Effect of Sorbitol Dehydrogenase Inhibition on Sugar Cataract Formation in Galactose-fed and Diabetic Rats

1998 ◽  
Vol 67 (2) ◽  
pp. 203-208 ◽  
Author(s):  
PETER F. KADOR ◽  
JUN INOUE ◽  
E.FILLIPO SECCHI ◽  
MARTIN J. LIZAK ◽  
LIBANIEL RODRIGUEZ ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Sorbitol Dehydrogenase ◽  
Cataract Formation ◽  
Sugar Cataract

scholarly journals Glycation and inactivation of sorbitol dehydrogenase in normal and diabetic rats

1996 ◽  
Vol 318 (1) ◽  
pp. 119-123 ◽  
Author(s):  
Ayumu HOSHI ◽  
Motoko TAKAHASHI ◽  
Junichi FUJII ◽  
Theingi MYINT ◽  
Hideaki KANETO ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Diabetic Complications ◽  
Polyol Pathway ◽  
Diabetic Rats ◽  
Sorbitol Dehydrogenase ◽  
Enzyme Content ◽  
Glycated Protein ◽  
Liver And Kidney

Sorbitol dehydrogenase (SDH) is involved in the polyol pathway, which plays an important role in the pathogenesis of diabetic complications. We have measured the tissue distributions of SDH mRNA, both the immunoreactive enzyme levels and the enzyme activity. SDH mRNA was especially abundant in liver, kidney and testis. Both the activity and enzyme content are high in liver and kidney but not in testis. The discrepancy between mRNA and immunoreactive enzyme levels and the activity of SDH observed in testis was also seen in livers of streptozotocin-induced diabetic rats. SDH was found to exist in both glycated and non-glycated forms, with larger amounts of the glycated protein in the diabetic liver. Moreover, after incubation of purified enzyme with glucose or fructose, its activity was markedly decreased. These results indicate that glycation causes a decrease in SDH activity in liver under diabetic conditions. The same post-transcriptional event might occur to decrease the activity of SDH in testis in normal animals.

The effect of an unsaturated-fat diet on cataract formation in streptozotocin-induced diabetic rats

1976 ◽  
Vol 36 (02) ◽  
pp. 161 ◽  
Author(s):  
J. C. Hutton ◽  
P. J. Schofield ◽  
J. F. Williams ◽  
H. L. Regtop ◽  
F. C. Hollows
Keyword(s):  
Diabetic Rats ◽  
Cataract Formation ◽  
Unsaturated Fat

Inhibitory Effect of Astraxanthin Combined with Flavangenol® on Oxidative Stress Biomarkers in Streptozotocin-Iduced Diabetic Rats

2008 ◽  
Vol 78 (45) ◽  
pp. 175-182 ◽  
Author(s):  
Masako Nakano ◽  
Natsumi Orimo ◽  
Nakako Katagiri ◽  
Masahito Tsubata ◽  
Jiro Takahashi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxide ◽  
Inhibitory Effect ◽  
Diabetic Rats ◽  
Control Group ◽  
Cataract Formation ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Liver And Kidney ◽  
Streptozotocin Induced Diabetes

In this study, the effect of dietary antioxidants, such as astaxanthin and Flavangenol®, and a combination of both, in counteracting oxidative stress in streptozotocin-induced diabetes was investigated. Streptozotocin-induced diabetic rats were divided into four groups: control, astaxanthin, Flavangenol, and combined astaxanthin and Flavangenol (mix group). Each group other than the control group was fed with an astaxanthin diet (0.1 g/kg), Flavangenol diet (2.0 g/kg), or an astaxanthin (0.1 g/kg)-Flavangenol (2.0 g/kg) mixture diet, respectively. After 12 weeks of feeding, the results showed that the lipid peroxide levels of plasma and lens and the plasma triglyceride (TG) level in the mix group were significantly decreased by 44%, 20%, and 20%, respectively, compared with the control group. In the mix group, lipid peroxidation was also significantly reduced by 70% in the liver and 20% in the kidney compared with the control group. Furthermore, the level of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the mix group was significantly lower, 36%, than the control group. The α-tocopherol concentrations in the plasma, liver, and kidney in the astaxanthin and mix groups were significantly higher, 3-9 times, than in the control group. The degree of cataract formation in the Flavangenol and mix groups tended to be lower than the control group. These results indicate that the combination of astaxanthin with Flvangenol has an improved protective effect on oxidative stress associated with streptozotocin-induced diabetes than either agent used alone. Thus, this combination may be beneficial in preventing the progression of diabetic complications.

The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis)

2001 ◽  
Vol 130-132 ◽  
pp. 617-625 ◽  
Author(s):  
Masatoshi Murata ◽  
Nobuo Ohta ◽  
Shinichi Sakurai ◽  
Shahabuddin Alam ◽  
Jen-Yue Tsai ◽  
...  
Keyword(s):  
Cell Death ◽  
Epithelial Cell ◽  
Aldose Reductase ◽  
Lens Epithelial Cell ◽  
Cataract Formation ◽  
Sugar Cataract ◽  
Epithelial Cell Death

Cataract Formation Is Prevented by Administration of Verapamil to Diabetic Rats*

Endocrinology ◽  
1989 ◽  
Vol 125 (2) ◽  
pp. 730-735 ◽  
Author(s):  
GRANT N. PIERCE ◽  
NASIR AFZAL ◽  
EDWIN A. KROEGER ◽  
M. KATHERINE LOCKWOOD ◽  
MICHAEL J. B. KUTRYK ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Cataract Formation

scholarly journals Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation

2012 ◽  
Vol 101 ◽  
pp. 36-43 ◽  
Author(s):  
Peng Zhang ◽  
Kuiyi Xing ◽  
James Randazzo ◽  
Karen Blessing ◽  
Marjorie F. Lou ◽  
...  
Keyword(s):  
Growth Factors ◽  
Osmotic Stress ◽  
Aldose Reductase ◽  
Reductase Activity ◽  
Mapk Signaling ◽  
Cataract Formation ◽  
Sugar Cataract

The effect of aldose reductase and its inhibition on sugar cataract formation

Metabolism ◽  
1986 ◽  
Vol 35 (4) ◽  
pp. 15-19 ◽  
Author(s):  
Peter F. Kador ◽  
Yoshio Akagi ◽  
Jin H. Kinoshita
Keyword(s):  
Aldose Reductase ◽  
Cataract Formation ◽  
Sugar Cataract

The role of lens epithelium in sugar cataract formation

1990 ◽  
Vol 50 (6) ◽  
pp. 641-646 ◽  
Author(s):  
W.Gerald Robison ◽  
Nancy Houlder ◽  
Jin H. Kinoshita
Keyword(s):  
Lens Epithelium ◽  
Cataract Formation ◽  
Sugar Cataract

Therapeutic effects of various renin angiotensin modulators on hyperglycemia-induced cataract formation in Sprague Dawley rats

2020 ◽  
pp. 112067212096240
Author(s):  
Jaya Shree ◽  
Rajesh Choudhary ◽  
Surendra H Bodakhe
Keyword(s):  
Single Dose ◽  
Angiotensin Receptor Blockers ◽  
Research Work ◽  
Topical Administration ◽  
Diabetic Rats ◽  
Therapeutic Effects ◽  
Cataract Formation ◽  
Sprague Dawley ◽  
Citrate Buffer ◽  
Renin Angiotensin

Objects: Our previous research work reported the beneficial effects of angiotensin receptor blockers (ARBs) for the treatment of diabetes associated cataract which was induced by streptozotocin (STZ). The current study, evaluated the effects of topical administration of various renin angiotensin modulators on STZ-induced cataracts in rats. Methods: Single dose of STZ (60 mg/kg, i.p.) was administered in the rats to induce diabetes. Animals were divided into normal and diabetic rats. Normal rats were administered with single dose of sodium citrate buffer (0.1 M, 10ml/kg, i.p.). Diabetic animals were divided into various treatment groups, each group contains six animals and received aliskiren, olmesartan, enalapril, and angiotensin 1–7 at a dose of 0.5% w/v topically on the cornea of the eye for a period of 8 weeks. During experimental protocol morphology of the eyes and lenticular opacity were monitored. Animals were sacrificed after 8 weeks of drug treatment, and various cataractogenic biochemical parameters were assessed. Results: Topical administrations with aliskiren, enalapril, olmesartan, and angiotensin 1–7 showed non-significant alterations in the blood glucose level, but significantly decreased lenticular opacity, restored antioxidant level, restored MDA level and Nitrite content, and decreased the onset of cataract formation. Conclusion: Overall, our findings suggest that topical treatment with renin angiotensin modulators delayed the onset of diabetes-induced cataract formation.

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