Rat Liver Preservation by Hypothermic Oscillating Liver Perfusion Compared to Simple Cold Storage

Cryobiology ◽  
1998 ◽  
Vol 36 (1) ◽  
pp. 61-70 ◽  
Author(s):  
P. Dutkowski ◽  
S. Schönfeld ◽  
B. Odermatt ◽  
T. Heinrich ◽  
T. Junginger
Keyword(s):  
Rat Liver ◽  
Cold Storage ◽  
Liver Perfusion ◽  
Liver Preservation

scholarly journals Euro-Collins Solution Versus Uw-Solution for Long-Term Liver Preservation in the Isolated Rat-Liver Perfusion Model

HPB Surgery ◽  
1991 ◽  
Vol 4 (4) ◽  
pp. 313-320 ◽  
Author(s):  
René Den Toom ◽  
Marion De Jong ◽  
Eric P. Krenning ◽  
Hans J. Van Der Hoek ◽  
Fiebo J. W. Ten Kate ◽  
...  
Keyword(s):  
Rat Liver ◽  
Cold Storage ◽  
Liver Perfusion ◽  
Ringer Solution ◽  
Metabolic Capacity ◽  
Liver Preservation ◽  
Uw Solution ◽  
Rat Liver Perfusion ◽  
Perfusion Period

To compare UW-solution (UW) and Euro-Collins (EC) for long-term liver preservation we investigated the morphology and metabolic capacity of rat liver after 18 and 42-hours cold-storage in either UW or EC.After harvesting the rat liver was transferred to a perfusion chamber where it was perfused for 10 min with UW or EC at 4°C. Thereafter livers were stored at 4°C in UW or EC for 18 hours (both groups n = 6) or for 42 hours (both groups n = 8). After 18-hr or 42-hr cold-storage a 2-hr warm perfusion (37°C) was started with Krebs-Ringer solution with carbogen to which 125Iodine-triiodothyronine (T3) was added. Control livers (n = 8) were immediately perfused with Krebs-Ringer without cold-storage. The following parameters were assessed: ASAT-levels in the perfusate, T3-metabolites in the bile and the perfusate, the perfusion pressure, the volume of bile secreted and light-microscopical morphology at the end of the warm perfusion period.After cold storage in UW-solution the ASAT-levels in the perfusate were lower than after storage in EC as well as the perfusion pressures. These livers demonstrated a better T3-metabolism and secreted more bile than EC-stored livers. Histological examination showed more tissue damage in the EC-stored livers than in the UW stored livers.We conclude that cold-storage of rat liver in UW-solution resulted in a better morphology and metabolic capacity as compared with EC-solution.

Evaluation of celsior solution in experimental liver preservation using ex situ isolated rat liver perfusion

1999 ◽  
Vol 31 (6) ◽  
pp. 2437-2438 ◽  
Author(s):  
P Cascales ◽  
V Fernández-Cornejo ◽  
F Sanchez-Del Campo ◽  
M de Torre ◽  
M.R Sanchez-Eixeres ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Perfusion ◽  
Ex Situ ◽  
Liver Preservation ◽  
Isolated Rat Liver ◽  
Rat Liver Perfusion ◽  
Experimental Liver ◽  
Isolated Rat

Effect of fructose-1,6-bisphosphate in the cold storage solution after 12 and 36 hours of rat liver preservation

2004 ◽  
Vol 36 (9) ◽  
pp. 2593-2595 ◽  
Author(s):  
R.N. Moresco ◽  
R.C.V. Santos ◽  
J.C.F. Alves Filho ◽  
J.R. De Oliveira
Keyword(s):  
Rat Liver ◽  
Cold Storage ◽  
Liver Preservation ◽  
Fructose 1,6 Bisphosphate ◽  
Storage Solution

scholarly journals Alterations of lysosomal size and density during rat liver perfusion. Suppression by insulin and amino acids.

1977 ◽  
Vol 252 (19) ◽  
pp. 6948-6954 ◽  
Author(s):  
A N Neely ◽  
J R Cox ◽  
J A Fortney ◽  
C M Schworer ◽  
G E Mortimore
Keyword(s):  
Amino Acids ◽  
Rat Liver ◽  
Liver Perfusion ◽  
Rat Liver Perfusion

A flowmeter for use in monitoring oxygen uptake in rat liver perfusion

1967 ◽  
Vol 5 (4) ◽  
pp. 347-352 ◽  
Author(s):  
A. J. Barak ◽  
H. C. Beckenhauer ◽  
R. A. Myers ◽  
R. N. Wilger
Keyword(s):  
Oxygen Uptake ◽  
Rat Liver ◽  
Liver Perfusion ◽  
Rat Liver Perfusion

Consequences of head injury and static cold storage on hepatic function: ex vivo experiments using a model of isolated perfused rat liver

Metabolism ◽  
2009 ◽  
Vol 58 (11) ◽  
pp. 1550-1556 ◽  
Author(s):  
Eric Levesque ◽  
Christophe Moinard ◽  
Valérie Besson ◽  
Nathalie Neveux ◽  
Jean-Claude Chaumeil ◽  
...  
Keyword(s):  
Head Injury ◽  
Rat Liver ◽  
Cold Storage ◽  
Ex Vivo ◽  
Hepatic Function ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver
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