scholarly journals Essential Roles of Retinoic Acid Signaling in Interdigital Apoptosis and Control of BMP-7 Expression in Mouse Autopods

1999 ◽  
Vol 208 (1) ◽  
pp. 30-43 ◽  
Author(s):  
Valérie Dupé ◽  
Norbert B. Ghyselinck ◽  
Vilmos Thomazy ◽  
László Nagy ◽  
Peter J.A. Davies ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Signaling ◽  
And Control

scholarly journals IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell–iTreg cell balance

2015 ◽  
Vol 16 (3) ◽  
pp. 286-295 ◽  
Author(s):  
Rajatava Basu ◽  
Sarah K Whitley ◽  
Suniti Bhaumik ◽  
Carlene L Zindl ◽  
Trenton R Schoeb ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Retinoic Acid ◽  
Th17 Cell ◽  
Retinoic Acid Signaling ◽  
Itreg Cell ◽  
Cell Balance ◽  
And Control

scholarly journals Aberrant regulation of retinoic acid signaling genes in cerebral arterio venous malformation nidus and neighboring astrocytes

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Jaya Mary Thomas ◽  
Dhakshmi Sasankan ◽  
Sumi Surendran ◽  
Mathew Abraham ◽  
Arumugam Rajavelu ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Rna Sequencing ◽  
Expression Pattern ◽  
Molecular Mechanisms ◽  
Venous Malformation ◽  
Immunofluorescence Staining ◽  
Sequencing Analysis ◽  
Retinoic Acid Signaling ◽  
Permanent Disability ◽  
And Control

Abstract Background Cerebral arterio venous malformations (AVM) are a major causal factor for intracranial hemorrhage, which result in permanent disability or death. The molecular mechanisms of AVM are complex, and their pathogenesis remains an enigma. Current research on cerebral AVM is focused on characterizing the molecular features of AVM nidus to elucidate the aberrant signaling pathways. The initial stimuli that lead to the development of AVM nidus structures between a dilated artery and a vein are however not known. Methods In order to understand the molecular basis of development of cerebral AVM, we used in-depth RNA sequencing with the total RNA isolated from cerebral AVM nidus. Immunoblot and qRT-PCR assays were used to study the differential gene expression in AVM nidus, and immunofluorescence staining was used to study the expression pattern of aberrant proteins in AVM nidus and control tissues. Immunohistochemistry was used to study the expression pattern of aberrant proteins in AVM nidus and control tissues. Results The transcriptome study has identified 38 differentially expressed genes in cerebral AVM nidus, of which 35 genes were upregulated and 3 genes were downregulated. A final modular analysis identified an upregulation of ALDH1A2, a key rate-limiting enzyme of retinoic acid signaling pathway. Further analysis revealed that CYR61, a regulator of angiogenesis, and the target gene for retinoic acid signaling is upregulated in AVM nidus. We observed that astrocytes associated with AVM nidus are abnormal with increased expression of GFAP and Vimentin. Triple immunofluorescence staining of the AVM nidus revealed that CYR61 was also overexpressed in the abnormal astrocytes associated with AVM tissue. Conclusion Using high-throughput RNA sequencing analysis and immunostaining, we report deregulated expression of retinoic acid signaling genes in AVM nidus and its associated astrocytes and speculate that this might trigger the abnormal angiogenesis and the development of cerebral AVM in humans.

scholarly journals GABAergic differentiation in the basal ganglia requires retinoic acid signaling

2011 ◽  
Vol 356 (1) ◽  
pp. 181
Author(s):  
Christina Chatzi ◽  
Thomas Brade ◽  
Gregg Duester
Keyword(s):  
Retinoic Acid ◽  
Basal Ganglia ◽  
Retinoic Acid Signaling

scholarly journals Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling

2017 ◽  
Vol 37 (10) ◽  
pp. 2565-2579 ◽  
Author(s):  
Jonathan J. Wilde ◽  
Julie A. Siegenthaler ◽  
Sharon Y.R. Dent ◽  
Lee A. Niswander
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Signaling ◽  
Acetyltransferase Activity
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