Effects of Moderate Hypothermia on Extracellular Lactic Acid and Amino Acids after Severe Compression Injury of Rat Spinal Cord

1997 ◽  
Vol 14 (1) ◽  
pp. 63-69 ◽  
Author(s):  
MOHAMMAD FAROOQUE ◽  
LARS HILLERED ◽  
ANDERS HOLTZ ◽  
YNGVE OLSSON
Keyword(s):  
Amino Acids ◽  
Spinal Cord ◽  
Lactic Acid ◽  
Moderate Hypothermia ◽  
Rat Spinal Cord ◽  
Compression Injury

Effect of 21-aminosteroid on extracellular energy-related metabolites and amino acids after compression injury of rat spinal cord

1997 ◽  
Vol 113 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Mohammad Farooque ◽  
Yngve Olsson ◽  
Lars Hillered ◽  
Anders Holtz
Keyword(s):  
Amino Acids ◽  
Spinal Cord ◽  
Rat Spinal Cord ◽  
Compression Injury

Effects of α-Phenyl-N-tert-butyl Nitrone (PBN) on Compression Injury of Rat Spinal Cord

1997 ◽  
Vol 27 (2) ◽  
pp. 187-196 ◽  
Author(s):  
Gw Lin Li ◽  
Mohammad Farooque ◽  
Anders Holtz ◽  
Yngve Olson
Keyword(s):  
Spinal Cord ◽  
Rat Spinal Cord ◽  
Compression Injury ◽  
Tert Butyl

Lactic acid potentiates bradykinin- and low-pH-induced release of CGRP from rat spinal cord slices

1997 ◽  
Vol 273 (1) ◽  
pp. E92-E98 ◽  
Author(s):  
X. Wang ◽  
R. R. Fiscus
Keyword(s):  
Spinal Cord ◽  
Septic Shock ◽  
Lactic Acid ◽  
Low Ph ◽  
Sensory Nerves ◽  
Strenuous Exercise ◽  
Rat Spinal Cord ◽  
Tissue Ischemia ◽  
Cgrp Release ◽  
Calcitonin Gene

Previous data from our laboratory have shown that calcitonin gene-related peptide (CGRP) is released into the circulation during pathogenesis of endotoxic, hemorrhagic, and septic shock and appears to mediate in part the vascular problems of shock. Elevations in the levels of bradykinin (BK) and lactic acid and lowering of tissue pH also occur during shock and could be involved in CGRP release. In the present study, we have tested whether lactic acid, alone or in combination with BK or low pH, triggers release of CGRP-like immunoreactivity (CGRP-LI) from sensory nerves, using rat spinal cord slices as a tissue model. Lowering media pH from 7.4 to < or = 6.0 increased the release of CGRP-LI. Lactic acid (5 and 10 mM) by itself elevated CGRP-LI release from a control of 6.89 +/- 0.95 to 57.2 +/- 8.2 and 116 +/- 13 pg/mg protein, respectively. The combination of pH 6.0 and lactic acid (5 or 10 mM) caused more than additive stimulation of CGRP-LI release. BK (50 or 100 microM) elevated CGRP-LI release, which was greatly enhanced by lactic acid (2.5 or 5 mM). The data indicate that lactic acid potentiates BK- and low-pH-induced release of CGRP from sensory nerves in spinal cord. Similar mechanisms may occur at peripheral ends of sensory nerves, contributing to CGRP release during septic shock and other conditions with elevated lactic acid levels (e.g., strenuous exercise and tissue ischemia).

Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord

1991 ◽  
Vol 547 (2) ◽  
pp. 344-348 ◽  
Author(s):  
Danxia Liu ◽  
Wipawan Thangnipon ◽  
David J. McAdoo
Keyword(s):  
Amino Acids ◽  
Spinal Cord ◽  
Excitatory Amino Acids ◽  
Rat Spinal Cord ◽  
Impact Injury
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