scholarly journals Growth Arrest Specific Gene 1 Is a Positive Growth Regulator for the Cerebellum

2001 ◽  
Vol 236 (1) ◽  
pp. 30-45 ◽  
Author(s):  
Ying Liu ◽  
Noah R May ◽  
Chen-Ming Fan
Keyword(s):  
Growth Regulator ◽  
Growth Arrest ◽  
Specific Gene ◽  
Positive Growth

scholarly journals Growth arrest-specific gene 6 (Gas6) levels are elevated in patients with chronic renal failure

2012 ◽  
Vol 27 (11) ◽  
pp. 4166-4172 ◽  
Author(s):  
I. J. Lee ◽  
B. Hilliard ◽  
A. Swami ◽  
J. C. Madara ◽  
S. Rao ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Arrest ◽  
Specific Gene

Repression of a G0-associated 65-kilodalton protein in actively proliferating and SV40-transformed mouse kidney cells

1992 ◽  
Vol 70 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Timothy M. Rose ◽  
Sandra Tremblay ◽  
Edward W. Khandjian
Keyword(s):  
Primary Cultures ◽  
Growth Arrest ◽  
Mouse Kidney ◽  
Specific Gene ◽  
Nuclear Fraction ◽  
Quiescent State ◽  
Kidney Cells ◽  
Experimental Conditions ◽  
Two Dimensional Gel Electrophoresis ◽  
Mouse Cells

The pattern of [35S]methionine-labeled proteins from primary cultures of mouse kidney epithelial cells arrested in G0 phase was analyzed by two-dimensional gel electrophoresis and compared with that observed from cultures of actively proliferating and SV40-transformed mouse kidney cells. A major polypeptide (p65) migrating with a molecular mass of 65 000 daltons and a pI of 5.8 was detected in quiescent cultures of cells which had exhausted their finite division potential. Under the experimental conditions used, these cells had lost sensitivity to growth factors and were irreversibly blocked in G0 phase of the cell cycle. In cultures of actively proliferating mouse kidney cells, the expression of p65 was not observed until just prior to arrest. Moreover, proliferating cultures of immortalized mouse kidney cells that had been reactivated from their quiescent state by infection with SV40 did not express p65. Subcellular localization studies suggest that p65 is associated with the crude nuclear fraction. In addition, p65 is glycosylated and binds the lectin concanavalin A. Pulse–chase experiments demonstrated that p65 was short lived with an estimated half life of 10 min. Thus, p65 appears to be a growth-arrest specific gene product whose expression is repressed during the proliferative state of mitotically active mouse kidney cells.Key words: G0 phase, senescence, proliferation, quiescence, SV40-transformed mouse cells.

Axon-regulated expression of a Schwann cell transcript that is homologous to a ‘growth arrest-specific’ gene.

1991 ◽  
Vol 10 (12) ◽  
pp. 3661-3668 ◽  
Author(s):  
P. Spreyer ◽  
G. Kuhn ◽  
C.O. Hanemann ◽  
C. Gillen ◽  
H. Schaal ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Growth Arrest ◽  
Specific Gene ◽  
Regulated Expression

Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6

Nature ◽  
1995 ◽  
Vol 373 (6515) ◽  
pp. 623-626 ◽  
Author(s):  
Brian C. Varnum ◽  
Cynthia Young ◽  
Gary Elliott ◽  
Andy Garcia ◽  
Timothy D. Bartley ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Vitamin K ◽  
Receptor Tyrosine Kinase ◽  
Growth Arrest ◽  
Specific Gene ◽  
Dependent Protein ◽  
Axl Receptor Tyrosine Kinase

scholarly journals Role of Growth Arrest–Specific Gene 6 in the Development of Fungal Allergic Airway Disease in Mice

2014 ◽  
Vol 51 (5) ◽  
pp. 615-625 ◽  
Author(s):  
Takehiko Shibata ◽  
Ugur Burcin Ismailoglu ◽  
Nicolai A. Kittan ◽  
Ana Paula Moreira ◽  
Ana Lucia Coelho ◽  
...  
Keyword(s):  
Growth Arrest ◽  
Airway Disease ◽  
Allergic Airway Disease ◽  
Specific Gene

Expression of a growth arrest specific gene (gas-6) during liver regeneration: Molecular mechanisms and signalling pathways

1994 ◽  
Vol 158 (2) ◽  
pp. 263-269 ◽  
Author(s):  
Marina Ferrero ◽  
Maria Alfonsina Desiderio ◽  
Alessia Martinotti ◽  
Cecilia Melani ◽  
Aldo Bernelli-Zazzera ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Molecular Mechanisms ◽  
Growth Arrest ◽  
Signalling Pathways ◽  
Specific Gene

Localization of the human growth arrest-specific gene ( GAS1 ) to chromosome bands 9q21.3-q22, a region frequently deleted in myeloid malignancies

Genomics ◽  
1993 ◽  
Vol 18 (3) ◽  
pp. 731-733 ◽  
Author(s):  
Andreas Evdokiou ◽  
Graham C. Webb ◽  
Gregory B. Peters ◽  
Alexander Dobrovic ◽  
Denise S. O'Keefe ◽  
...  
Keyword(s):  
Growth Arrest ◽  
Human Growth ◽  
Specific Gene ◽  
Myeloid Malignancies ◽  
Chromosome Bands
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