The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability

2000 ◽  
Vol 297 (3) ◽  
pp. 659-672 ◽  
Author(s):  
Thomas Dams ◽  
Günter Auerbach ◽  
Gerd Bader ◽  
Uwe Jacob ◽  
Tarmo Ploom ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dihydrofolate Reductase ◽  
Thermotoga Maritima ◽  
Molecular Features

Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima

2006 ◽  
Vol 358 (5) ◽  
pp. 1328-1340 ◽  
Author(s):  
Guido Hansen ◽  
Axel Harrenga ◽  
Bernd Wieland ◽  
Dietmar Schomburg ◽  
Peter Reinemer
Keyword(s):  
Crystal Structure ◽  
Topoisomerase I ◽  
Thermotoga Maritima ◽  
Full Length

scholarly journals THE APPLICABILITY OF THE CRYSTAL STRUCTURE OF TERMOTOGA MARITIMA 4--GLUCANOTRANSFERASE AS THE TEMPLATE FOR SULOCHRIN AS -GLUCOSIDASE INHIBITORS

2010 ◽  
Vol 9 (3) ◽  
pp. 479-486
Author(s):  
Rizna Triana Dewi ◽  
Yulia Anita ◽  
Enade Perdana Istyastono ◽  
Akhmad Darmawan ◽  
Muhamad Hanafi
Keyword(s):  
Crystal Structure ◽  
Saccharomyces Cerevisiae ◽  
Thermotoga Maritima ◽  
Binding Pocket ◽  
Operating Environment ◽  
High Sequence Identity ◽  
Glucosidase Inhibitor ◽  
Glucosidase Inhibitors ◽  
Docking Method ◽  
Binding Residues

Interaction of sulochrin to active site of glucosidase enzyme of Termotoga maritime has been studied by employing docking method using Molecular Operating Environment (MOE), in comparison with those are reports of established inhibitor α-glucosidase such as acarbose, miglitol and voglibose, and salicinol, as reference compounds. The crystal structure T. maritima α-glucanotransferase (PDB code: 1LWJ) can be employed to serve as the template in the virtual screening of S. cerevisiae α-glucosidase. The comparison between the binding pocket residues of Thermotoga maritima α-glucanotransferase and Saccharomyces cerevisiae α-glucosidase show a high sequence identity and similarity. The result showed that sulochrin could be located in the binding pocket and formed some interactions with the binding residues. The ligands showed proper predicted binding energy (-6.74 - -4.13 kcal/mol) and predicted Ki values (0.011 - 0.939 mM). Sulochrin has a possibility to serve as a lead compound in the development of new α-glucosidase inhibitor.   Keywords: Docking, sulochrin, α-glucosidase Inhibitor, Thermotoga maritime α-glucotransferase, Saccharomyces cerevisiae α-glucosidase, MOE

Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent1

2000 ◽  
Vol 43 (21) ◽  
pp. 3837-3851 ◽  
Author(s):  
Aleem Gangjee ◽  
Jianming Yu ◽  
John J. McGuire ◽  
Vivian Cody ◽  
Nikolai Galitsky ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Dual Inhibitor ◽  
Design Synthesis ◽  
X Ray

scholarly journals Crystal structure of γ-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 Å resolution

2003 ◽  
Vol 54 (1) ◽  
pp. 157-161 ◽  
Author(s):  
Rebecca Page ◽  
Michael S. Nelson ◽  
Frank von Delft ◽  
Marc-André Elsliger ◽  
Jaume M. Canaves ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Thermotoga Maritima

ChemInform Abstract: Synthesis, Crystal Structure and Biological Properties of a New Series of Lipophilic s-Triazines, Dihydrofolate Reductase Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 24 (30) ◽  
pp. no-no
Author(s):  
P. TSITSA ◽  
E. ANTONIADOU-VYZA ◽  
S. J. HAMODRAKAS ◽  
E. E. ELIOPOULOS ◽  
A. TSANTILI-KAKOULIDOU ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dihydrofolate Reductase ◽  
Biological Properties ◽  
Reductase Inhibitors ◽  
Dihydrofolate Reductase Inhibitors

scholarly journals Crystal structure of a tandem cystathionine-β-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 Å resolution

2004 ◽  
Vol 57 (1) ◽  
pp. 213-217 ◽  
Author(s):  
Mitchell D. Miller ◽  
Robert Schwarzenbacher ◽  
Frank von Delft ◽  
Polat Abdubek ◽  
Eileen Ambing ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Thermotoga Maritima ◽  
Cbs Domain ◽  
Domain Protein
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