Biliary Epithelial Cell Proliferation Following α-Naphthylisothiocyanate (ANIT) Treatment: Relationship to Bile Duct Obstruction

1995 ◽  
Vol 26 (1) ◽  
pp. 51-62 ◽  
Author(s):  
D Kossor
Keyword(s):  
Cell Proliferation ◽  
Bile Duct ◽  
Epithelial Cell ◽  
Bile Duct Obstruction ◽  
Epithelial Cell Proliferation ◽  
Biliary Epithelial Cell ◽  
Duct Obstruction ◽  
Treatment Relationship

Biliary Epithelial Cell Proliferation Following α-Naphthylisothiocyanate (ANIT) Treatment: Relationship to Bile Duct Obstruction

1995 ◽  
Vol 26 (1) ◽  
pp. 51-62
Author(s):  
DAVID C. KOSSOR ◽  
ROBIN S. GOLDSTEIN ◽  
WINNIE NGO ◽  
DENNIS B. DENICOLA ◽  
THOMAS B. LEONARD ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bile Duct ◽  
Epithelial Cell ◽  
Bile Duct Obstruction ◽  
Epithelial Cell Proliferation ◽  
Biliary Epithelial Cell ◽  
Duct Obstruction ◽  
Treatment Relationship

scholarly journals Effect of Rotavirus Strain on the Murine Model of Biliary Atresia

2006 ◽  
Vol 81 (4) ◽  
pp. 1671-1679 ◽  
Author(s):  
Steven R. Allen ◽  
Mubeen Jafri ◽  
Bryan Donnelly ◽  
Monica McNeal ◽  
David Witte ◽  
...  
Keyword(s):  
Bile Duct ◽  
Epithelial Cell ◽  
Biliary Atresia ◽  
Murine Model ◽  
Clinical Signs ◽  
Bile Duct Obstruction ◽  
Biliary Epithelial Cell ◽  
Newborn Mice ◽  
Live Virus ◽  
Duct Obstruction

ABSTRACT Biliary atresia is a devastating disorder of the newborn in which afflicted infants develop inflammation and fibrosis of the extrahepatic biliary tract, resulting in cirrhosis and end-stage liver disease. Infection with a virus is thought to be a contributing factor in the etiology of biliary atresia. In the murine model of biliary atresia, perinatal exposure to rhesus rotavirus (RRV) results in biliary epithelial cell infection causing bile duct obstruction. The purpose of this study was to determine if tropism for the biliary epithelial cell was unique to RRV. Newborn mice underwent intraperitoneal injection with five strains of rotavirus: RRV (simian), SA11-FM (simian/bovine), SA11-SM (simian), EDIM (murine), and Wa (human). RRV and SA11-FM caused clinical manifestations of bile duct obstruction and high mortality. SA11-SM caused clinical signs of hepatobiliary injury but the mortality was markedly reduced. EDIM and Wa caused no sign of hepatobiliary disease. The systemic and temporal distribution of viral protein and live virus varied according to the injected strain. Immunohistochemistry revealed that RRV and SA11-FM targeted the biliary epithelial cells. In contrast, SA11-SM was found in the liver but in not in the biliary epithelium. These results indicate that strain-specific characteristics dictate tropism for cells of hepatobiliary origin which in turn impact the ability to induce the murine model of biliary atresia.

Bile Duct Obstruction Is not a Prerequisite for Type I Biliary Epithelial Cell Hyperplasia

1998 ◽  
Vol 152 (2) ◽  
pp. 327-338 ◽  
Author(s):  
David C. Kossor ◽  
Paul C. Meunier ◽  
Deanne M. Dulik ◽  
Thomas B. Leonard ◽  
Robin S. Goldstein
Keyword(s):  
Bile Duct ◽  
Epithelial Cell ◽  
Bile Duct Obstruction ◽  
Type I ◽  
Biliary Epithelial Cell ◽  
Cell Hyperplasia ◽  
Duct Obstruction

scholarly journals Ezrin-Radixin-Moesin-Binding Phosphoprotein (EBP50), an Estrogen-Inducible Scaffold Protein, Contributes to Biliary Epithelial Cell Proliferation

2009 ◽  
Vol 174 (3) ◽  
pp. 869-880 ◽  
Author(s):  
Laura Fouassier ◽  
Peter Rosenberg ◽  
Martine Mergey ◽  
Bruno Saubaméa ◽  
Audrey Clapéron ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Epithelial Cell ◽  
Scaffold Protein ◽  
Epithelial Cell Proliferation ◽  
Biliary Epithelial Cell

scholarly journals Effects of bile acids on biliary epithelial cell proliferation and portal fibroblast activation using rat liver slices

2006 ◽  
Vol 86 (3) ◽  
pp. 275-285 ◽  
Author(s):  
Haude Clouzeau-Girard ◽  
Christelle Guyot ◽  
Chantal Combe ◽  
Valérie Moronvalle-Halley ◽  
Chantal Housset ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Epithelial Cell ◽  
Bile Acids ◽  
Rat Liver ◽  
Epithelial Cell Proliferation ◽  
Biliary Epithelial Cell ◽  
Fibroblast Activation ◽  
Liver Slices ◽  
Portal Fibroblast
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