Apoptotic Cell Death in the Mouse Retinal Ganglion Cell Layer is Induced in vivo by the Excitatory Amino Acid Homocysteine

2001 ◽  
Vol 73 (1) ◽  
pp. 45-57 ◽  
Author(s):  
Pamela Moore ◽  
Amira El-sherbeny ◽  
Penny Roon ◽  
Patricia V Schoenlein ◽  
Vadivel Ganapathy ◽  
...  
Keyword(s):  
Cell Death ◽  
Amino Acid ◽  
Ganglion Cell ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Excitatory Amino Acid ◽  
Apoptotic Cell ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Layer

scholarly journals Improvements to multi-offset adaptive optics scanning laser ophthalmoscopy for in vivo imaging of individual retinal ganglion cell layer neurons in humans

2020 ◽  
Author(s):  
Elena Gofas-Salas ◽  
Yuhua Rui ◽  
Pedro Mecê ◽  
Min Zhang ◽  
Valerie C. Snyder ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Adaptive Optics ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Scanning Laser ◽  
Retinal Ganglion ◽  
Detection Scheme ◽  
Retinal Ganglion Cell Layer

AbstractRetinal ganglion cells (RGCs) are the primary output neurons of the retina. RGC dysfunction and death can cause irreversible vision loss in glaucoma and other ocular diseases. However, no methods exist to evaluate RGCs at the level of single cell in the living human eye in the clinic. Our aim is to implement a technique revealing the retinal ganglion cell layer neurons whose contrast, robustness and acquisition time would make it suitable for clinical diagnosis and monitoring of patients. While previously we were able to demonstrate high contrast imaging in monkeys, here we propose a new adaptive optics scanning laser ophthalmoscope configuration that allows us to achieve similar results on humans in vivo. In particular we used a new detection scheme that allowed us to switch from two light sources to one thereby enabling us to increase the light power, eliminate problems caused by chromatic aberration and improve the image registration process. Here we show that this optimized detection scheme and image processing pipeline improve the multi-offset technique for imaging of human RGC layer neurons.

Age-Dependent Susceptibility of the Retinal Ganglion Cell Layer to Cell Death

2006 ◽  
Vol 47 (3) ◽  
pp. 807 ◽  
Author(s):  
Declan P. McKernan ◽  
Ciara Caplis ◽  
Maryanne Donovan ◽  
Colm J. O’Brien ◽  
Thomas G. Cotter
Keyword(s):  
Cell Death ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Layer ◽  
Age Dependent

scholarly journals 17β-Estradiol Eye Drops Protect the Retinal Ganglion Cell Layer and Preserve Visual Function in an in Vivo Model of Glaucoma

2013 ◽  
Vol 10 (8) ◽  
pp. 3253-3261 ◽  
Author(s):  
Katalin Prokai-Tatrai ◽  
Hua Xin ◽  
Vien Nguyen ◽  
Szabolcs Szarka ◽  
Balazs Blazics ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Visual Function ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
In Vivo Model ◽  
Eye Drops ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Layer ◽  
17Β Estradiol

Long-Term Effect of Optic Nerve Axotomy on the Retinal Ganglion Cell Layer

2015 ◽  
Vol 56 (10) ◽  
pp. 6095 ◽  
Author(s):  
Francisco M. Nadal-Nicolás ◽  
Paloma Sobrado-Calvo ◽  
Manuel Jiménez-López ◽  
Manuel Vidal-Sanz ◽  
Marta Agudo-Barriuso
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Term Effect ◽  
Retinal Ganglion ◽  
Long Term Effect ◽  
Retinal Ganglion Cell Layer
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