DNA sequence context modulates the impact of a cisplatin 1,2-d(GpG) intrastrand cross-link on the conformational and thermodynamic properties of duplex DNA

2000 ◽  
Vol 296 (3) ◽  
pp. 803-812 ◽  
Author(s):  
Daniel S Pilch ◽  
Shari U Dunham ◽  
Elizabeth R Jamieson ◽  
Stephen J Lippard ◽  
Kenneth J Breslauer
Keyword(s):  
Thermodynamic Properties ◽  
Dna Sequence ◽  
Duplex Dna ◽  
Cross Link ◽  
Sequence Context ◽  
The Impact

DNA Sequence Context and Multiplex Hybridization Reactions:  Melting Studies of Heteromorphic Duplex DNA Complexes

2003 ◽  
Vol 125 (1) ◽  
pp. 141-150 ◽  
Author(s):  
Peter V. Riccelli ◽  
Timothy S. Hall ◽  
Petr Pancoska ◽  
Kathleen E. Mandell ◽  
Albert S. Benight
Keyword(s):  
Dna Sequence ◽  
Duplex Dna ◽  
Dna Complexes ◽  
Sequence Context

scholarly journals DNA Sequence Context as a Determinant of the Quantity and Chemistry of Guanine Oxidation Produced by Hydroxyl Radicals and One-electron Oxidants

2008 ◽  
Vol 283 (51) ◽  
pp. 35569-35578 ◽  
Author(s):  
Yelena Margolin ◽  
Vladimir Shafirovich ◽  
Nicholas E. Geacintov ◽  
Michael S. DeMott ◽  
Peter C. Dedon
Keyword(s):  
Dna Sequence ◽  
Hydroxyl Radicals ◽  
Sequence Context ◽  
Guanine Oxidation

An FE Based Surrogate Model for Predicting the Impact of a SMA Twist System on the Helicopter Performance

2019 ◽  
Author(s):  
Salvatore Ameduri ◽  
Antonio Concilio ◽  
Rohin Kumar Majeti
Keyword(s):  
Phase Transition ◽  
Shape Memory Alloy ◽  
Specific Property ◽  
Critical Parameters ◽  
Cross Link ◽  
Improve Performance ◽  
Actuation System ◽  
Input And Output ◽  
Sma Actuator ◽  
The Impact

Abstract This work focuses on a surrogate predictive model, conceived to estimate the impact on blade twist law of a Shape Memory Alloy actuation system. The basic idea is to integrate the pre-existing blade structure with a pre-twisted SMA tube. Due to the specific property of recovering deformation during phase transition, the SMA element can transmit angular deformations and alter the original twist to improve performance when required. The model includes two main modules. The first one targets the SMA actuator and simulates the transmission of twist against some critical parameters (tube extension and location along the blade span and level of activation). The second module receives as input the modified twist law and the updated mechanical features due to the SMA and gives in output an estimate of the performance produced by the system. After an overview on input and output parameters and their cross link, a description of the SMA predicting core is provided. A parameterization is then organized to illustrate the impact of the morphing system onto the blade and on the twist law. On this basis, an additional parameterization is implemented, now focusing on the effects on performance of the proposed system.

scholarly journals Quantifying Influences on Intragenomic Mutation Rate

2020 ◽  
Vol 10 (8) ◽  
pp. 2641-2652
Author(s):  
Helmut Simon ◽  
Gavin Huttley
Keyword(s):  
Point Mutations ◽  
Population Based ◽  
Genomic Diversity ◽  
Ensembl Database ◽  
Sequence Context ◽  
The Public ◽  
Recombination Hotspots ◽  
Strand Asymmetry ◽  
The Impact ◽  
Central Base

We report work to quantify the impact on the probability of human genome polymorphism both of recombination and of sequence context at different scales. We use population-based analyses of data on human genetic variants obtained from the public Ensembl database. For recombination, we calculate the variance due to recombination and the probability that a recombination event causes a mutation. We employ novel statistical procedures to take account of the spatial auto-correlation of recombination and mutation rates along the genome. Our results support the view that genomic diversity in recombination hotspots arises largely from a direct effect of recombination on mutation rather than predominantly from the effect of selective sweeps. We also use the statistic of variance due to context to compare the effect on the probability of polymorphism of contexts of various sizes. We find that when the 12 point mutations are considered separately, variance due to context increases significantly as we move from 3-mer to 5-mer and from 5-mer to 7-mer contexts. However, when all mutations are considered in aggregate, these differences are outweighed by the effect of interaction between the central base and its immediate neighbors. This interaction is itself dominated by the transition mutations, including, but not limited to, the CpG effect. We also demonstrate strand-asymmetry of contextual influence in intronic regions, which is hypothesized to be a result of transcription coupled DNA repair. We consider the extent to which the measures we have used can be used to meaningfully compare the relative magnitudes of the impact of recombination and context on mutation.

Evaluation of thermodynamic properties and correlation of L-glutamic acid solubility in some aqueous chloride solutions from 298.15 to 323.15 K

2019 ◽  
Vol 97 (8) ◽  
pp. 615-620
Author(s):  
Mustafa Jaipallah Abualreish ◽  
Adel Noubigh
Keyword(s):  
Thermodynamic Properties ◽  
Aqueous Solutions ◽  
Glutamic Acid ◽  
Pure Water ◽  
Gravimetric Method ◽  
Chloride Salt ◽  
Salting Out ◽  
Chloride Solutions ◽  
Aqueous Chloride ◽  
The Impact

This paper investigates the solubility–temperature dependence data for L-glutamic acid (Glu) in water and in some chloride salt (NaCl and KCl) aqueous solutions. Solubility data were determined from 293.15 to 318.15 K under atmospheric pressure by using a thermostatted reactor and the gravimetric method. After the investigation of the impact of inorganic salts on the solvency of Glu, it was found that the salting-out effect decreases in the following order: sodium chloride > potassium chloride. Results demonstrated that the solubility, in unadulterated water and in aqueous chloride solutions, increased with a rising temperature. The experimental data were well correlated by the semi-empirical equation. Using the measured solubilities, the standard molar thermodynamic properties of transfer of Glu (ΔtrG°, ΔtrH°, and ΔtrS°) from pure water to aqueous solutions of the chloride salts were estimated.

Advanced Modeling of Fluid Thermodynamic Properties for Gas Turbine Performance Simulation

2008 ◽  
Author(s):  
Vishal Sethi ◽  
Fulvio Diara ◽  
Sina Atabak ◽  
Anthony Jackson ◽  
Arjun Bala ◽  
...  
Keyword(s):  
Thermodynamic Properties ◽  
Gas Turbine ◽  
Fluid Model ◽  
Simulation Software ◽  
Working Fluid ◽  
Performance Simulation ◽  
Turbine Performance ◽  
Fluid Properties ◽  
Convergence Problems ◽  
The Impact

This paper describes the structure of an advanced fluid thermodynamic model which has been developed for a novel advanced gas turbine simulation environment called PROOSIS. PROOSIS (PRopulsion Object Oriented SImulation Software) is part of the VIVACE-ECP (Value Improvement through a Virtual Aeronautical Collaborative Enterprise - European Cycle Programme) project. The main objective of the paper is to determine a way to achieve an accurate, robust and reliable fluid model. The results obtained demonstrate that accurate modeling of the working fluid is essential to avoid convergence problems of the thermodynamic functions thereby increasing the accuracy of calculated fluid properties. Additionally, the impact of accurately modeling fuel thermodynamic properties, at the point of the injection, is discussed.

DNA spontaneous mutation and its role in the evolution of GC-content: assessing the impact of the genetic sequence

2015 ◽  
Vol 17 (12) ◽  
pp. 7754-7760 ◽  
Author(s):  
José P. Cerón-Carrasco ◽  
Denis Jacquemin
Keyword(s):  
Dna Sequence ◽  
Base Pair ◽  
Spontaneous Mutation ◽  
Gc Content ◽  
Genetic Sequence ◽  
The Impact

We use theoretical tools to investigate the possible role played by a DNA sequence in the base pair tautomerization phenomena.

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