scholarly journals Body mass index and mild cognitive impairment-to-dementia progression in 24 months: a prospective study

2014 ◽  
Vol 68 (11) ◽  
pp. 1216-1219 ◽  
Author(s):  
T Sobów ◽  
W Fendler ◽  
R Magierski
Keyword(s):  
Body Mass Index ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Study ◽  
Body Mass ◽  
A Prospective Study

Joint Effect of ABCA7 rs4147929 and Body Mass Index on Progression from Mild Cognitive Impairment to Alzheimer’s Disease: The Shanghai Aging Study

2020 ◽  
Vol 17 (2) ◽  
pp. 185-195
Author(s):  
Jianxiong Xi ◽  
Ding Ding ◽  
Qianhua Zhao ◽  
Xiaoniu Liang ◽  
Li Zheng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Body Mass ◽  
Joint Effect ◽  
Genome Wide Association Studies ◽  
Risk Genotype ◽  
Aging Study

Background: Approximately 40 independent Single Nucleotide Polymorphisms (SNPs) have been associated with Alzheimer’s Disease (AD) or cognitive decline in genome-wide association studies. Methods: We aimed to evaluate the joint effect of genetic polymorphisms and environmental factors on the progression from Mild Cognitive Impairment (MCI) to AD (MCI-AD progression) in a Chinese community cohort. Conclusion: Demographic, DNA and incident AD diagnosis data were derived from the follow-up of 316 participants with MCI at baseline of the Shanghai Aging Study. The associations of 40 SNPs and environmental predictors with MCI-AD progression were assessed using the Kaplan-Meier method with the log-rank test and Cox regression model. Results: Rs4147929 at ATP-binding cassette family A member 7 (ABCA7) (AG/AA vs. GG, hazard ratio [HR] = 2.43, 95% confidence interval [CI] 1.24-4.76) and body mass index (BMI) (overweight vs. non-overweight, HR = 0.41, 95% CI 0.22-0.78) were independent predictors of MCI-AD progression. In the combined analyses, MCI participants with the copresence of non-overweight BMI and the ABCA7 rs4147929 (AG/AA) risk genotype had an approximately 6-fold higher risk of MCI-AD progression than those with an overweight BMI and a non-risk genotype (HR = 6.77, 95% CI 2.60-17.63). However, a nonsignificant result was found when participants carried only one of these two risk factors (nonoverweight BMI and AG/AA of ABCA7 rs4147929). Conclusion: ABCA7 rs4147929 and BMI jointly affect MCI-AD progression. MCI participants with the rs4147929 risk genotype may benefit from maintaining an overweight BMI level with regard to their risk for incident AD.

scholarly journals Five-Year Change in Body Mass Index Predicts Conversion to Mild Cognitive Impairment or Dementia Only in APOE ɛ4 Allele Carriers

2021 ◽  
pp. 1-11
Author(s):  
Kylie R. Kadey ◽  
John L. Woodard ◽  
Allison C. Moll ◽  
Kristy A. Nielson ◽  
J. Carson Smith ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Mass Index ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Body Mass ◽  
Carrier Status ◽  
Healthy Older Adults ◽  
E4 Allele ◽  
Lifestyle Risk

Background: Body mass index (BMI) has been identified as an important modifiable lifestyle risk factor for dementia, but less is known about how BMI might interact with Apolipoprotein E ɛ4 (APOE ɛ4) carrier status to predict conversion to mild cognitive impairment (MCI) and dementia. Objective: The aim of this study was to investigate the interaction between APOE ɛ4 status and baseline (bBMI) and five-year BMI change (ΔBMI) on conversion to MCI or dementia in initially cognitively healthy older adults. Methods: The associations between bBMI, ΔBMI, APOE ɛ4 status, and conversion to MCI or dementia were investigated among 1,289 cognitively healthy elders from the National Alzheimer’s Coordinating Center (NACC) database. Results: After five years, significantly more carriers (30.6%) converted to MCI or dementia than noncarriers (17.6%), p <  0.001, OR = 2.06. Neither bBMI (OR = 0.99, 95%CI = 0.96–1.02) nor the bBMI by APOE interaction (OR = 1.02, 95%CI = 0.96–1.08) predicted conversion. Although ΔBMI also did not significantly predict conversion (OR = 0.90, 95%CI = 0.78–1.04), the interaction between ΔBMI and carrier status was significant (OR = 0.72, 95%CI = 0.53–0.98). For carriers only, each one-unit decline in BMI over five years was associated with a 27%increase in the odds of conversion (OR = 0.73, 95%CI = 0.57–0.94). Conclusion: A decline in BMI over five years, but not bBMI, was strongly associated with conversion to MCI or dementia only for APOE ɛ4 carriers. Interventions and behaviors aimed at maintaining body mass may be important for long term cognitive health in older adults at genetic risk for AD.

Postdiagnosis body mass index and risk of mortality in colorectal cancer survivors: a prospective study and meta-analysis

2014 ◽  
Vol 25 (10) ◽  
pp. 1407-1418 ◽  
Author(s):  
Sabrina Schlesinger ◽  
Sabine Siegert ◽  
Manja Koch ◽  
Jessica Walter ◽  
Nils Heits ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Prospective Study ◽  
Cancer Survivors ◽  
Body Mass ◽  
Meta Analysis ◽  
Colorectal Cancer Survivors ◽  
Risk Of Mortality ◽  
A Prospective Study

Contemporary antiretrovirals and body-mass index: a prospective study of the RESPOND cohort consortium

2021 ◽  
Author(s):  
Loveleen Bansi-Matharu ◽  
Andrew Phillips ◽  
Cristiana Oprea ◽  
Katharina Grabmeier-Pfistershammer ◽  
Huldrych F Günthard ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Prospective Study ◽  
Body Mass ◽  
A Prospective Study

A prospective study of body mass index and risk of spontaneous abortion

2013 ◽  
Vol 100 (3) ◽  
pp. S336
Author(s):  
K.A. Hahn ◽  
L.A. Wise ◽  
E.M. Mikkelsen ◽  
H.T. Sorensen ◽  
K.J. Rothman ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Prospective Study ◽  
Body Mass ◽  
Spontaneous Abortion ◽  
A Prospective Study

scholarly journals Body Mass Index and Serum γ‐glutamyltransferase Level as Risk Factors for Injuries Related to Professional Horse Racing: A Prospective Study

2009 ◽  
Vol 51 (4) ◽  
pp. 323-331 ◽  
Author(s):  
Hiroko Tobari ◽  
Kazumasa Yamagishi ◽  
Hiroyuki Noda ◽  
Takeshi Tanigawa ◽  
Hiroyasu Iso
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Prospective Study ◽  
Body Mass ◽  
Horse Racing ◽  
A Prospective Study

scholarly journals Body Mass Index, Weight Change, and Clinical Progression in Mild Cognitive Impairment and Alzheimer Disease

2014 ◽  
Vol 28 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Lilah M. Besser ◽  
Dawn P. Gill ◽  
Sarah E. Monsell ◽  
Willa Brenowitz ◽  
Dana H. Meranus ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer Disease ◽  
Body Mass ◽  
Weight Change ◽  
Clinical Progression ◽  
Index Weight

Family history, body mass index and survival in Japanese patients with stomach cancer: a prospective study

2014 ◽  
Vol 136 (2) ◽  
pp. 411-424 ◽  
Author(s):  
Yuko Minami ◽  
Masaaki Kawai ◽  
Tsuneaki Fujiya ◽  
Masaki Suzuki ◽  
Tetsuya Noguchi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Family History ◽  
Prospective Study ◽  
Stomach Cancer ◽  
Body Mass ◽  
Japanese Patients ◽  
A Prospective Study
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