Abnormal Polarization and Axon Outgrowth in Retinal Ganglion Cells Lacking the POU-Domain Transcription Factor Brn-3b

2000 ◽  
Vol 16 (2) ◽  
pp. 141-156 ◽  
Author(s):  
Steven W. Wang ◽  
Lin Gan ◽  
Suzanna E. Martin ◽  
William H. Klein
Keyword(s):  
Transcription Factor ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Axon Outgrowth ◽  
Retinal Ganglion ◽  
Pou Domain

scholarly journals POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells.

1996 ◽  
Vol 93 (9) ◽  
pp. 3920-3925 ◽  
Author(s):  
L. Gan ◽  
M. Xiang ◽  
L. Zhou ◽  
D. S. Wagner ◽  
W. H. Klein ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Large Set ◽  
Retinal Ganglion ◽  
Pou Domain

The transcription factor c-jun is activated in retinal ganglion cells in experimental rat glaucoma

2005 ◽  
Vol 80 (5) ◽  
pp. 663-670 ◽  
Author(s):  
Hana Levkovitch-Verbin ◽  
Harry A. Quigley ◽  
Keith R.G. Martin ◽  
Noga Harizman ◽  
Danielle F. Valenta ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Factor C

scholarly journals Cadherin Function Is Required for Axon Outgrowth in Retinal Ganglion Cells In Vivo

Neuron ◽  
1996 ◽  
Vol 17 (5) ◽  
pp. 837-848 ◽  
Author(s):  
Rebecca Riehl ◽  
Karl Johnson ◽  
Roger Bradley ◽  
Gerald B Grunwald ◽  
Elsa Cornel ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Axon Outgrowth ◽  
Retinal Ganglion

Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth

Development ◽  
2002 ◽  
Vol 129 (2) ◽  
pp. 467-477 ◽  
Author(s):  
Steven W. Wang ◽  
Xiuqian Mu ◽  
William J. Bowers ◽  
Dong-Seob Kim ◽  
Daniel J. Plas ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Ganglion Cell ◽  
Retinal Ganglion Cells ◽  
Retinal Ganglion Cell ◽  
Knockout Mice ◽  
Ganglion Cells ◽  
Axon Outgrowth ◽  
Retinal Ganglion ◽  
Double Knockout ◽  
Ganglion Cell Axon

In mice, Brn3 POU domain transcription factors play essential roles in the differentiation and survival of projection neurons within the retina, inner ear, dorsal root and trigeminal ganglia. During retinal ganglion cell differentiation, Brn3b is expressed first, followed by Brn3a and Brn3c. Targeted deletion of Brn3b, but not Brn3a or Brn3c, leads to a loss of most retinal ganglion cells before birth. However, as a few retinal ganglion cells are still present in Brn3b–/– mice, Brn3a and Brn3c may partially compensate for the loss of Brn3b. To examine the role of Brn3c in retinal ganglion cell development, we generated Brn3b/Brn3c double knockout mice and analyzed their retinas and optic chiasms. Retinal ganglion cell axons from double knockout mice were more severely affected than were those from Brn3b-deficient mice, indicating that Brn3c was required for retinal ganglion cell differentiation and could partially compensate for the loss of Brn3b. Moreover, Brn3c had functions in retinal ganglion cell differentiation separate from those of Brn3b. Ipsilateral and misrouted projections at the optic chiasm were overproduced in Brn3b–/– mice but missing were entirely in optic chiasms of Brn3b/Brn3c double knockout mice, suggesting that Brn3c controlled ipsilateral axon production. Forced expression of Brn3c in Brn3b–/– retinal explants restored neurite outgrowth, demonstrating that Brn3c could promote axon outgrowth in the absence of Brn3b. Our results reveal a complex genetic relationship between Brn3b and Brn3c in regulating the retinal ganglion cell axon outgrowth.

scholarly journals Axon Outgrowth Is Regulated by an Intracellular Purine-sensitive Mechanism in Retinal Ganglion Cells

1998 ◽  
Vol 273 (45) ◽  
pp. 29626-29634 ◽  
Author(s):  
Larry I. Benowitz ◽  
Yun Jing ◽  
Raymond Tabibiazar ◽  
Sangmee A. Jo ◽  
Barbara Petrausch ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Axon Outgrowth ◽  
Retinal Ganglion

Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells

Neuron ◽  
1993 ◽  
Vol 11 (4) ◽  
pp. 689-701 ◽  
Author(s):  
Mengqing Xiang ◽  
Lijuan Zhou ◽  
Y.-W. Peng ◽  
Roger L. Eddy ◽  
Thomas B. Shows ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Pou Domain
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