scholarly journals Increased nanoparticle-loaded exogenous macrophage migration into the brain following PDT-induced blood-brain barrier disruption

2013 ◽  
Vol 45 (8) ◽  
pp. 524-532 ◽  
Author(s):  
Steen J. Madsen ◽  
H. Michael Gach ◽  
Seok Jin Hong ◽  
Francisco A. Uzal ◽  
Qian Peng ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Macrophage Migration ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption ◽  
The Brain

Blood-brain barrier disruption in humans using an implantable ultrasound device: quantification with MR images and correlation with local acoustic pressure

2020 ◽  
Vol 132 (3) ◽  
pp. 875-883 ◽  
Author(s):  
Nicolas Asquier ◽  
Guillaume Bouchoux ◽  
Michael Canney ◽  
Cyril Martin ◽  
Bruno Law-Ye ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Acoustic Pressure ◽  
Brain Barrier ◽  
Mr Images ◽  
Barrier Disruption ◽  
Ultrasound Device ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption ◽  
The Brain

OBJECTIVEOne of the goals in this study was to set up a semiautomatic method to estimate blood-brain barrier disruption obtained in patients with glioblastoma by using an implantable, unfocused, ultrasound device. Another goal was to correlate the probability of significant ultrasound-induced signal enhancement (SUISE) with local acoustic pressure in the brain.METHODSGd-enhanced MR images acquired before and after ultrasound treatments were analyzed prospectively. The image sets were segmented, normalized, and coregistered to evaluate contrast enhancement. The volume of SUISE was calculated with voxels labeled as gray or white matter, in a cylindrical region of interest, and with enhancement above a given threshold. To validate the method, the resulting volumes of SUISE were compared to qualitative grades previously assigned by 3 clinicians for 40 ultrasound treatments in 15 patients. A parametric study was performed to optimize the algorithm prediction of the qualitative grades. The 3D acoustic field in the brain was estimated from measurements in water combined with simulations accounting for ultrasound attenuation in brain and overlaid on each MR image to correlate local acoustic pressure with the probability of SUISE (defined as enhancement > 10%).RESULTSThe algorithm predicted grade 2 or 3 and grade 3 openings with areas under the receiver operating characteristic curve of 0.831 and 0.995, respectively. The probability of SUISE was correlated with local acoustic pressure (R2 = 0.98) and was 3.33 times higher for gray matter than for white matter.CONCLUSIONSAn algorithm for evaluating blood-brain barrier disruption was validated and can be used for future clinical trials to further understand and quantify this technique in humans.Clinical trial registration no.: NCT02253212 (clinicaltrials.gov)

scholarly journals Lycium barbarum Extracts Protect the Brain from Blood-Brain Barrier Disruption and Cerebral Edema in Experimental Stroke

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e33596 ◽  
Author(s):  
Di Yang ◽  
Suk-Yee Li ◽  
Chung-Man Yeung ◽  
Raymond Chuen-Chung Chang ◽  
Kwok-Fai So ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Cerebral Edema ◽  
Brain Barrier ◽  
Experimental Stroke ◽  
Lycium Barbarum ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption ◽  
The Brain

CNS-irrelevant T-cells enter the brain, cause blood-brain barrier disruption but no glial pathology

2007 ◽  
Vol 26 (6) ◽  
pp. 1387-1398 ◽  
Author(s):  
Alina Smorodchenko ◽  
Jens Wuerfel ◽  
Elena E. Pohl ◽  
Johannes Vogt ◽  
Eva Tysiak ◽  
...  
Keyword(s):  
T Cells ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption ◽  
The Brain

The treatment of brain metastasis from breast cancer, role of blood-brain barrier disruption and early experience with trastuzumab

Therapy ◽  
2006 ◽  
Vol 3 (1) ◽  
pp. 97-112 ◽  
Author(s):  
Rose Marie Tyson ◽  
Dale F Kraemer ◽  
Matthew A Hunt ◽  
Leslie L Muldoon ◽  
Peter Orbay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Blood Brain Barrier ◽  
Early Experience ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption
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