene Expression ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Kupffer Cells ◽  
Cell Adhesion Molecule ◽  
Gadolinium Chloride ◽  
Neutrophil Granulocytes ◽  
Treatment Regimens ◽  
Adhesion Molecule Gene ◽  
Cell Adhesion Molecule 1

Kupffer cells are professional phagocytes of the liver clearing bacteria from portal blood. Their clearance capacity, however, can be overwhelmed, transforming them into critical mediators of hepatic-injury. We investigated the consequences of selective Kupffer cell-overload by intraperitoneally administering pyrogen-free gadolinium chloride (GdCl3) or Zymosan into rats and into endotoxin-resistant mice (C3H/HeJ). The number of myeloperoxidase-positive (MPO+) cells increased at 3 h mainly around the portal vessel after both GdCl3 and Zymosan treatment. Simultaneously, GdCl3 administration reduced detectability of ED-1+ (but not ED-2) cells near the portal vessel. Serum chemokine (C-X-C motif) ligand 1 (CXCL-1), CXCL-2 and chemokine (C-C motif) ligand 2 (CCL-2) showed a peak at 3 h after both treatment regimens although at a higher extent after Zymosan administration. Accordingly, CXCL-1, CXCL-5 and CCL-2 gene expression in the liver was up-regulated after GdCl3 treatment at 3 h. After Zymosan administration a significant up-regulation of CXCL-1, CXCL-2, CXCL-10, CCL-2, CCL-3 and CCL-20 gene expression in liver at 3 h was observed. After Zymosan administration intracellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) gene expression was up-regulated in rat liver tissue. In C3H/HeJ mice both treatment regimens up-regulated CCL-2 and ICAM-1 gene expression after 3 h and down-regulated platelet endothelial cell adhesion molecule 1 (PECAM-1) gene expression. In conclusion, phagocytosis overload of Kupffer cells causes induction of several CXC, CC-chemokines, upregulation of “positive” adhesion molecule gene expression, down-regulation of the “negative” adhesion molecule PECAM-1 and a recruitment of neutrophil granulocytes in the portal area of the liver of treated rats and mice mainly in close contact to the liver macrophages.

The Regulation of Cell Adhesion Molecule Gene Expression

1994 ◽  
Vol 21 (11) ◽  
pp. 814-820
Author(s):  
Naotaka Shibagaki ◽  
Lian-Jie Li ◽  
S. Wright Caughman
Keyword(s):  
Gene Expression ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Adhesion Molecule Gene
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