scholarly journals Activating Transcription Factor 3 (ATF3) Protects Retinal Ganglion Cells and Promotes Functional Preservation After Optic Nerve Crush

2020 ◽  
Vol 61 (2) ◽  
pp. 31 ◽  
Author(s):  
Christo Kole ◽  
Benedikt Brommer ◽  
Naoki Nakaya ◽  
Mohor Sengupta ◽  
Luis Bonet-Ponce ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Activating Transcription Factor 3 ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Activating Transcription Factor ◽  
Functional Preservation

Valproate promotes survival of retinal ganglion cells in a rat model of optic nerve crush

Neuroscience ◽  
2012 ◽  
Vol 224 ◽  
pp. 282-293 ◽  
Author(s):  
Z.Z. Zhang ◽  
Y.Y. Gong ◽  
Y.H. Shi ◽  
W. Zhang ◽  
X.H. Qin ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Rat Model ◽  
Ganglion Cells ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush

scholarly journals Loss of Rbfox1 Does Not Affect Survival of Retinal Ganglion Cells Injured by Optic Nerve Crush

2021 ◽  
Vol 15 ◽  
Author(s):  
Lei Gu ◽  
Jacky M. Kwong ◽  
Joseph Caprioli ◽  
Natik Piri
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Gene Networks ◽  
Rna Binding ◽  
Ganglion Cells ◽  
Statistical Significance ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Significant Difference

Rbfox1 is a multifunctional RNA binding protein that regulates alternative splicing, transcription, mRNA stability and translation. Its roles in neurogenesis and neuronal functions are well established. Recent studies also implicate Rbfox1 in the regulation of gene networks that support cell survival during stress. We have earlier characterized the expression of Rbfox1 in amacrine and retinal ganglion cells (RGCs) and showed that deletion of Rbfox1 in adult animals results in depth perception deficiency. The current study investigates the effect of Rbfox1 downregulation on survival of RGCs injured by optic nerve crush (ONC). Seven days after ONC, animals sustained severe degeneration of RGC axons in the optic nerve and significant loss of RGC somas. Semi-quantitative grading of optic nerve damage in control + ONC, control + tamoxifen + ONC, and Rbfox1–/– + ONC groups ranged from 4.6 to 4.8 on a scale of 1 (normal; no degenerated axons were noted) to 5 (total degeneration; all axons showed degenerated organelles, axonal content, and myelin sheath), indicating a severe degeneration. Among these three ONC groups, no statistical significance was observed when any two groups were compared. The number of RGC somas were quantitatively analyzed in superior, inferior, nasal and temporal retinal quadrants at 0.5, 1, and 1.5 mm from the center of the optic disc. The average RGC densities (cells/mm2) were: control 6,438 ± 1,203; control + ONC 2,779 ± 573; control + tamoxifen 6,163 ± 861; control + tamoxifen + ONC 2,573 ± 555; Rbfox1–/– 6,437 ± 893; and Rbfox1–/– + ONC 2,537 ± 526. The RGC loss in control + ONC, control + tamoxifen + ONC and Rbfox1–/– + ONC was 57% (P = 1.44954E-42), 58% (P = 1.37543E-57) and 61% (P = 5.552E-59) compared to RGC numbers in the relevant uninjured groups, respectively. No statistically significant difference was observed between any two groups of uninjured animals or between any two ONC groups. Our data indicate that Rbfox1-mediated pathways have no effect on survival of RGCs injured by ONC.

Upregulation of Gem relates to retinal ganglion cells apoptosis after optic nerve crush in adult rats

2014 ◽  
Vol 45 (5) ◽  
pp. 565-571 ◽  
Author(s):  
Fan Xu ◽  
Hui Huang ◽  
Yu Wu ◽  
Lu Lu ◽  
Li Jiang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Adult Rats ◽  
Nerve Crush

Down-regulation of semaphorin 3F in rat retinal ganglion cells in response to optic nerve crush

2016 ◽  
Vol 34 (5) ◽  
pp. 378-384 ◽  
Author(s):  
Ji-Ae Ko ◽  
Akira Minamoto ◽  
Yosuke Sugimoto ◽  
Yoshiaki Kiuchi
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Down Regulation ◽  
Nerve Crush ◽  
Semaphorin 3F
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