scholarly journals Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation

2013 ◽  
Vol 22 (9) ◽  
pp. 1161-1173 ◽  
Author(s):  
Mark J. Landau ◽  
Hitesh Sharma ◽  
Karen S. Anderson
Keyword(s):  
Toxoplasma Gondii ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Allosteric Regulation ◽  
Peptide Inhibitors

scholarly journals Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase–dihydrofolate reductase

2014 ◽  
Vol 24 (4) ◽  
pp. 1232-1235 ◽  
Author(s):  
Hitesh Sharma ◽  
Mark J. Landau ◽  
Todd J. Sullivan ◽  
Vidya P. Kumar ◽  
Markus K. Dahlgren ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Virtual Screening ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Allosteric Inhibitors

Toxoplasma gondii: Genetic Selection of Tethered Dihydrofolate Reductase-Thymidylate Synthase Fusion Proteins

2001 ◽  
Vol 98 (3) ◽  
pp. 167-170 ◽  
Author(s):  
Alexia A. Belperron ◽  
Barbara A. Fox ◽  
Toshihiro Horii ◽  
David J. Bzik
Keyword(s):  
Toxoplasma Gondii ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Fusion Proteins ◽  
Genetic Selection ◽  
Selection Of

Toxoplasma gondii: generation of novel truncation mutations in the linker domain of dihydrofolate reductase–thymidylate synthase

2004 ◽  
Vol 106 (3-4) ◽  
pp. 179-182 ◽  
Author(s):  
Alexia A. Belperron ◽  
Barbara A. Fox ◽  
Robert H. O’Neil ◽  
Kimberly A.W. Peaslee ◽  
Toshihiro Horii ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Linker Domain
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