Toxoplasma gondii: Genetic Selection of Tethered Dihydrofolate Reductase-Thymidylate Synthase Fusion Proteins

Alexia A. Belperron; Barbara A. Fox; Toshihiro Horii; David J. Bzik

doi:10.1006/expr.2001.4631

Toxoplasma gondii: Genetic Selection of Tethered Dihydrofolate Reductase-Thymidylate Synthase Fusion Proteins

Experimental Parasitology ◽

10.1006/expr.2001.4631 ◽

2001 ◽

Vol 98 (3) ◽

pp. 167-170 ◽

Cited By ~ 3

Author(s):

Alexia A. Belperron ◽

Barbara A. Fox ◽

Toshihiro Horii ◽

David J. Bzik

Keyword(s):

Toxoplasma Gondii ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Fusion Proteins ◽

Genetic Selection ◽

Selection Of

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Structural studies of dihydrofolate reductase-thymidylate synthase from Toxoplasma gondii and dynamin 1 from Rattus norvegicus.

10.1349/ddlp.235 ◽

2008 ◽

Author(s):

Kimberly A. W. Peaslee

Keyword(s):

Toxoplasma Gondii ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Rattus Norvegicus ◽

Structural Studies

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Toward Rational Design of Species-Specific Inhibitors of Pneumocystis carinii Thymidylate Synthase and Toxoplasma gondii Dihydrofolate Reductase-Thymidylate Synthase

Journal of Eukaryotic Microbiology ◽

10.1111/j.1550-7408.2001.tb00507.x ◽

2001 ◽

Vol 48 ◽

pp. 174s-175s

Author(s):

KIMBERLY A.W. PEASLEE ◽

AMY C. ANDERSON

Keyword(s):

Toxoplasma Gondii ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Rational Design ◽

Pneumocystis Carinii ◽

Species Specific ◽

Specific Inhibitors

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Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.90.24.11703 ◽

1993 ◽

Vol 90 (24) ◽

pp. 11703-11707 ◽

Cited By ~ 239

Author(s):

R. G. Donald ◽

D. S. Roos

Keyword(s):

Drug Resistance ◽

Toxoplasma Gondii ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Resistance Mutations ◽

Drug Resistance Mutations

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Transcript initiation, polyadenylation, and functional promoter mapping for the dihydrofolate reductase-thymidylate synthase gene of Toxoplasma gondii

Molecular and Biochemical Parasitology ◽

10.1016/j.molbiopara.2003.12.015 ◽

2004 ◽

Vol 137 (2) ◽

pp. 229-238 ◽

Cited By ~ 22

Author(s):

Mariana Matrajt ◽

Craig D. Platt ◽

Anurag D. Sagar ◽

A. Lindsay ◽

C. Moulton ◽

...

Keyword(s):

Toxoplasma Gondii ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Transcript Initiation

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Stable transformation of Toxoplasma gondii based on a pyrimethamine resistant trifunctional dihydrofolate reductase-cytosine deaminase-thymidylate synthase gene that confers sensitivity to 5-fluorocytosine

Molecular and Biochemical Parasitology ◽

10.1016/s0166-6851(98)00154-6 ◽

1999 ◽

Vol 98 (1) ◽

pp. 93-103 ◽

Cited By ~ 22

Author(s):

BarbaraA. Fox ◽

AlexiaA. Belperron ◽

DavidJ. Bzik

Keyword(s):

Toxoplasma Gondii ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Cytosine Deaminase ◽

Stable Transformation

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Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation

Protein Science ◽

10.1002/pro.2300 ◽

2013 ◽

Vol 22 (9) ◽

pp. 1161-1173 ◽

Cited By ~ 7

Author(s):

Mark J. Landau ◽

Hitesh Sharma ◽

Karen S. Anderson

Keyword(s):

Toxoplasma Gondii ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Allosteric Regulation ◽

Peptide Inhibitors

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Homologous recombination and gene replacement at the dihydrofolate reductase-thymidylate synthase locus in Toxoplasma gondii

Molecular and Biochemical Parasitology ◽

10.1016/0166-6851(94)90060-4 ◽

1994 ◽

Vol 63 (2) ◽

pp. 243-253 ◽

Cited By ~ 69

Author(s):

Robert G.K. Donald ◽

David S. Roos

Keyword(s):

Toxoplasma Gondii ◽

Homologous Recombination ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Gene Replacement

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Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase–dihydrofolate reductase

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.12.039 ◽

2014 ◽

Vol 24 (4) ◽

pp. 1232-1235 ◽

Cited By ~ 8

Author(s):

Hitesh Sharma ◽

Mark J. Landau ◽

Todd J. Sullivan ◽

Vidya P. Kumar ◽

Markus K. Dahlgren ◽

...

Keyword(s):

Toxoplasma Gondii ◽

Virtual Screening ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Allosteric Inhibitors

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Primary structure of the dihydrofolate reductase-thymidylate synthase gene from Toxoplasma gondii.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)53249-x ◽

1993 ◽

Vol 268 (9) ◽

pp. 6269-6280

Author(s):

D.S. Roos

Keyword(s):

Toxoplasma Gondii ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Primary Structure

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Toxoplasma gondii: generation of novel truncation mutations in the linker domain of dihydrofolate reductase–thymidylate synthase

Experimental Parasitology ◽

10.1016/j.exppara.2004.03.002 ◽

2004 ◽

Vol 106 (3-4) ◽

pp. 179-182 ◽

Cited By ~ 6

Author(s):

Alexia A. Belperron ◽

Barbara A. Fox ◽

Robert H. O’Neil ◽

Kimberly A.W. Peaslee ◽

Toshihiro Horii ◽

...

Keyword(s):

Toxoplasma Gondii ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Linker Domain

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