Toxicity of Divinylbenzene-55 for B6C3F1 Mice in a Two-Week Inhalation Study

1997 ◽  
Vol 39 (2) ◽  
pp. 89-100 ◽  
Author(s):  
D Morgan
Keyword(s):  
Inhalation Study ◽  
B6c3f1 Mice

scholarly journals A 90-Day Chloroform Inhalation Study in Female and Male B6C3F1 Mice: Implications for Cancer Risk Assessment

1996 ◽  
Vol 30 (1) ◽  
pp. 118-137 ◽  
Author(s):  
JEFFREY L. LARSON ◽  
MICHAEL V. TEMPLIN ◽  
DOUGLAS C. WOLF ◽  
KEITH C. JAMISON ◽  
JOEL R. LEINNINGER ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Cancer Risk Assessment ◽  
Inhalation Study ◽  
B6c3f1 Mice

A subchronic inhalation study on the toxicologic potential of ethylene oxide in B6C3F1 mice

1984 ◽  
Vol 76 (3) ◽  
pp. 510-518 ◽  
Author(s):  
William M. Snellings ◽  
Carrol S. Weil ◽  
R.R. Maronpot
Keyword(s):  
Ethylene Oxide ◽  
Inhalation Study ◽  
B6c3f1 Mice

scholarly journals Toxicity of Divinylbenzene-55 for B6C3F1 Mice in a Two-Week Inhalation Study

1997 ◽  
Vol 39 (2) ◽  
pp. 89-100
Author(s):  
Daniel L. Morgan ◽  
Joel F. Mahler ◽  
Ralph E. Wilson ◽  
Michael P. Moorman ◽  
Herman C. Price ◽  
...  
Keyword(s):  
Inhalation Study ◽  
B6c3f1 Mice

scholarly journals A 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysematous changes following smoking cessation or switching to e-vapor products

2021 ◽  
Vol 5 ◽  
pp. 239784732199587
Author(s):  
Ashutosh Kumar ◽  
Ulrike Kogel ◽  
Marja Talikka ◽  
Celine Merg ◽  
Emmanuel Guedj ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Cigarette Smoke ◽  
Pulmonary Inflammation ◽  
Clinical Signs ◽  
Inhalation Study ◽  
Toxicology Study ◽  
Nasal Tissue ◽  
Product Switching ◽  
The Impact

Cigarette smoking causes serious diseases, including lung cancer, atherosclerotic coronary artery disease, peripheral vascular disease, chronic bronchitis, and emphysema. While cessation remains the most effective approach to minimize smoking-related disease, alternative non-combustible tobacco-derived nicotine-containing products may reduce disease risks among those unable or unwilling to quit. E-vapor aerosols typically contain significantly lower levels of smoke-related harmful and potentially harmful constituents; however, health risks of long-term inhalation exposures are unknown. We designed a 7-month inhalation study in C57BL/6 mice to evaluate long-term respiratory toxicity of e-vapor aerosols compared to cigarette smoke and to assess the impact of smoking cessation (Cessation group) or switching to an e-vapor product (Switching group) after 3 months of exposure to 3R4F cigarette smoke (CS). There were no significant changes in in-life observations (body weights, clinical signs) in e-vapor groups compared to the Sham Control. The 3R4F CS group showed reduced respiratory function during exposure and had lower body weight and showed transient signs of distress post-exposure. Following 7 months of exposure, e-vapor aerosols resulted in no or minimal increase in pulmonary inflammation, while exposure to 3R4F CS led to impairment of lung function and caused marked lung inflammation and emphysematous changes. Biological changes observed in the Switching group were similar to the Cessation group. 3R4F CS exposure dysregulated the lung and nasal tissue transcriptome, while these molecular effects were substantially lower in the e-vapor group. Results from this study demonstrate that in comparison with 3R4F CS, e-vapor aerosols induce substantially lower biological responses including pulmonary inflammation and emphysematous changes, and that complete switching from CS to e-vapor products significantly reduces biological changes associated with CS in C57BL/6 mice.

Thirteen-week toxicology studies of 1-amino-2,4-dibromoanthraquinone in Fischer 344N rats and B6C3F1 mice

1986 ◽  
Vol 82 (3) ◽  
pp. 389-404 ◽  
Author(s):  
Robert W. Fleischman ◽  
Henry J. Esber ◽  
Miasnig Hagopian ◽  
Herman S. Lilja ◽  
James Huff
Keyword(s):  
B6c3f1 Mice

GLYCIDOL MODULATION OF THE IMMUNE RESPONSES IN FEMALE B6C3F1 MICE

2000 ◽  
Vol 23 (3) ◽  
pp. 433-457 ◽  
Author(s):  
T. L. Guo ◽  
J. A. McCay ◽  
R. D. Brown ◽  
D. L. Musgrove ◽  
L. Butterworth ◽  
...  
Keyword(s):  
Immune Responses ◽  
B6c3f1 Mice
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