Identification and Characterization of K12 (SECTM1), a Novel Human Gene That Encodes a Golgi-Associated Protein with Transmembrane and Secreted Isoforms

Genomics ◽  
1998 ◽  
Vol 47 (3) ◽  
pp. 327-340 ◽  
Author(s):  
Kimberly A. Slentz-Kesler ◽  
Laura P. Hale ◽  
Russel E. Kaufman
Keyword(s):  
Human Gene ◽  
Identification And Characterization

scholarly journals Identification and Characterization of the Murine and Human Gene Encoding the Tuberoinfundibular Peptide of 39 Residues

Endocrinology ◽  
2002 ◽  
Vol 143 (3) ◽  
pp. 1047-1057 ◽  
Author(s):  
Markus R. John ◽  
Maya Arai ◽  
David A. Rubin ◽  
Kenneth B. Jonsson ◽  
Harald Jüppner
Keyword(s):  
Human Gene ◽  
Gene Encoding ◽  
Tuberoinfundibular Peptide ◽  
Identification And Characterization

Identification and characterization of C3orf6, a new conserved human gene mapping to chromosome 3q28

Gene ◽  
2003 ◽  
Vol 314 ◽  
pp. 113-120 ◽  
Author(s):  
G. Vazza ◽  
S. Picelli ◽  
A. Bozzato ◽  
M.L. Mostacciuolo
Keyword(s):  
Gene Mapping ◽  
Human Gene ◽  
Human Gene Mapping ◽  
Identification And Characterization

Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1

1998 ◽  
Vol 82 (3-4) ◽  
pp. 147-152 ◽  
Author(s):  
M. Kimura ◽  
Y. Matsuda ◽  
T. Yoshioka ◽  
N. Sumi ◽  
Y. Okano
Keyword(s):  
Human Gene ◽  
Identification And Characterization

The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+

2012 ◽  
Vol 443 (1) ◽  
pp. 241-247 ◽  
Author(s):  
Gennaro Agrimi ◽  
Annamaria Russo ◽  
Pasquale Scarcia ◽  
Ferdinando Palmieri
Keyword(s):  
Human Gene ◽  
Main Function ◽  
Human Tissues ◽  
Solute Carrier Family ◽  
Peroxisomal Membrane ◽  
Mitochondrial Carrier ◽  
Mitochondrial Carrier Family ◽  
Solute Carrier ◽  
Identification And Characterization

The essential cofactors CoA, FAD and NAD+ are synthesized outside the peroxisomes and therefore must be transported into the peroxisomal matrix where they are required for important processes. In the present study we have functionally identified and characterized SLC25A17 (solute carrier family 25 member 17), which is the only member of the mitochondrial carrier family that has previously been shown to be localized in the peroxisomal membrane. Recombinant and purified SLC25A17 was reconstituted into liposomes. Its transport properties and kinetic parameters demonstrate that SLC25A17 is a transporter of CoA, FAD, FMN and AMP, and to a lesser extent of NAD+, PAP (adenosine 3′,5′-diphosphate) and ADP. SLC25A17 functioned almost exclusively by a counter-exchange mechanism, was saturable and was inhibited by pyridoxal 5′-phosphate and other mitochondrial carrier inhibitors. It was expressed to various degrees in all of the human tissues examined. Its main function is probably to transport free CoA, FAD and NAD+ into peroxisomes in exchange for intraperoxisomally generated PAP, FMN and AMP. The present paper is the first report describing the identification and characterization of a transporter for multiple free cofactors in peroxisomes.

scholarly journals Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA)

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e34838 ◽  
Author(s):  
Kristoffer Søberg ◽  
Anja C. V. Larsen ◽  
Mandy Diskar ◽  
Paul H. Backe ◽  
Magnar Bjørås ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Human Gene ◽  
Catalytic Subunit ◽  
Novel Mutations ◽  
Gene Encoding ◽  
Identification And Characterization ◽  
Kinase A

Identification and Characterization of a New Human Gene (APOC4) in the Apolipoprotein E, C-I, and C-II Gene Locus

Genomics ◽  
1995 ◽  
Vol 28 (2) ◽  
pp. 291-300 ◽  
Author(s):  
Charles M. Allan ◽  
David Walker ◽  
Jere P. Segrest ◽  
John M. Taylor
Keyword(s):  
Apolipoprotein E ◽  
Gene Locus ◽  
Human Gene ◽  
Identification And Characterization
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