Inhibition of p38 MAP Kinase Activity Up-Regulates Multiple MAP Kinase Pathways and Potentiates 1,25-Dihydroxyvitamin D3-Induced Differentiation of Human Leukemia HL60 Cells

2000 ◽  
Vol 258 (2) ◽  
pp. 425-437 ◽  
Author(s):  
Xuening Wang ◽  
Jie Rao ◽  
George P. Studzinski
Keyword(s):  
Map Kinase ◽  
Kinase Activity ◽  
P38 Map Kinase ◽  
Human Leukemia ◽  
Induced Differentiation ◽  
Dihydroxyvitamin D3 ◽  
Hl60 Cells ◽  
1,25 Dihydroxyvitamin D3 ◽  
Map Kinase Pathways

Resistance to 1,25-dihydroxyvitamin D3 of a deoxycytidine kinase-deficient variant of human leukemia HL60 cells

1992 ◽  
Vol 203 (1) ◽  
pp. 244-250 ◽  
Author(s):  
Hui-min Xu ◽  
Sarah S. Kolla ◽  
Neil A. Goldenberg ◽  
George P. Studzinski
Keyword(s):  
Deoxycytidine Kinase ◽  
Human Leukemia ◽  
Dihydroxyvitamin D3 ◽  
Hl60 Cells ◽  
1,25 Dihydroxyvitamin D3

ERK and p38 MAP kinase are involved in arachidonic acid release induced by H2O2 and PDGF in mesangial cells

2002 ◽  
Vol 282 (3) ◽  
pp. F485-F491 ◽  
Author(s):  
Misako Hayama ◽  
Risa Inoue ◽  
Satoshi Akiba ◽  
Takashi Sato
Keyword(s):  
Arachidonic Acid ◽  
Map Kinase ◽  
Mesangial Cells ◽  
P38 Map Kinase ◽  
Arachidonic Acid Release ◽  
Cytosolic Phospholipase ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Acid Release ◽  
Map Kinase Pathways

Increased prostaglandin production is implicated in the pathogenesis of glomerular disease. With this consideration, we examined the combined effects of reactive oxygen species and platelet-derived growth factor (PDGF), which might initiate glomerular dysfunction, on arachidonic acid release and cytosolic phospholipase A2 (cPLA2) activation in rat mesangial cells. H2O2-induced release of arachidonic acid was enhanced by PDGF, which by itself had little effect on the release, and the enhancement was completely inhibited by a cPLA2 inhibitor. The phosphorylation of cPLA2, extracellular signal-regulated kinase (ERK), and p38 mitogen-activated protein (MAP) kinase was upregulated by H2O2 or PDGF alone and except for ERK was enhanced further by the two in combination. The release of arachidonic acid induced by PDGF together with H2O2 was inhibited partially by an inhibitor of ERK or p38 MAP kinase and completely when the two inhibitors were combined; the inhibitory pattern was similar to that for the phosphorylation of cPLA2. These results suggest that the ERK and p38 MAP kinase pathways are involved in the increase in cPLA2activation and arachidonic acid release induced by PDGF together with H2O2.

scholarly journals Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways

Leukemia ◽  
2010 ◽  
Vol 24 (4) ◽  
pp. 843-850 ◽  
Author(s):  
T Kobayashi ◽  
J Kuroda ◽  
E Ashihara ◽  
S Oomizu ◽  
Y Terui ◽  
...  
Keyword(s):  
Map Kinase ◽  
P38 Map Kinase ◽  
Map Kinase Pathways
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