CSF Phosphorylated Tau Protein and Mild Cognitive Impairment: A Prospective Study

2000 ◽  
Vol 166 (1) ◽  
pp. 201-203 ◽  
Author(s):  
Hiroyuki Arai ◽  
Koichi Ishiguro ◽  
Hideto Ohno ◽  
Michiko Moriyama ◽  
Nobuo Itoh ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Study ◽  
Tau Protein ◽  
Phosphorylated Tau ◽  
A Prospective Study ◽  
Phosphorylated Tau Protein

O5-04-05: Aerobic exercise reduces phosphorylated tau protein in cerebrospinal fluid in older adults with mild cognitive impairment

2015 ◽  
Vol 11 (7S_Part_7) ◽  
pp. P324-P324 ◽  
Author(s):  
Laura D. Baker ◽  
Jeannine S. Skinner ◽  
Suzanne Craft ◽  
Kaycee M. Sink ◽  
Thomas Montine ◽  
...  
Keyword(s):  
Older Adults ◽  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Aerobic Exercise ◽  
Tau Protein ◽  
Phosphorylated Tau ◽  
Phosphorylated Tau Protein

CSF APPsα and Phosphorylated Tau Protein Levels in Mild Cognitive Impairment and Dementia of Alzheimer's Type

2008 ◽  
Vol 22 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Andreas Fellgiebel ◽  
Elzbieta Kojro ◽  
Matthias J. Muller ◽  
Armin Scheurich ◽  
Lutz G. Schmidt ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Tau Protein ◽  
Phosphorylated Tau ◽  
Protein Levels ◽  
Dementia Of Alzheimer’S Type ◽  
Phosphorylated Tau Protein

scholarly journals Is cerebral microbleed prevalence relevant as a biomarker in amnestic mild cognitive impairment and mild Alzheimer’s disease?

2017 ◽  
Vol 30 (5) ◽  
pp. 477-485 ◽  
Author(s):  
Ana GB Rabelo ◽  
Camila VL Teixeira ◽  
Thamires NC Magalhães ◽  
Ana Flávia MK Carletti-Cassani ◽  
Augusto CS Amato Filho ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Apolipoprotein E ◽  
Tau Protein ◽  
Amnestic Mild Cognitive Impairment ◽  
Phosphorylated Tau ◽  
Phosphorylated Tau Protein ◽  
Age And Sex

Introduction The search for a reliable neuroimaging biomarker in Alzheimer’s disease is a matter of intense research. The presence of cerebral microbleeds seems to be a potential biomarker. However, it is not clear if the presence of microbleeds has clinical usefulness to differentiate mild Alzheimer’s disease and amnestic mild cognitive impairment from normal aging. We aimed to verify if microbleed prevalence differs among three groups: mild Alzheimer’s disease, amnestic mild cognitive impairment due to Alzheimer’s disease, and normal controls. Moreover, we studied whether microbleeds were associated with apolipoprotein E allele ɛ4 status, cerebrospinal fluid amyloid-beta, total and phosphorylated tau protein levels, vascular factors, and cognition. Methods Twenty-eight mild Alzheimer’s disease patients, 34 with amnestic mild cognitive impairment and 36 cognitively normal elderly subjects underwent: magnetic resonance imaging with a susceptibility-weighted imaging sequence on a 3T scanner, apolipoprotein E genotyping and a full neuropsychological evaluation. Only amnestic mild cognitive impairment and mild Alzheimer’s disease underwent cerebrospinal fluid analysis. We compared the groups and verified if microbleeds were predicted by all other variables. Results Mild Alzheimer’s disease presented a higher prevalence of apolipoprotein E allele ɛ4 in relation to amnestic mild cognitive impairment and control group. No significant differences were found between groups when considering microbleed presence. Logistic regression tests failed to find any relationship between microbleeds and the variables. We performed three different regression models using different independent variables: Model 1 - amyloid-beta, phosphorylated tau protein, total tau, apolipoprotein E allele ɛ4 status, age, and sex; Model 2 - vascular risk factors, age, and sex; Model 3 - cognitive scores sex, age, and education. Conclusion Although microbleeds might be related to the Alzheimer’s disease process, their presence is not a good candidate for a neuroimaging biomarker of the disease, especially in its early phases.

scholarly journals Magnetic resonance spectroscopy and brain volumetry in mild cognitive impairment. A prospective study

2017 ◽  
Vol 38 ◽  
pp. 27-32 ◽  
Author(s):  
Nicolás Fayed ◽  
Pedro J. Modrego ◽  
Gracián García-Martí ◽  
Roberto Sanz-Requena ◽  
Luis Marti-Bonmatí
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Prospective Study ◽  
Resonance Spectroscopy ◽  
Brain Volumetry ◽  
A Prospective Study

scholarly journals A Prospective Study of Chronic Obstructive Pulmonary Disease and the Risk for Mild Cognitive Impairment

2014 ◽  
Vol 71 (5) ◽  
pp. 581 ◽  
Author(s):  
Balwinder Singh ◽  
Michelle M. Mielke ◽  
Ajay K. Parsaik ◽  
Ruth H. Cha ◽  
Rosebud O. Roberts ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Study ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
A Prospective Study

Mild Cognitive Impairment, Slow Gait, and Risk of Disability: A Prospective Study

2015 ◽  
Vol 16 (12) ◽  
pp. 1082-1086 ◽  
Author(s):  
Takehiko Doi ◽  
Hiroyuki Shimada ◽  
Hyuma Makizako ◽  
Kota Tsutsumimoto ◽  
Ryo Hotta ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Study ◽  
A Prospective Study
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