Chronic Pain after Clip-Compression Injury of the Rat Spinal Cord

2002 ◽  
Vol 178 (1) ◽  
pp. 33-48 ◽  
Author(s):  
Jamie C. Bruce ◽  
Mark A. Oatway ◽  
Lynne C. Weaver
Keyword(s):  
Spinal Cord ◽  
Chronic Pain ◽  
Rat Spinal Cord ◽  
Compression Injury

Effects of α-Phenyl-N-tert-butyl Nitrone (PBN) on Compression Injury of Rat Spinal Cord

1997 ◽  
Vol 27 (2) ◽  
pp. 187-196 ◽  
Author(s):  
Gw Lin Li ◽  
Mohammad Farooque ◽  
Anders Holtz ◽  
Yngve Olson
Keyword(s):  
Spinal Cord ◽  
Rat Spinal Cord ◽  
Compression Injury ◽  
Tert Butyl

Effect of 21-aminosteroid on extracellular energy-related metabolites and amino acids after compression injury of rat spinal cord

1997 ◽  
Vol 113 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Mohammad Farooque ◽  
Yngve Olsson ◽  
Lars Hillered ◽  
Anders Holtz
Keyword(s):  
Amino Acids ◽  
Spinal Cord ◽  
Rat Spinal Cord ◽  
Compression Injury

scholarly journals Neuroligins Facilitate The Development of Bone Cancer Pain via Regulating Synaptic Transmission

2021 ◽  
Author(s):  
Xianqiao Xie ◽  
Yang Li ◽  
Shanchun Su ◽  
Xiaohui Li ◽  
Xueqin Xu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Chronic Pain ◽  
Cancer Pain ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Rat Spinal Cord ◽  
Spinal Dorsal

Abstract Background The underlying mechanism of chronic pain involves the plasticity in synaptic receptors and neurotransmitters. This study aimed to investigate potential roles of neuroligins (NLs) within the spinal dorsal horn of rats in a newly established bone cancer pain (BCP) model. Methods Using our rat BCP model, we assessed pain hypersensitivity over time. Quantitative real-time polymerase chain reaction and Western blot analysis were performed to investigate NL expression, and NLs were overexpressed in the rat spinal cord using lentiviral vectors. Immunofluorescence staining and whole-cell patch-clamp recordings were deployed to investigate the role of NLs in the development of BCP. Results We observed reduced expression levels of NL1 and NL2, but not NL3, within the rat spinal cord, which were found to be associated with and essential for the development of BCP in our model. Accordingly, NL1 or NL2 overexpression in the spinal cord alleviated mechanical hypersensitivity of rats. Electrophysiological experiments indicated that NL1 and NL2 are involved in BCP via regulating γ-aminobutyric acid-ergic interneuronal synapses and the activity of glutamatergic interneuronal synapses, respectively. Conclusions Our observations unravel the role of NLs in cancer-related chronic pain and further suggest that inhibitory mechanisms are central features of BCP in the spinal dorsal horn. These results provide a new perspective and basis for subsequent studies elucidating the onset and progression of BCP.

Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models

2003 ◽  
Vol 17 (12) ◽  
pp. 2750-2754 ◽  
Author(s):  
Ji Zhang ◽  
Cyrla Hoffert ◽  
Huy Khang Vu ◽  
Thierry Groblewski ◽  
Sultan Ahmad ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Chronic Pain ◽  
Receptor Expression ◽  
Cb2 Receptor ◽  
Rat Spinal Cord ◽  
Pain Models
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