Blood–Brain Barrier Disruption and Complement Activation in the Brain Following Rapid Correction of Chronic Hyponatremia

2000 ◽  
Vol 165 (2) ◽  
pp. 221-230 ◽  
Author(s):  
Erin A. Baker ◽  
Ying Tian ◽  
Sheldon Adler ◽  
Joseph G. Verbalis
Keyword(s):  
Blood Brain Barrier ◽  
Complement Activation ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Chronic Hyponatremia ◽  
Brain Barrier Disruption ◽  
The Brain ◽  
Rapid Correction

scholarly journals Increased nanoparticle-loaded exogenous macrophage migration into the brain following PDT-induced blood-brain barrier disruption

2013 ◽  
Vol 45 (8) ◽  
pp. 524-532 ◽  
Author(s):  
Steen J. Madsen ◽  
H. Michael Gach ◽  
Seok Jin Hong ◽  
Francisco A. Uzal ◽  
Qian Peng ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Macrophage Migration ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption ◽  
The Brain

Blood-brain barrier disruption in humans using an implantable ultrasound device: quantification with MR images and correlation with local acoustic pressure

2020 ◽  
Vol 132 (3) ◽  
pp. 875-883 ◽  
Author(s):  
Nicolas Asquier ◽  
Guillaume Bouchoux ◽  
Michael Canney ◽  
Cyril Martin ◽  
Bruno Law-Ye ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Acoustic Pressure ◽  
Brain Barrier ◽  
Mr Images ◽  
Barrier Disruption ◽  
Ultrasound Device ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption ◽  
The Brain

OBJECTIVEOne of the goals in this study was to set up a semiautomatic method to estimate blood-brain barrier disruption obtained in patients with glioblastoma by using an implantable, unfocused, ultrasound device. Another goal was to correlate the probability of significant ultrasound-induced signal enhancement (SUISE) with local acoustic pressure in the brain.METHODSGd-enhanced MR images acquired before and after ultrasound treatments were analyzed prospectively. The image sets were segmented, normalized, and coregistered to evaluate contrast enhancement. The volume of SUISE was calculated with voxels labeled as gray or white matter, in a cylindrical region of interest, and with enhancement above a given threshold. To validate the method, the resulting volumes of SUISE were compared to qualitative grades previously assigned by 3 clinicians for 40 ultrasound treatments in 15 patients. A parametric study was performed to optimize the algorithm prediction of the qualitative grades. The 3D acoustic field in the brain was estimated from measurements in water combined with simulations accounting for ultrasound attenuation in brain and overlaid on each MR image to correlate local acoustic pressure with the probability of SUISE (defined as enhancement > 10%).RESULTSThe algorithm predicted grade 2 or 3 and grade 3 openings with areas under the receiver operating characteristic curve of 0.831 and 0.995, respectively. The probability of SUISE was correlated with local acoustic pressure (R2 = 0.98) and was 3.33 times higher for gray matter than for white matter.CONCLUSIONSAn algorithm for evaluating blood-brain barrier disruption was validated and can be used for future clinical trials to further understand and quantify this technique in humans.Clinical trial registration no.: NCT02253212 (clinicaltrials.gov)

Positive association between blood brain barrier disruption and osmotically-induced demyelination

2000 ◽  
Vol 6 (1) ◽  
pp. 24-31 ◽  
Author(s):  
S Adler ◽  
J Martinez ◽  
D S Williams ◽  
J G Verbalis
Keyword(s):  
Blood Brain Barrier ◽  
Strong Association ◽  
Positive Association ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Chronic Hyponatremia ◽  
Brain Barrier Disruption

Rapid correction of chronic hyponatremia can cause osmotic brain demyelination in animals and humans. Why demyelination develops is unknown, but blood brain-barrier disruption might expose oligodendrocytes to substances normally excluded from the brain. To test this hypothesis, chronic hyponatremia was induced and corrected using a new, reproducible rat model for producing osmotic brain demyelination. Blood brain barrier integrity was assessed by NMR imaging at either 3, 16 or 24 h during the first day of correction. Demyelination was determined histopathologically 5-6 days later. Of 96 rats studied, demyelination developed 5-6 days later in 37 rats, 89% of whom showed barrier disruption. In the 59 rats who did not develop demyelination, 45 (76%) had no barrier disruption. Thus, blood-brain barrier disruption during the first 24 h of correction was associated with a 70% risk of developing demyelination. By contrast, the risk of developing subsequent demyelination was only 8% when the barrier was intact. This strong association between barrier disruption and subsequent demyelination provides new insights into the role of blood brain barrier function in demyelinative disorders such as the osmotic demyelination syndrome and by extension to other demyelinative disorders such as multiple sclerosis.

scholarly journals Lycium barbarum Extracts Protect the Brain from Blood-Brain Barrier Disruption and Cerebral Edema in Experimental Stroke

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e33596 ◽  
Author(s):  
Di Yang ◽  
Suk-Yee Li ◽  
Chung-Man Yeung ◽  
Raymond Chuen-Chung Chang ◽  
Kwok-Fai So ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Cerebral Edema ◽  
Brain Barrier ◽  
Experimental Stroke ◽  
Lycium Barbarum ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption ◽  
The Brain

CNS-irrelevant T-cells enter the brain, cause blood-brain barrier disruption but no glial pathology

2007 ◽  
Vol 26 (6) ◽  
pp. 1387-1398 ◽  
Author(s):  
Alina Smorodchenko ◽  
Jens Wuerfel ◽  
Elena E. Pohl ◽  
Johannes Vogt ◽  
Eva Tysiak ◽  
...  
Keyword(s):  
T Cells ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption ◽  
The Brain
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